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  • 1
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 10 ( 2023-3-6)
    Materialart: Online-Ressource
    ISSN: 2297-1769
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2023
    ZDB Id: 2834243-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-12-12)
    Kurzfassung: Canine epileptic seizures are common neurological symptom presenting to veterinary practice. Idiopathic epilepsy (IE) with a suspected genetic background has been reported in several dog breeds. Although it has been reported in the Irish Setter (IS), the phenotypic characteristics have not yet been described. The aim of this study was to characterize the phenotype of IE in this breed and to trace its mode of inheritance. Owners of IS were requested to fill in a questionnaire via the Dutch Irish Setter Club concerning the epileptic seizures in their dogs. The data was assessed retrospectively using descriptive statistics. Forty-eight privately owned IS dogs fulfilling tier I criteria for IE according to the International Veterinary Epilepsy Task Force of both sexes were included in the study. The mean age of seizure onset was 41 months. Five of the dogs included in the study had an onset of seizures & gt;6 years of age. These dogs were classified with epilepsy of unknown cause (EUC). Primary generalized tonic-clonic seizures were the most common type of seizure and were seen in almost all dogs. Cluster seizures were reported in 54% of the studied population. Most owners reported pre- (56%) and post-ictal (97%) signs in their dogs. A pedigree analysis of one subpopulation was performed and traced the lineage of 13 affected IS. A segregation analysis of this population rejected a simple autosomal recessive inheritance pattern. The present study supports the occurrence of IE and EUC in the IS. The results provide clinical insight into epileptic seizures in this breed and may be a starting point for further, including genetic, analysis.
    Materialart: Online-Ressource
    ISSN: 2297-1769
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2834243-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Frontiers Media SA ; 2023
    In:  Frontiers in Veterinary Science Vol. 9 ( 2023-1-11)
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2023-1-11)
    Kurzfassung: Epilepsy in dogs is a common chronic and serious disorder and may have an impact on the quality of life of the owners as well as the dogs themselves. The aim of this pilot study was to investigate the QoL score of dogs suffering from idiopathic epilepsy and their owners and if possible, investigate whether a breed specific difference exists. Owners, either Dutch or Belgium, were asked to participate in a web based SurveyMonkey questionnaire. A total of 402 questionnaires representing 402 dogs with epilepsy were suitable for further analysis. Of the 402 dogs, 253 were males and 149 were females. Ninety-nine different breeds were represented. Fourteen breeds (177 dogs in total) were used to calculate breed specific scores; Australian Shepherd ( n = 8), Beagle ( n = 7), Belgian Tervuren dog ( n = 9), Belgian Groenendaeler dog ( n = 8), Border Collie ( n = 38), Chihuahua ( n = 9), Dachshund ( n = 13), Drentsche Patrijshond (a Dutch partridge dog) ( n = 14), French Bulldog ( n = 12), Golden Retriever ( n = 17), Labrador Retriever ( n = 18), and Rottweiler ( n = 12). For the Border Collie, there was a statistically significant correlation between “epilepsy related death,” the severity of the seizures ( p & lt; 0.001) and cluster seizures ( p & lt; 0.001). The quality of life of the Border Collie was scored lower compared to all other dogs ( p = 0.02). There were three breeds that had a minimal decrease in the overall quality of life score compared to all other dogs: the Chihuahua ( p = 0.03), Dachshund ( p = 0.001), and Golden retriever ( p = 0.01). The score for “caring for my epileptic dog decreases my own QoL” was high for the Border Collie, Boxer, French Bulldog, and Rottweiler, but was only found to be statistically significantly higher in the Border Collie ( p = 0.01). Scores for the Golden Retriever ( p = 0.04) and Labrador ( p = 0.006) were lower. In conclusion, this study reports breed specific quality of life scores of dogs with epilepsy and their owners, and underlines that breed by itself, is also an important factor when managing epilepsy in dogs.
    Materialart: Online-Ressource
    ISSN: 2297-1769
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2023
    ZDB Id: 2834243-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Frontiers Media SA ; 2023
    In:  Frontiers in Veterinary Science Vol. 10 ( 2023-8-14)
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 10 ( 2023-8-14)
    Kurzfassung: A 3.5-year-old male intact Staffordshire terrier crossbreed dog was presented with a one-week history of progressive paraparesis with fecal and urinary incontinence. Neurological examination was consistent with a T3-L3 myelopathy. A magnetic resonance imaging study revealed the presence of a well-circumscribed hemorrhagic space-occupying lesion at the level of T12, suspected to be a vascular malformation, such as cavernoma or arteriovenous fistula, primary hematoma or hamartoma; less likely considerations included hemorrhagic inflammation or hemorrhagic primary or secondary neoplasia. A dorsal laminectomy, durotomy, and midline dorsal myelotomy were performed with a surgical microscope, and the vascular lesion was identified and removed. Histological examination of surgical samples yielded fibrin, hemorrhage, hematoidin pigment, and some neural tissue. Although a lining wall was visualized during surgery consistent with a vascular malformation, there was no histological confirmation of such a structure, hampering definitive classification of the lesion. There was no gross or histopathological evidence that would support a diagnosis of a hamartoma or benign neoplasia. The dog was paraplegic with intact nociception the day following surgery. Ambulation was recovered within 2 weeks. Progressive and complete recovery of neurological function was seen over the next 12 weeks. No recurrence of neurological dysfunction was seen over a 12-month follow-up period. Surgical treatment should be considered in dogs with spinal intramedullary vascular lesions which can have a successful long-term outcome.
    Materialart: Online-Ressource
    ISSN: 2297-1769
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2023
    ZDB Id: 2834243-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-5-12)
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-5-12)
    Kurzfassung: The prevalence of idiopathic epilepsy (IE) within the Border Collie (BC) dog breed is high. The aim of this retrospective study was to describe the phenotype of BCs with IE and assess correlations between phenotypic variables and owner-provided quality-of-life (QoL) scores. Data of BCs diagnosed with IE during the period of five consecutive years were retrospectively analyzed. All the dogs were presented at least once to a veterinary neurology specialist at one of three veterinary referral hospitals and most were under the continued medical care of that specialist. Owners were requested to complete a standardized online questionnaire including quality-of-life (QoL) scoring questions. Data of a total of 116 BC dogs were included for analysis. The median age at onset of the first epileptic seizure (ES) was 33.5 months (6–188). A total of 34/86 (40%) of medically treated dogs received 1 antiseizure medication (ASM) and 52/86 (60%) received ≥2 ASMs. Phenobarbital was the most commonly employed ASM, used in 70/86 of treated dogs (81%). Four or more side effects were observed in 20/86 (23%) of treated dogs. Age at onset of first ES was significantly lower for dogs having experienced cluster seizures (CSs), status epilepticus (SE), or both (median 27 months) vs. dogs that had not experienced CS or SE (median 43 months). The QoL of BC with IE was scored with a median score of 7 out of 10. Owners scored their dog's QoL to have declined by a median of 30% during the course of life with IE with 39% (37/95) of owners scoring their dog's QoL to have declined by ≥50%. This study confirms the association of age at onset of first ES with the severity of epilepsy (e.g., presence of CS and/or SE) and further characterizes the phenotype of IE in BC dogs. QoL of BC can be heavily impacted by IE.
    Materialart: Online-Ressource
    ISSN: 2297-1769
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2834243-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Wiley ; 2022
    In:  Journal of Veterinary Internal Medicine Vol. 36, No. 6 ( 2022-11), p. 1872-1881
    In: Journal of Veterinary Internal Medicine, Wiley, Vol. 36, No. 6 ( 2022-11), p. 1872-1881
    Kurzfassung: Dystonia is a clinical sign and main feature of many movement disorders in humans as well as veterinary species. It is characterized by sustained or intermittent involuntary muscle contractions causing abnormal (often repetitive) movements, postures, or both. This review discusses the terminology and definition of dystonia, its phenomenology, and its pathophysiology, and provides considerations regarding the diagnosis and treatment of dystonia in dogs and cats. In addition, currently recognized or reported disorders in dogs and cats in which dystonia is a particular or main feature are discussed and comparisons are made between disorders featuring dystonia in humans and animals. We suggest that when describing the phenomenology of dogs and cats with dystonia, if possible the following should be included: activity being performed at onset (e.g., resting or running or exercise‐induced), body distribution, duration, responsiveness (subjective), severity, temporal pattern (i.e., paroxysmal or persistent, severity at onset and at later stages), presence or absence of autonomic signs (e.g., salivation), presence or absence of preceding signs (e.g., restlessness), presence or absence of signs after dystonia subsides (e.g., sleepiness), coexistence of other movement disorders, any other neurological manifestations, and possible links to administered medications, intoxications or other associated factors. We also suggest that dystonia be classified based on its etiology as either structural genetic, suspected genetic, reactive, or unknown.
    Materialart: Online-Ressource
    ISSN: 0891-6640 , 1939-1676
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2177690-8
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Wiley ; 2022
    In:  Journal of Small Animal Practice Vol. 63, No. 6 ( 2022-06), p. 493-493
    In: Journal of Small Animal Practice, Wiley, Vol. 63, No. 6 ( 2022-06), p. 493-493
    Materialart: Online-Ressource
    ISSN: 0022-4510 , 1748-5827
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2113384-0
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: Veterinary Radiology & Ultrasound, Wiley, Vol. 63, No. 3 ( 2022-05), p. 281-291
    Kurzfassung: The authors have observed a vertebral anomaly in French and English Bulldogs and termed this anomaly “vertebral vascular canal dysplasia (VVCD).” No previously published descriptions of this anomaly were found. The aims of this retrospective, multi‐institutional, observational study were to (1) describe the clinical, CT, and MRI characteristics of VVCD, and (2) estimate the prevalence and describe the characteristics of VVCD in a group of French and English Bulldogs. For descriptions of the anomaly, medical records and imaging studies of nine clinical cases with VVCD from several countries were reviewed. For estimation of prevalence, imaging studies of French and English Bulldogs from the United Kingdom (UK) and Italy were reviewed. All clinical case dogs had ≥5 thoracic vertebrae with VVCD affecting  〉 50% of vertebral body height (VBH). The prevalence of VVCD involving ≥1 thoracic vertebra in the UK population (CT identified) of English Bulldogs and French Bulldogs was, respectively, 83.3% (30/36) and 68.3% (28/41). English Bulldogs had significantly more thoracic vertebrae with VVCD than French Bulldogs ( P  =  〈  0.01). The prevalence of VVCD in ≥1 thoracic vertebra in the Italian population (MRI identified) of English Bulldogs and French Bulldogs was, respectively, 21.7% (5/23) and 6.6% (7/106). Vertebral vascular canal dysplasia was observed in normal as well as in malformed vertebrae (e.g., hemivertebrae). Findings from the current study introduced descriptions of VVCD that can be used as background for future studies.
    Materialart: Online-Ressource
    ISSN: 1058-8183 , 1740-8261
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2142058-0
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    In: Veterinary Record Case Reports, Wiley
    Kurzfassung: A 1‐year‐old, female, domestic shorthair cat was referred for orthopaedic evaluation of acute‐onset, non‐progressive left pelvic limb lameness of 2.5‐week duration. Orthopaedic examination revealed an abnormal gait with impaired ability to support weight on the left pelvic limb. There was marked atrophy of the quadriceps muscles. Neurological examination revealed an absent patellar reflex and decreased sensation in the cutaneous zone of the saphenous nerve of the left pelvic limb. Magnetic resonance imaging showed T2‐weighted/short‐tau inversion recovery hyperintensity and contrast enhancement in the area of the femoral nerve and within muscles innervated by this nerve. Findings were deemed consistent with traumatic nerve injury and denervation/traumatic myopathy or myositis/neuritis. Electromyography of the quadriceps muscles revealed fibrillation potentials and positive sharp waves. Follow‐up over the next 9 months revealed no changes in the neurological deficits. This was deemed to be consistent with either partial axonotmesis or partial neurotmesis of the left femoral nerve.
    Materialart: Online-Ressource
    ISSN: 2052-6121 , 2052-6121
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2733998-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Wiley ; 2021
    In:  Veterinary Record Case Reports Vol. 9, No. 3 ( 2021-09)
    In: Veterinary Record Case Reports, Wiley, Vol. 9, No. 3 ( 2021-09)
    Kurzfassung: A 4.5‐year‐old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of multifocal or diffuse intracranial lesions. MRI of the head revealed bilaterally symmetrical T2‐weighted hyperintensities in the pons and thalamus, suggestive of a metabolic or toxic aetiology. The pontine lesion on MRI resembled what in humans is known as the ‘trident sign’ reported in cases of pontine myelinolysis. Ancillary cerebrospinal fluid analysis revealed albuminocytologic dissociation and suspected myelin debris. No specific cause was identified, but the cat recovered over the next few weeks with only supportive therapy.
    Materialart: Online-Ressource
    ISSN: 2052-6121 , 2052-6121
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2733998-1
    Standort Signatur Einschränkungen Verfügbarkeit
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