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  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2018
    In:  International Journal of Fracture Vol. 211, No. 1-2 ( 2018-5), p. 203-216
    In: International Journal of Fracture, Springer Science and Business Media LLC, Vol. 211, No. 1-2 ( 2018-5), p. 203-216
    Type of Medium: Online Resource
    ISSN: 0376-9429 , 1573-2673
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1478986-3
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  • 2
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2021
    In:  IEEE Transactions on Medical Imaging Vol. 40, No. 1 ( 2021-1), p. 346-356
    In: IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers (IEEE), Vol. 40, No. 1 ( 2021-1), p. 346-356
    Type of Medium: Online Resource
    ISSN: 0278-0062 , 1558-254X
    RVK:
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2021
    detail.hit.zdb_id: 2068206-2
    detail.hit.zdb_id: 622531-7
    SSG: 12
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  • 3
    In: Frontiers in Urology, Frontiers Media SA, Vol. 3 ( 2023-3-14)
    Abstract: All clinical shock wave lithotripters produce an axisymmetric acoustic field without accounting for the anatomic features of the kidney or respiratory motion of the patient. This work presents a steerable and adjustable focusing electrohydraulic (SAFE) shock wave generator design with variable beam size and shape. Materials and methods 90 electrohydraulic transducers are mounted concentrically on a spherical basin with adjustable connection to individual transducers. Each transducer consists of 45 3D-printed titanium microelectrodes embedded in epoxy with a tip diameter of 0.3 mm. All the transducers are arranged in 5 concentric rings and sub-divided into 6 sectors. Results By changing the connections of individual transducers, the focused pressure field produced by the transducer array can be either axisymmetric with a -6 dB focal width of 14.8 mm in diameter, or non-axisymmetric with a long axis of 22.7 mm and a short axis of 15.1 mm. The elongated beam produces a peak positive pressure of 33.7 ± 4.1 MPa and comminution efficiency of 42.2 ± 3.5%, compared to 36.2 ± 0.7 MPa and 28.6 ± 6.1% for axisymmetric beam after 150 pulses at 20 kV. Conclusions We have demonstrated that the SAFE shock wave generator can produce an elongated non-axisymmetric pressure field with higher stone comminution efficiency. The SAFE shock wave generator may provide a flexible and versatile design to achieve accurate, stable, and safe lithotripsy for kidney stone treatment.
    Type of Medium: Online Resource
    ISSN: 2673-9828
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 3123829-4
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  • 4
    Online Resource
    Online Resource
    Optica Publishing Group ; 2019
    In:  Optica Vol. 6, No. 2 ( 2019-02-20), p. 198-
    In: Optica, Optica Publishing Group, Vol. 6, No. 2 ( 2019-02-20), p. 198-
    Type of Medium: Online Resource
    ISSN: 2334-2536
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2019
    detail.hit.zdb_id: 2779175-0
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  • 5
    Online Resource
    Online Resource
    American Physical Society (APS) ; 2015
    In:  Physical Review Applied Vol. 3, No. 3 ( 2015-3-3)
    In: Physical Review Applied, American Physical Society (APS), Vol. 3, No. 3 ( 2015-3-3)
    Type of Medium: Online Resource
    ISSN: 2331-7019
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2015
    detail.hit.zdb_id: 2760310-6
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  • 6
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2011
    In:  The Journal of the Acoustical Society of America Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2587-2587
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2587-2587
    Abstract: The dynamics of tandem bubble interaction in a microfluidic channel (800 × 25 μm2, W × H) are investigated using high-speed photography with resultant fluid motion characterized by particle imaging velocimetry. Single or tandem bubble is produced reliably via laser absorption by micron-sized gold dots (6 μm in diameter with 40 μm in separation distance) coated on a glass surface of the microfluidic channel. Using two pulsed Nd:YAG lasers at λ = 1064 nm and about 10 μJ/pulse, the dynamics of tandem bubble interaction (individual maximum bubble diameter of 50 μm with a corresponding collapse time of 5.7 μs) are examined at different phase delays. In close proximity (γ = 0.8), the tandem bubble interacts strongly with each other leading to asymmetric deformation of the bubble walls and jet formation, as well as the production of two pairs of vortices in the surrounding fluid rotating in opposite directions. The direction and speed of the jet (up to 95 m/s), as well as the orientation and strength of the vortices can be varied by adjusting the phase delay.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2011
    detail.hit.zdb_id: 1461063-2
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  • 7
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2013
    In:  The Journal of the Acoustical Society of America Vol. 134, No. 5_Supplement ( 2013-11-01), p. 4183-4183
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 134, No. 5_Supplement ( 2013-11-01), p. 4183-4183
    Abstract: A challenge in clinical shock wave lithotripsy (SWL) is stone translation due to a patient’s respiratory motion, in a direction perpendicular to shockwave propagation, which may negatively affect stone comminution while increasing the risk of tissue injury. We have developed a method using external masks and a modified lens geometry to transform the axisymmetric pressure distribution in the focal plane of an electromagnetic lithotripter into a non-axisymmetric elliptical distribution. At equivalent acoustic pulse energy (46 mJ), the peak pressure was reduced from 44 MPa to 38 MPa while the −6 dB focal width was increased from 7.4 mm for the original to 11.7 mm (major axis) and 7.9 mm (minor axis) of the modified field. In vitro stone comminution was performed in a tube holder (d = 14 mm) using a translation pattern with 12 breaths per minute and 15 mm in excursion distance. Stone comminution after 1000 shocks are 71.2 ± 4.4% and 65.2 ±8.3% (p  & lt; 0.05) along the major- and minor-axis of the modified field, respectively, compared to 62.6 ± 7.2% for the original axisymmetric field. These results suggest that an elongated pressure field aligned along the direction of stone motion may enhance stone comminution in SWL. [Work supported by the NIH and the NSF GRFP.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2013
    detail.hit.zdb_id: 1461063-2
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  • 8
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2011
    In:  The Journal of the Acoustical Society of America Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2678-2678
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2678-2678
    Abstract: We will present a computational model of the focusing of an electromagnetically induced pressure pulse by an acoustic lens and subsequent shock wave formation. Linear elasticity equations for the lens are solved simultaneously with Euler hydrodynamic equations for water considered to be a compressible medium with a Tait equation of state. The adaptive mesh refinement model allows both three-dimensional and two-dimensional axisymmetric computations. A number of coupling approaches at the lens-water interface are investigated by comparison to experimental results: transfer only of pressure boundary condition, coupling of displacement velocities, and a buffer linear elasticity region in the water immediately adjacent to lens. The model is validated against single-medium measurements (water or lens material), and the complete experimental shock wave formation process. Initial results from a crack propagation model in stone simulants placed at the lithotripter focus will also be presented.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2011
    detail.hit.zdb_id: 1461063-2
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  • 9
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2008
    In:  The Journal of the Acoustical Society of America Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3561-3561
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3561-3561
    Abstract: Recent studies have highlighted the potential for using laser-induced micro-cavitation in lab-on-a-chip devices. Shear stress in a liquid can be controlled and significantly enhanced by bubble-bubble interaction, providing new options for in situ cell treatment. Two micro-bubbles (10 μs life time) are generated in a 25-μm liquid layer using 5 ns tandem laser pulses delivered through the objective of a microscope. Bubble-bubble interaction in nearly two-dimensional flow is observed using high-speed video cameras. Two liquid micro-jets moving in opposite directions can be generated when the second bubble is produced at the maximum size of the first one. The jet velocity is estimated about 35 m/s. Particle imaging velocimetry reveals vortex flow motion around the oscillating bubble lasting for about 200 μs. Cell lyses produced by jetting from asymmetric oscillation of tandem microbubbles are investigated at various bubble-cell distances and compared with the results from single symmetric bubble oscillation. The interaction of tandem microbubbles can produce microjetting, leading to damage of adjacent single biological cells.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2008
    detail.hit.zdb_id: 1461063-2
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  • 10
    Online Resource
    Online Resource
    Acoustical Society of America (ASA) ; 2012
    In:  The Journal of the Acoustical Society of America Vol. 131, No. 4_Supplement ( 2012-04-01), p. 3248-3248
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 131, No. 4_Supplement ( 2012-04-01), p. 3248-3248
    Abstract: Recent experiments, motivated by ultrasound-mediated drug and gene delivery, have utilized laser-generated tandem microbubbles to produce directional and targeted membrane poration of individual cells in microfluidic systems [Sankin et al., Phys. Rev. Lett. 105, 078101 (2010)]. Two models describing the dynamics of coupled bubbles between parallel plates have been applied to understand these observations. The first approach is based on the Boundary Element Method in both 2D and 3D coordinate systems for bubbles bounded by finite rigid plates. Deformation of the bubble surfaces is taken into account, capturing phenomena such as bubble jetting and fragmentation [Hsiao et al., Ultrasound Med. Biol. 36, 2065-2079 (2010)] . The second approach is semi-analytic, accounts for fluid compressibility and elasticity of the plates, but is limited to spherical bubble pulsation [Hay et al., J. Acoust. Soc. Am. 129, 2477(A) (2011)]. Observations of tandem bubble interaction with adjacent biological cells and their potential for controlling cell poration will be discussed. Comparisons between simulation results obtained from the two models, as well as comparisons between the models and experimental measurements, will be presented. [Work supported by NIH grant nos. DK070618 and EB011603 (UT), 2R44EB005139-02A1 (DFI), DK052985 and RR016802 (Duke).]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    RVK:
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2012
    detail.hit.zdb_id: 1461063-2
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