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  • 1
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    Marine inspired antiplasmodial thiazinoquinones: synthesis, computational studies and electrochemical assays
    Royal Society of Chemistry (RSC) ; 2015
    In:  RSC Advances Vol. 5, No. 86 ( 2015), p. 70689-70702
    Details
    In: RSC Advances, Royal Society of Chemistry (RSC), Vol. 5, No. 86 ( 2015), p. 70689-70702
    Type of Medium: Online Resource
    ISSN: 2046-2069
    URL: Article
    DOI: 10.1039/C5RA09302C
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2015
    detail.hit.zdb_id: 2623224-8
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  • 2
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    P4547Serum biochemical determinants of peripheral congestion assessed by bioimpedance vector analysis in acute heart failure
    Oxford University Press (OUP) ; 2019
    In:  European Heart Journal Vol. 40, No. Supplement_1 ( 2019-10-01)
    Details
    In: European Heart Journal, Oxford University Press (OUP), Vol. 40, No. Supplement_1 ( 2019-10-01)
    Abstract: The pathophysiology of peripheral congestion is poorly investigated in patients with acute heart failure (AHF). Purpose This study evaluated the relative contribution of serum colloid osmotic pressure (COP), relative plasma volume status (PVS), biomarkers of renal function, electrolytes, haemoglobin, and brain natriuretic peptide (BNP) in peripheral fluid overload using bioimpedance vector analysis (BIVA). Methods We retrospectively analysed data from 485 patients with AHF. Hydration status was evaluated by semiquantitative and quantitative approach using BIVA (R/Xc graph) and Hydration Index (HI), respectively. COP was calculated from albumin and total protein concentration, while relative PVS was calculated from validated equations. Results Congestion assessed by BIVA was observed in 304 (63%) patients and classified as mild (30%), moderate (42%), and severe (28%). On univariate analysis, HI was inversely correlated with COP (P 〈 0.01), glomerular filtration rate (P 〈 0.01), and haemoglobin (P 〈 0.01), while positive correlations were found for relative PVS (P 〈 0.05), BNP (P 〈 0.01), and blood urea nitrogen (BUN; P 〈 0.01). On stepwise multivariate analysis, COP explained 12% of the total variability, while BUN, PVS, haemoglobin, and BNP added a further 6%, 4%, 2%, and 1%, respectively, to the final explanatory model. Conclusions COP was the major determinant of the presence and entity of peripheral congestion assessed by BIVA. BUN, PVS, haemoglobin, and BNP revealed reduced influence on congestion as compared with COP. Routine laboratory testing could be useful in peripheral fluid accumulation. Future studies should evaluate the relationship between COP and pharmacological target therapies for the fluid management of AHF patients. Acknowledgement/Funding None
    Type of Medium: Online Resource
    ISSN: 0195-668X , 1522-9645
    URL: Article
    DOI: 10.1093/eurheartj/ehz745.0938
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2001908-7
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  • 3
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    P338 PERFORMANCE OF THE SIMPLIFIED HEART FAILURE HYDRA SCORE IN PREDICTING ONE–YEAR MORTALITY: COMPARISON WITH HYDRA SCORE
    Oxford University Press (OUP) ; 2023
    In:  European Heart Journal Supplements Vol. 25, No. Supplement_D ( 2023-05-18), p. D177-D177
    Details
    In: European Heart Journal Supplements, Oxford University Press (OUP), Vol. 25, No. Supplement_D ( 2023-05-18), p. D177-D177
    Abstract: We have recently proposed a new prediction model for risk mortality based on four parameters of congestion to predict mortality in patients with acute or chronic heart failure. This risk model (HYDRA Score, HS) is based on the number of parameters of congestion above significant cut–offs (range 0–4): BNP & gt;441 pg/mL, estimated plasma volume status (ePVS) & gt;5.3 dL/gr, bioimpedance vector analysis (BIVA) & gt;73.8%, and BUN/creatinine ratio (BUN/Cr) & gt;25. As bioimpedance vector analysis is a measure of peripheral congestion but it is not frequently used in clinical practice, we evaluated the performance of the risk model by including the presence of peripheral edema in place of BIVA (HYDRA Semplified Score, HSS). Methods and results We analysed data from 436 HF patients. During a one–year follow–up 81 patients died (18.6%). Discrimination for all–cause mortality was compared by Harrell‘s C–statistic. Calibration was assessed by Hosmer–Lemeshow test and global performance by Nagelkerke‘s R2. Correlation between scores was assessed by Spearman rank test. Correlation between the scores was good (rho = 0.91, p & lt;0.001). The two risk models showed similar results in terms of discrimination analyses (HS 0.786 vs HSS 0.760; p=0.09) and global performance (R2 = 0.26 and R2 =0.21). The Hosmer–Lemeshow goodness–of–fit test demonstrated the best calibration of HS risk model (χ2 6.5, P=0.60 for HS model and χ2 7.7, P=0.45 for HSS model). Conclusions Simplified HYDRA score seems a good and friendly model risk to predict one–year mortality in patients with heart failure and could be used as alternative to HYDRA score.
    Type of Medium: Online Resource
    ISSN: 1520-765X , 1554-2815
    URL: Article
    DOI: 10.1093/eurheartjsupp/suad111.411
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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  • 4
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    P225 RESPIRATORY FAILURE AND BIOELECTRICAL PHASE ANGLE ARE INDEPENDENT PREDICTORS FOR LONG–TERM SURVIVAL IN ACUTE HEART FAILURE
    Oxford University Press (OUP) ; 2022
    In:  European Heart Journal Supplements Vol. 24, No. Supplement_C ( 2022-05-18)
    Details
    In: European Heart Journal Supplements, Oxford University Press (OUP), Vol. 24, No. Supplement_C ( 2022-05-18)
    Abstract: The assessment of long term mortality in acute decompensated heart failure (ADHF) is challenging. Respiratory failure and congestion play a fundamental role in risk stratification of ADHF patients. The aim of this study was to investigate the impact of arterial blood gases (ABG) and congestion on long–term mortality in patients with ADHF. Methods and Results We enrolled 252 patients with ADHF. Brain natriuretic peptide (BNP), blood urea nitrogen (BUN), phase angle as assessed by means of bioimpedance vector analysis (BIVA), and ABG analysis were collected at admission. The endpoint was all–cause mortality. At a median follow–up of 447 days, (IQR: 248–667), 72 patients died 1–840 days (median 106, IQR: 29–233) after discharge. Respiratory failure types I and II was observed in 78 (19%) and 53 (20%) patients, respectively. The ROC analyses revealed that the cut–off points for predicting death were: & gt;441 pg/mL for BNP, & gt;30 mg/dL for BUN, ≤ 69.7 mmHg for partial pressure in Oxygen (PaO2), and ≤4.9° for Phase Angle. Taken together, these four variables proved to be good predictors for long–term mortality in ADHF (AUC 0.78, 95% CI 0.72–0.78), thus explaining 60% of all deaths. A multiparametric score based on these variables was determined: each single–unit increase promoted a 2.2–fold augmentation of the risk for death (HR 2.2, 95% CI 1.8–2.8, P  & lt; 0.0001). Conclusions A multiparametric approach based on measurements of BNP, BUN, PaO2, and phase angle is a reliable approach for long–term prediction of mortality risk in patients with ADHF.
    Type of Medium: Online Resource
    ISSN: 1520-765X , 1554-2815
    URL: Article
    DOI: 10.1093/eurheartj/suac012.217
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 5
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    P254 THE ROLE OF GENDER IN CONGESTION STATUS EVALUATION IN PATIENTS WITH ACUTE HEART FAILURE
    Oxford University Press (OUP) ; 2022
    In:  European Heart Journal Supplements Vol. 24, No. Supplement_C ( 2022-05-18)
    Details
    In: European Heart Journal Supplements, Oxford University Press (OUP), Vol. 24, No. Supplement_C ( 2022-05-18)
    Abstract: The evaluation of congestion play a central role in the management of patients with acute heart failure (AHF).The impact of gender on congestion in patients with HF is still a matter of debate. The objective of this analysis was to evaluate the impact of gender on congestion status at admission of patients hospitalized for AHF. Methods We consecutively enrolled 487 patients with AHF (50% female). We assessed peripheral edema, jugular venous distention ( & gt;10 cm), B–type natriuretic peptide (BNP), hydration status (by means of bioimpedance analysis), and estimated plasma volume (by means of the Duarte’s formula [D–ePVS] and Kaplan–Hakim formula [KH–ePVS] ). Results Home medications and body mass index were not different between women and men. Women were older (79 yrs vs 77 yrs, P = 0.005), showed better left ventricular ejection fraction (mean 50% vs 38%, P  & lt; 0.001), and increased plasma concentrations in blood urea nitrogen (40 mg/dL vs 25 mg/dL, P = 0.02) and serum creatinine (1.5 mg/dL vs 1.5 mg/dL, P = 0.8). At physical examination, the number of patients with peripheral edema and jugular venous distention was not significantly different between women and men (53% vs 45% and 60% vs 55%, respectively). BNP levels (median 1100 pg/mL vs 994 pg/mL) and hydration status (78% vs 79%) were similar in women and men, while ePVS was higher in women (D–ePVS 6.0 ± 1.6 dL/gr vs 5.1 ± 1.5 dL/gr, P  & lt; 0.001; KH–ePVS 7.9% ± 13% vs –7.3 ±12%, P  & lt; 0.001). Conclusions The evaluation of congestion in AHF using physical examination and multiparametric approaches was similar between women and gender. Women rather showed higher plasma volume as compared to male individuals.
    Type of Medium: Online Resource
    ISSN: 1520-765X , 1554-2815
    URL: Article
    DOI: 10.1093/eurheartj/suac012.246
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 6
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    C57 DUAL ANTIPLATELET THERAPY DID NOT PREDICT ALL–CAUSE BLEEDING AT LONG–TERM FOLLOW–UP AFTER ACS: A SUBANALYSIS FROM THE APULIA PONTE ACS STUDY
    Oxford University Press (OUP) ; 2022
    In:  European Heart Journal Supplements Vol. 24, No. Supplement_C ( 2022-05-18)
    Details
    In: European Heart Journal Supplements, Oxford University Press (OUP), Vol. 24, No. Supplement_C ( 2022-05-18)
    Abstract: Dual antiplatelet therapy (DAPT) has important implications for clinical outcomes in coronary disease. Nevertheless, the risk for bleeding often impact on the long–term administration of DAPT. The aim of this study was to evaluate the determinants of bleeding risk after ACS. Methods This was a subanalysis of the PONTE ACS study. The PONTE ACS study is a prospective, longitudinal, cohort study which enrolled patients who were discharged from HUB centres of ASL BARI after coronary revascularization and/or ACS. They underwent clinical evaluation at 30 days, 3, 6 and 1 year–follow–up. The data were collected after including the data in the electronic medical record of the PONTE ACS study. Anthropometric, clinical and pharmacological parameters, instrumental and laboratory examinations were included. Data were computed in order to evaluate the major determinants of all–cause bleeding at one–year follow–up. Results We finally enrolled 2476 patients (77.4% male, mean age: 67.2±12.0 years). Pharmacological treatments were optimized during the follow–up visits. According to anti–thrombotic therapies, 92.1% of patients persisted on DAPT at one–year follow–up. The number of patients on DAPT+anticoagulant were: 4.4%. All–cause bleeding occurred in 2.2% of patients. Anthropometric characteristics (height [β: –0.04594 ± 0.01610, p = 0.0044] and weight [β: –0.03043 ± 0.01035, p = 0.033] ), male gender [β: –0.7008 ± 0.2818, p = 0.0129], and age [β: 0.02535 ± 0.01219, p = 0.0376] were the major determinants of all–cause bleeding at univariate regression analysis but they were not confirmed at multivariate regression analysis (p=ns). Kaplan Meier curve points out the impact of age on all–cause bleeding (Figure 1). Nor DAPT or triple therapy remained associated with all–cause bleeding at one year follow–up. Conclusions Long–term DAPT is not a predictor of all–cause bleeding in patients who suffered ACS and/or coronary revascularization.
    Type of Medium: Online Resource
    ISSN: 1520-765X , 1554-2815
    URL: Article
    DOI: 10.1093/eurheartj/suac011.056
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 7
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    P27 DOPPLER ULTRASOUND SELECTION AND FOLLOW–UP OF THE INTERNAL MAMMARY ARTERY AS CORONARY GRAFT
    Oxford University Press (OUP) ; 2023
    In:  European Heart Journal Supplements Vol. 25, No. Supplement_D ( 2023-05-18), p. D49-D49
    Details
    In: European Heart Journal Supplements, Oxford University Press (OUP), Vol. 25, No. Supplement_D ( 2023-05-18), p. D49-D49
    Abstract: The impact of coronary artery disease (CAD) on all–cause mortality and overall disabilities is well–established. Percutaneous and/or surgical coronary revascularization procedures dramatically reduced the occurrence of adverse cardiovascular events in patients suffering with atherosclerosis. Specifically, guidelines from the European Society of Cardiology on the management of myocardial revascularization promoted coronary artery by–pass graft (CABG) intervention in patients with specific alterations in coronary tree due to higher beneficial effects of this procedure as compared to percutaneous one. Left internal mammary artery (LIMA) is one of the best–performing vessels in CABG procedures due to its location and its own structural characteristics. Nevertheless, non–invasive assessment of its patency is challenging. Doppler Ultrasonography (DU) might perform as a reliable technique for non–invasive evaluation of the patency of LIMA. Data from literature revealed that DU may detect severe ( & gt;70%) stenosis of the LIMA graft. In this case, pulsed–wave Doppler might show peak diastolic velocity/peak systolic velocity & lt; 0.5 and diastolic fraction & lt; 50%). Stress test might also be adopted for the evaluation of patency of LIMA through DU. The aim of this narrative review is to evaluate the impact of DU on the evaluation of the patency of LIMA graft in patients who undergo follow–up after CABG intervention. The aim of this narrative review is to evaluate the impact of DU on the evaluation of the patency of LIMA graft in patients who undergo follow–up after CABG intervention.
    Type of Medium: Online Resource
    ISSN: 1520-765X , 1554-2815
    URL: Article
    DOI: 10.1093/eurheartjsupp/suad111.113
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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  • 8
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    Acute Myocarditis After Black Widow Spider Bite: A Case Report
    Springer Science and Business Media LLC ; 2020
    In:  Cardiology and Therapy Vol. 9, No. 2 ( 2020-12), p. 569-575
    Details
    In: Cardiology and Therapy, Springer Science and Business Media LLC, Vol. 9, No. 2 ( 2020-12), p. 569-575
    Type of Medium: Online Resource
    ISSN: 2193-8261 , 2193-6544
    URL: Article
    DOI: 10.1007/s40119-020-00178-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2700626-8
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  • 9
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    Using obese-specific charts of height and height velocity for assessment of growth in obese children and adolescents during weight excess reduction
    Springer Science and Business Media LLC ; 1999
    In:  European Journal of Clinical Nutrition Vol. 53, No. 3 ( 1999-03-01), p. 181-188
    Details
    In: European Journal of Clinical Nutrition, Springer Science and Business Media LLC, Vol. 53, No. 3 ( 1999-03-01), p. 181-188
    Type of Medium: Online Resource
    ISSN: 0954-3007 , 1476-5640
    URL: Article
    DOI: 10.1038/sj.ejcn.1600695
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1999
    detail.hit.zdb_id: 2004986-9
    SSG: 21
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  • 10
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    Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia
    S. Karger AG ; 2022
    In:  Acta Haematologica Vol. 145, No. 3 ( 2022), p. 334-343
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 145, No. 3 ( 2022), p. 334-343
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Leg ulcers are a frequent complication in patients with the inherited hemoglobin disorders. In thalassemia, the literature is limited, and factors associated with the development of leg ulcers in hemoglobin E (HbE) beta thalassemia, the most common form of severe beta-thalassemia worldwide, have not previously been reported. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We reviewed all available medical records of patients with HbE beta thalassemia to document the onset of leg ulcers at the 2 largest treatment centers in Sri Lanka. We reviewed the literature to identify studies reporting outcomes of interventions for ulcers in severe thalassemia. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of a total of 255 actively registered patients with HbE thalassemia in the 2 centers, 196 patient charts were evaluable. A leg ulcer with a documented date of onset was recorded in 45 (22%) of 196 evaluable patients, aged (mean ± SEM) 22.2 ± 1.4 years. Most had been irregularly transfused; steady-state hemoglobin was 6.4 ± 0.2 g/dL. Treatment achieving healing in 17 patients included transfusions, antibiotics, oral zinc, wound toileting, and skin grafting. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Leg ulcers may be more common in HbE beta thalassemia than in other forms of thalassemia. A systematic approach to treatment will be needed to document the prevalence and factors placing such patients at risk for leg ulcers. Controlled trials to evaluate the optimal treatment of this common complication are indicated.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000520731
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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