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  • 1
    Online Resource
    Online Resource
    Paresthesia-Free Spinal Nerve Root Stimulation for the Treatment of Chronic Neuropathic Pain
    Elsevier BV ; 2020
    In:  Neuromodulation: Technology at the Neural Interface Vol. 23, No. 6 ( 2020-08), p. 831-837
    Details
    In: Neuromodulation: Technology at the Neural Interface, Elsevier BV, Vol. 23, No. 6 ( 2020-08), p. 831-837
    Type of Medium: Online Resource
    ISSN: 1094-7159
    URL: Article
    DOI: 10.1111/ner.13236
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2008283-6
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  • 2
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    Novel connectivity map normalization procedure for improved quantitative investigation of structural thalamic connectivity in temporal lobe epilepsy patients
    Wiley ; 2018
    In:  Journal of Magnetic Resonance Imaging Vol. 48, No. 6 ( 2018-12), p. 1529-1539
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 48, No. 6 ( 2018-12), p. 1529-1539
    Abstract: Connectivity studies targeting the thalamus have revealed patterns of atrophy and deafferentiation in temporal lobe epilepsy (TLE). The thalamus can be parcellated using probabilistic tractography to demonstrate regions of cortical connectivity; however, sensitivity to smaller or less connected regions is low. Purpose/Hypothesis To investigate thalamic structural connectivity in a wider range of cortical and limbic structures in TLE patients using a novel connectivity map normalization procedure. Study Type Retrospective. Population/Subjects Patients ( N  = 23) with medication‐resistant TLE and 34 healthy age‐matched controls. Field Strength/Sequence For T 1 and diffusion weighting a spoiled gradient sequence was used (41 gradient directions [b = 1000]). For T 2 mapping balanced steady‐state free precession was used. Images were acquired at 3T. Assessment Probabilistic tractography and a novel normalization procedure allowed comparison of groups with respect to thalamic connected volume, quantitative MRI, and diffusion tensor imaging (DTI) metrics. Statistical Tests Independent samples t ‐test, Cohen's d , and Mann–Whitney tests. Results Following normalization, significant differences in thalamic connected volumes were found in left TLE vs. controls bilaterally within the posterior parahippocampal gyrus (L: P  = 0.007, confidence interval [CI]: [173.306,1044.41] , effect size [ES] = 1.072; R: P  = 0.017, CI: [98.677,947.653], ES = 0.945), and contralaterally in the anterior temporal neocortex ( P  = 0.01, CI: (–2348.09, –333.719), ES = −1.021). This procedure revealed differences in thalamic connected volumes, where previously published procedures could not, and provided a basis for exploratory analysis of quantitative MRI and DTI metrics. Data Conclusion The novel connectivity map normalization scheme proposed here successfully allowed comparison between a wider range of cortical and limbic structures. Multiple volumetric and quantitative MRI and DTI‐related differences between TLE patients and controls were revealed following normalization. With validation from a larger cohort, thalamo‐temporal connection aberrancies may become useful biomarkers of disease states and probabilistic tractography as a procedure for identification of thalamic targets in modulatory therapies for TLE. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1529–1539
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v48.6
    DOI: 10.1002/jmri.26013
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1497154-9
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  • 3
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    Online Resource
    Investigation of hippocampal substructures in focal temporal lobe epilepsy with and without hippocampal sclerosis at 7T
    Wiley ; 2017
    In:  Journal of Magnetic Resonance Imaging Vol. 45, No. 5 ( 2017-05), p. 1359-1370
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 45, No. 5 ( 2017-05), p. 1359-1370
    Abstract: To provide a more detailed investigation of hippocampal subfields using 7T magnetic resonance imaging (MRI) for the identification of hippocampal sclerosis in temporal lobe epilepsy (TLE). Materials and Methods Patients ( n  = 13) with drug‐resistant TLE previously identified by conventional imaging as having hippocampal sclerosis (HS) or not (nine without HS, four HS) and 20 age‐matched healthy controls were scanned and compared using a 7T MRI protocol. Using a manual segmentation scheme to delineate hippocampal subfields, subfield‐specific volume changes and apparent transverse relaxation rate ( ) were studied between the two groups. In addition, qualitative assessment at 7T and clinical outcomes were correlated with measured subfield changes. Results Volumetry of the hippocampus at 7T in HS patients revealed significant ipsilateral subfield atrophy in CA1 ( P  = 0.001) and CA4+DG ( P 〈 0.001). Volumetry also uncovered subfield atrophy in 33% of patients without HS, which had not been detected using conventional imaging. was significantly lower in the CA4+DG subfields ( P  = 0.001) and the whole hippocampus ( P  = 0.029) of HS patients compared to controls but not significantly lower than the group without HS ( P  = 0.077, P  = 0.109). No correlation was found between quantitative volumetry and qualitative assessment as well as surgical outcomes (Sub, P  = 0.495, P  = 0.567, P  = 0.528; CA1, P  = 0.104 ± 0.171, P  = 0.273, P  = 0.554; CA2+CA3, P  = 0.517, P  = 0.952, P  = 0.130 ± 0.256; CA4+DG, P  = 0.052 ± 0.173, P  = 0.212, P  = 0.124 ± 0.204; WholeHipp, P  = 0.187, P  = 0.132 ± 0.197, P  = 0.628). Conclusion These preliminary findings indicate that hippocampal subfield volumetry assessed at 7T is capable of identifying characteristic patterns of hippocampal atrophy in HS patients; however, difficulty remains in using imaging to identify hippocampal pathologies in cases without HS. Level of Evidence : 2 J. MAGN. RESON. IMAGING 2017;45:1359–1370
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v45.5
    DOI: 10.1002/jmri.25447
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1497154-9
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  • 4
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    Online Resource
    Dorsal Root Entry Zone Lesioning for Brachial Plexus Avulsion Injuries: Case Series and Literature Review
    Frontiers Media SA ; 2021
    In:  Frontiers in Pain Research Vol. 2 ( 2021-11-17)
    Details
    In: Frontiers in Pain Research, Frontiers Media SA, Vol. 2 ( 2021-11-17)
    Abstract: Introduction: Brachial plexus avulsion (BPA) injuries commonly occur secondary to motor vehicle collisions, usually in the young adult population. These injuries are associated with significant morbidity, and up to 90% of patients suffer from deafferentation pain. Neuromodulation procedures can be efficacious in the treatment of refractory neuropathic pain, although the treatment of pain due to BPA can be challenging. Dorsal root entry zone (DREZ) lesioning is a classical and effective neurosurgical technique which has become underutilized in treating refractory root avulsion pain. Methods: A systematic review of the different technical nuances, procedural efficacy, and complication profiles regarding DREZ lesioning for BPA injuries in the literature is included. We also present an institutional case series of 7 patients with BPA injuries who underwent DREZ lesioning. Results: In the literature, 692 patients were identified to have undergone DREZ lesioning for pain related to BPA. In 567 patients, the surgery was successful in reducing pain intensity by over 50% in comparison to baseline (81.9%). Complications included transient motor deficits (11%) and transient sensory deficits (11%). Other complications including permanent disability, cardiovascular complications, infections, or death were rare ( & lt;1.9%). In our case series, all but one patient achieved & gt;50% reduction in pain intensity, with the mean pre-operative pain of 7.9 ± 0.63 (visual analog scale) reduced to 2.1 ± 0.99 at last follow-up ( p & lt; 0.01). Conclusion: Both the literature and the current case series demonstrate excellent pain severity reduction following DREZ ablation for deafferentation pain secondary to BPA.
    Type of Medium: Online Resource
    ISSN: 2673-561X
    URL: Article
    DOI: 10.3389/fpain.2021.749801
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 3035397-X
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  • 5
    Online Resource
    Online Resource
    Spinal Nerve Root Stimulation for Chronic Pain: A Systematic Review
    Elsevier BV ; 2023
    In:  Neuromodulation: Technology at the Neural Interface ( 2023-8)
    Details
    In: Neuromodulation: Technology at the Neural Interface, Elsevier BV, ( 2023-8)
    Type of Medium: Online Resource
    ISSN: 1094-7159
    URL: Article
    DOI: 10.1016/j.neurom.2023.07.008
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2008283-6
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  • 6
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    Online Resource
    Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5
    Springer Science and Business Media LLC ; 2015
    In:  Nature Communications Vol. 6, No. 1 ( 2015-09-03)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2015-09-03)
    Abstract: Synaptic plasticity is mediated by the dynamic localization of proteins to and from synapses. This is controlled, in part, through activity-induced palmitoylation of synaptic proteins. Here we report that the ability of the palmitoyl-acyl transferase, DHHC5, to palmitoylate substrates in an activity-dependent manner is dependent on changes in its subcellular localization. Under basal conditions, DHHC5 is bound to PSD-95 and Fyn kinase, and is stabilized at the synaptic membrane through Fyn-mediated phosphorylation of a tyrosine residue within the endocytic motif of DHHC5. In contrast, DHHC5’s substrate, δ-catenin, is highly localized to dendritic shafts, resulting in the segregation of the enzyme/substrate pair. Neuronal activity disrupts DHHC5/PSD-95/Fyn kinase complexes, enhancing DHHC5 endocytosis, its translocation to dendritic shafts and its association with δ-catenin. Following DHHC5-mediated palmitoylation of δ-catenin, DHHC5 and δ-catenin are trafficked together back into spines where δ-catenin increases cadherin stabilization and recruitment of AMPA receptors to the synaptic membrane.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/ncomms9200
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2553671-0
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  • 7
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    Online Resource
    Deep Brain Stimulation of the Globus Pallidus Internus and Externus in Multiple System Atrophy
    Wiley ; 2023
    In:  Movement Disorders
    Details
    In: Movement Disorders, Wiley
    Abstract: Multiple system atrophy with parkinsonism (MSA‐P) is a progressive condition with no effective treatment. Objective The aim of this study was to describe the safety and efficacy of deep brain stimulation (DBS) of globus pallidus pars interna and externa in a cohort of patients with MSA‐P. Methods Six patients were included. Changes in Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III (MDS‐UPDRS III), Parkinson's Disease Questionnaire (PDQ‐39) scores, and levodopa equivalent daily dose were compared before and after DBS. Electrode localization and volume tissue activation were calculated. Results DBS surgery did not result in any major adverse events or intraoperative complications. Overall, no differences in MDS‐UPDRS III scores were demonstrated (55.2 ± 17.6 preoperatively compared with 67.3 ± 19.2 at 1 year after surgery), although transient improvement in mobility and dyskinesia was reported in some subjects. Conclusions Globus pallidus pars interna and externa DBS for patients with MSA‐P did not result in major complications, although it did not provide significant clinical benefit as measured by MDS‐UPDRS III. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Article
    DOI: 10.1002/mds.29573
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041249-6
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