In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1074, No. 1 ( 2006-08), p. 497-504
Abstract:
Abstract: An individual's drug abuse pattern is determined by a multitude of factors. Among these, simple pharmacological determinants of within‐binge drug consumption are sorely underinvestigated. We therefore determined if within‐session operant responsing to the ultra‐short‐acting mu opioid agonist remifentanil (RMF) was determined by blood or brain RMF levels or changes thereof. Our peri‐response analysis did not detect any “threshold” RMF level, either in blood or in the nucleus accumbens (NAc) core as a deep brain region that might determine a rat's “decision” to re‐emit a response during a multiple‐injection drug self‐administration session. The peri‐response analysis also failed to find any peak RMF level, either in blood or in the NAc core, which could serve as a “ceiling” level. Thus, our findings strongly suggest that titration of blood or brain RMF levels does not determine a rat's intra‐session operant response.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1369.050
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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