In:
Science, American Association for the Advancement of Science (AAAS), Vol. 330, No. 6004 ( 2010-10-29), p. 665-669
Abstract:
Lymphoid tissue–inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt + innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt + precursors. The fate of RORγt + ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt + T cells, however, RORγt + ILCs develop in the absence of microbiota. Our study indicates that RORγt + ILCs evolve to preempt intestinal colonization by microbial symbionts.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1194597
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2010
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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