In:
Journal of International Medical Research, SAGE Publications, Vol. 13, No. 2 ( 1985-03), p. 96-101
Abstract:
We studied the effects of a non-narcotic, centrally acting antitussive, fominoben (PB89), on hypoxia in sixty patients suffering from chronic obstructive lung diseases (COLD), utilizing a double blind method and using the antitussive dextromethorphan as a reference drug. By the oral administration of a dose of 2 fominoben tablets (160 mg) three times a day for 2 weeks, a significant increase in arterial O 2 pressure (PaO 2 ), a decrease in arterial CO 2 pressure (PaCO 2 ), and a rise in pH were observed. However, alveolar-arterial O 2 difference (A-aDO 2 ) was not improved. On the other hand, after administration of a dose of 2 dextromethorphan tablets (30 mg) three times a day for 2 weeks, no increase in PaO 2 , no decrease in PaCO 2 and no improvement in A-aDO 2 were observed, although a rise in pH was seen. The increase in PaO 2 by fominoben was marked in COLD with dyspnoea. No improvement of A-aDO 2 despite a decrease in PaCO 2 suggests that fominoben might increase alveolar ventilation, in spite of its effect as an antitussive, exerting a favourable effect on hypoxia. It is, therefore, speculated that the cough centre and the respiratory centre are capable of functioning independently of each other.
Type of Medium:
Online Resource
ISSN:
0300-0605
,
1473-2300
DOI:
10.1177/030006058501300204
Language:
English
Publisher:
SAGE Publications
Publication Date:
1985
detail.hit.zdb_id:
2082422-1
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