GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Life Sciences, Elsevier BV, Vol. 320 ( 2023-05), p. 121351-
    Type of Medium: Online Resource
    ISSN: 0024-3205
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 3378-9
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    In: International Journal of Biological and Chemical Sciences, African Journals Online (AJOL), Vol. 17, No. 7 ( 2024-02-22), p. 2909-2924
    Abstract: Les populations du centre et du Septentrion du Bénin utilisent les feuilles, les calices et les graines de la variété blanche Hibiscus  sabdariffa L. dans l’alimentaire et en pharmacopée pour la prévenir et le traiter diverses maladies. Ce travail visait d’une part à  déterminer la composition en métabolites secondaires de ces trois organes sus-mentionnés et d’autre part, à évaluer la toxicité aiguë de  leurs extraits. A cet effet une analyse phytochimique basée sur des réactions de coloration et/ou de précipitation a été effectué afin  d’identifier quelques composés chimiques qu’ils contiennent. La toxicité aigüe des extraits des organes a été testée par observation  durant 14 jours après gavage par une dose unique de 5000 mg/kg pv à des rats Wistar contre des témoins. Les tests phytochimiques révèlent la présence des tanins galliques, des flavonoïdes, des anthocyanes, des leuco-anthocyanes, des mucilages, des composés  réducteurs, des anthracéniques combinés dans les trois organes. En ce qui concerne la toxicité, les extraits des trois organes de la plante  n’ont pas provoqué de variations significatives des taux d’urée, de l’uricémie des bilirubines, l’Aspartate Aminotransférase (ASAT),   l’Alanine Aminotransférase (ASAT) et la Phosphatase Alcaline (PAL) chez rats Wistar (p 〉 0,05).   English title: Phytochemical analysis of Hibiscus sabdariffa Linn (Malvaceae) ethanolic extracts and evaluation of acute oral toxicity in  Wistar rats The populations of central and northern Benin use the leaves, chalices and seeds of the white variety Hibiscus sabdariffa L. in food and in  pharmacopoeia in the prevention and treatment of various diseases. This work aimed on the one hand to determine the composition in  secondary metabolites of these three above-mentioned organs and on the other hand, to evaluate the acute toxicity of their extracts. To  this end, phytochemical analysis based on coloring and/or precipitation reactions was carried out in order to identify some chemical  compounds they contain. The acute toxicity of the organ extracts was tested by observation for 14 days after gavage with a single dose of  5000 mg/kg bw in Wistar rats against controls. Phytochemical tests reveal the presence of gallic tannins, flavonoids, anthocyanins,  leuco-anthocyanins, mucilages, reducing compounds, anthracenics combined in the three organs. With regard to toxicity, the extracts of  the three plant organs did not cause significant variations in the levels of urea, uricemia, bilirubins, Aspartate Aminotransferase (AST),  Alanine Aminotransferase (AST) and alkaline phosphatase (ALP) in Wistar rats (p 〉 0.05).
    Type of Medium: Online Resource
    ISSN: 1997-342X , 1991-8631
    Language: Unknown
    Publisher: African Journals Online (AJOL)
    Publication Date: 2024
    detail.hit.zdb_id: 2536788-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    In: Journal of Toxicology, Wiley, Vol. 2023 ( 2023-7-21), p. 1-10
    Abstract: Background. Pedalium murex (P. murex) is used in folk medicine for treatment of male infertility. However, scientific data on its safety are limited. Objective. This study was carried out to assess the acute and repeated dose 28-day oral toxicity of the aqueous extracts from P. murex leafy stem and fruit in Wistar rats. Methods. The acute toxicity test was performed according to the line 423 of the Organization for Economic Cooperation and Development (OECD) guidelines. The rats were randomly divided into three groups (n = 3). The control group received distilled water, while the experimental groups were given at a single dose, 5000 mg/kg of each extract. The repeated dose 28-day oral toxicity was performed according to the line 407 of the OECD guidelines. 35 rats divided into 7 groups of 5 male rats each were daily treated for 28 days with each extract at 200 mg/kg, 400 mg/kg, and 800 mg/kg, respectively. The in-life parameters were recorded during the follow-up. At the end of this study, organ weights, hematology, biochemistry, and histology parameters were analyzed. Results. In the acute oral toxicity test, there was no morbidity or mortality related to the treatments. Both extracts belong therefore to category 5 of the globally harmonized system (GHS) of classification. In the repeated dose 28-day oral toxicity test, both extracts did not alter animal’s behavior. However, both extract administration led to proteinuria and renal damages. Conclusion. P. murex leafy stem and fruit aqueous extracts exhibited potential nephrotoxicity. Therefore, care should be taken when they are used over an extended period.
    Type of Medium: Online Resource
    ISSN: 1687-8205 , 1687-8191
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2495098-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...