In:
British Journal of Pharmacy, University of Huddersfield Press, Vol. 7, No. 2 ( 2022-11-1)
Abstract:
Surfactants are often used to improve the solubility of a compound for dissolution studies in aqueous media. Having observed non-linear solubility enhancement with increasing surfactant concentration, this study investigated the effect of a poorly soluble, zwitterionic, moderately lipophilic drug, Compound A, on the critical micelle concentration (CMC)of sodium lauryl sulfate (SLS) in phosphate buffer. A force tensiometer was used to measure the surface tension of the solutions over a range of surfactant concentrations. The presence of Compound A demonstrated a decrease in the CMC, suggesting that the solution favours micellisation at lower surfactant concentrations in the presence of the drug. Future studies will use a fully saturated solution of Compound A to explore this observation further. Additional experiments will also investigate micelle formation of SLS with other compounds.
Type of Medium:
Online Resource
ISSN:
2058-8356
DOI:
10.5920/bjpharm.issue.99
DOI:
10.5920/bjpharm.1081
Language:
Unknown
Publisher:
University of Huddersfield Press
Publication Date:
2022
detail.hit.zdb_id:
2876071-2
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