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  • 1
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: Due to their numerous advantages, people have recently been more interested in herbal medicines. Today, many people successfully treat a range of conditions with herbal medicines. Even if the majority of these operations are unique, more than 80% of the world's population relies on herbal medicines and products for a healthy living. The growing popularity of herbal products has also given rise to a variety of creative misdeeds and product manipulations that have enraged consumers and manufacturers and, in some cases, had disastrous results. The development of actual logical systems that can precisely define the phytochemical composition, including quantitative studies of marker/bioactive composites and other essential elements, is a serious challenge for scientists. To create a harmonious chemical profile, a harmonious natural effort, Standardization is a key step, whether it be done through a simple quality assurance programme for the product and production of herbal medicines. Here is a review 1) Although quality thickness is one of the basic characteristics of pharmaceuticals, natural drugs and their remedies must deal with this complex issue. It is delicate to simply use the commonly utilised assessment styles in chemical medications due to the complex chemical makeup and extensive pharmacological effect of natural medicines. Exploring novel evaluation methods that are appropriate for the properties of natural medications is therefore crucial. With the lightning-fast development of logical methods and the growing appreciation for the quality of natural sauces, increasing numbers of experimenters have put forth a number of novel concepts and advancements in technology. This review primarily focuses on the fundamental ideas, unique traits, and practical applications of chemical and natural evaluations, as well as how these elements combine to assess the quality and thickness of natural sauces
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: GRDDSs are an innovative tactic in this area (Gastro Retentive Drug Delivery System). GRDDSs can improve the regulated administration of drugs with an absorption window by continuously releasing the drug for a long period before it reaches its absorption site. The aim of this study was to investigate, compile, and succinctly summarise both recent and older literatures, with a focus on methods being applied right now to prolong gastric residency duration. They include of high density systems, floating systems, swelling and expanding systems, bio/mucoadhesive systems, and various delayed gastric emptying devices. The current study briefly discusses the categorization, formulation concerns for gastroretentive drug delivery systems, variables affecting stomach retention, advantages, limitations, and applications. To understand the many physiological hurdles involved in establishing stomach retention, we have highlighted important factors impacting it. Then, we assessed the various gastroretentive techniques that have been devised and developed up to this point, including high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, ultra porous hydrogel, and magnetic systems. Additionally, the advantages of gastroretentive medicine administration systems were thoroughly covered.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: Due to their numerous benefits, herbal medications are increasingly attracting people's attention. As treatment options for many disorders, herbal formulations have gained widespread acceptance. Over 80% of the world's population relies on herbal products and medications for a healthy lifestyle, despite the fact that the majority of these uses are unconventional. As the usage of herbal goods has increased, so have the misuse and adulteration of the products, which has disappointed customers and producers and, in some cases, had disastrous results. The creation of reliable analytical techniques that can profile the phytochemical composition with accuracy, including quantitative studies of marker/bioactive chemicals and other important elements, is a significant challenge for scientists. Standardization is a critical essential step in the development ofa quality assurance process, a consistent chemical profile, or simply a constant biological activity for the manufacture and manufacturing of herbal medications. The numerous convectional approaches and more recent advancements are covered in the current review article. Recent developments have been noted in the areas of DNA fingerprinting, metabolomics, differential pulse polarography, chemometrics, X-ray diffraction, etc. Contributions of chromatographic and capillary electrophoresis methods to the standardisation of herbal medicines are also described.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: The field of regulatory affairs (RA) serves as a link between the global pharmaceutical sector and regulators. It was created in response to governments’ desire to safeguard the public’s health by regulating the efficacy and safety of pharmaceuticals, veterinary drugs, medical equipment, pesticides, agricultural chemicals, cosmetics, and other goods. Companies that are in charge of the development, manufacture, testing, and sale of these products aim to guarantee that they deliver safe and efficient goods for the welfare of the general public. Different registration criteria for pharmaceutical products are covered by pharmaceutical drug regulatory affairs. As a result of the demand for superior quality medicine that includes safety and efficacy in the areas of not only pharmacy but also veterinary medicine, medical devices, insecticides, pesticides, agrochemicals, cosmetic, and supplementary medicine, a new profession called pharmacy was created. Additionally, it created a connection between the pharmaceutical corporation and the regulating bodies. Maintaining the appropriateness and accuracy of the product information is another duty assigned to it. And its primary responsibility is to serve as a point of contact for regulatory agencies, providing expertise and regulatory intelligence in translating regulatory requirements into realistic, workable plans, and advising the company on regulatory aspects and the regulatory environment that would affect their proposed projects..
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: As of late people groups are getting pulled in towards natural prescriptions because of many benefits. Naturals detail broad agreeableness as restorative specialists for a few infections. Albeit, the vast majority of these applications are unorthodox, it is anyway a well-established reality that more than 80% of the total populace relies upon natural drugs and item for solid living. This ascent in these of natural item has likewise led to different types of misuse and corruption of the items prompting customers' and makers' mistake and in a few cases deadly results. The advancement of valid scientific strategies that would dependably this phytochemical's characteristics, incorporating numeric investigations of template mixtures additionally significant a significant test scientist. Standardization is a significant stage for the foundation of a steady natural.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: Adverse Drug Reaction is the process that it involves the unaffected and undesirable effects of medication that used during normal clinical use. Adverse drug effects are normal some time but at some case there are some very serious adverse effects that can be very hazardous can be life threatening Adverse medication responses may make patients feel uneasy or untrusting of their doctors, leading them to look for other forms of self-care, which may lead to more adverse drug reactions (ADRs). In this review article it includes all introduction of the Adverse drug effects and mainly there is Focus on the biological hazard effects. Review article is based on the introduction of adverse effects of Drug some relevant definition and terms. The classification of ADR is done different types are enlisted in the review article. The all articles are about the ADR detection, identification and prevention. It also includes the relevant casualties assessment overview done by the WHO-UMC Monitoring Centre. In this the review of market greatest Risk factor are assessed by the monitoring center and further the methods for prevention of the ADR are suggested. If any ADR is reported, then all relevant information is collected by using questionnaire introduced in this review. My overall intention for choice of the reviewing the article is just to introduce the termpharmacovigilance and ADR in detailed and deep manner. the pharmacovigilance term is very important in market sector of view because it defines the performance of the product on human life.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 7
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric populations, the latter being particularly heterogeneous. These differences in pharmacokinetics and pharmacodynamics justify specific studies but raise a number of ethical and practical issues. The main practical difficulties to circumvent while performing clinical studies in children are the invasiveness of the procedures and the obstacles to patient recruitment. The invasiveness related to pain/anxiety and blood loss precludes the performance of classical pharmacokinetic studies in children in many instances, particularly in neonates and infants. Population approaches, which rely on pharmacokinetic-pharmacodynamic modelling, are particularly appealing in paediatric populations because these models can cope with sparse data. The relevance of population approaches to investigation of the dose-concentration-effect relationships and to qualitative/quantitative assessment of factors that may explain interindividual variability has already been emphasized.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 8
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: In order for clinical practise, public health efforts, and effective drug regulatory systems to function effectively, pharmacovigilance—the term used to describe the processes for recording and analysing adverse drug reactions—must be implemented. A high level of skill is required to grasp pharmacovigilance in order to swiftly identify pharmacological dangers and to defend the product against an unjustified withdrawal. The volume of data handled has increased as a result of the reporting of number of the adverse drug reactions (ADRs). The present global network of pharmacovigilance centres, which is supervised by the Uppsala Monitoring Center, would be strengthened by an independent review procedure. This would consider disputed and important pharmaceutical safety problems that might have a detrimental effect on public health across international borders. Recently, the main goal of pharmacovigilance has been to identify previously unrecognised or poorly understood adverse drug reactions. Clinical research must include pharmacovigilance, which is becoming more and more popular in many countries. To improve drug safety and monitoring, pharmacovigilance faces significant obstacles at the turn of the millennium. Currently, a number of pharmacovigilance centres are engaged in this global effort to monitor the safety of pharmaceuticals. We'll discuss medication safety, the role of worldwide pharmacovigilance centres, the benefits and downsides of pharmacovigilance, and how the healthcare sector can employ it in the future in this review. (4) Pharmacovigilance encourages the correct and safe use of drugs. Adverse drug responses (ADRs) must be reported spontaneously, and this is a crucial part of pharmacovigilance. ADRs are, nonetheless, considerably underreported. In developing nations, adverse medication responses are now a significant issue. Understanding pharmacovigilance could serve as the foundation for actions meant to increase reporting rates and lower ADRs. (1).
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: To evaluate a high-quality medicine, herbal compositions must be standardised. The total of all aspects that directly or indirectly influence the safety, efficacy, and acceptance of a drug product is the quality of a herbal drug. The field of herbal drugs and formulations is developing quickly nowadays, and there is still much to learn about the standardisation of these products. However, the lack of a standardised parameter hurts herbal treatment. The primary constraints are the absence of standards for raw materials, processing techniques, and finished goods, product formulas, and absence of quality control standards. To assure the quality, safety, and effectiveness of herbal medicine using contemporary methods, it is required to measure the regulation of herbal medicine.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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  • 10
    Online Resource
    Online Resource
    Naksh Solutions ; 2023
    In:  International Journal of Advanced Research in Science, Communication and Technology
    In: International Journal of Advanced Research in Science, Communication and Technology, Naksh Solutions
    Abstract: Transdermal drug delivery system is an essential part of novel drug distribution system. The topically administered medications in the form of patches which when applied to the skin deliver the drug .For operative TDDS the drug are easily able to penetrate the skin and easily reach the target site. TDDS avoids the first pass metabolism, less frequency of administration, reduction gastrointestinal side effects. Adverse effects are minimized due to steady and optimum blood concentration. It has greater bioavailability and efficacy of drug. The human skin is multi-layered organ composed of many histological layers. Skin is the largest organ in the body. Its major functions are protection of major or vital internal organs for the external influences, temperature regulations, control of water output and sensation. Polymer should be chemically non-reactive, should not decompose on storage, should be non-toxic, cost should not be high. E.g. - cellulose derivatives, zein, gelatin etc. Backing films play a vital role in the transdermal patch and the role of the film is to protect the active layer. Transdermal patches can be evaluated by interaction studies thickness, weight uniformity, drug content, in vitro study,moisture content, swelling index basic component of TDDS.
    Type of Medium: Online Resource
    ISSN: 2581-9429
    Language: English
    Publisher: Naksh Solutions
    Publication Date: 2023
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