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  • 1
    Online Resource
    Online Resource
    Community acquired pneumonia of viral-bacterial etiology in young people: actual aspects of clinical and laboratory diagnostics
    ECO-Vector LLC ; 2018
    In:  Bulletin of the Russian Military Medical Academy Vol. 20, No. 3 ( 2018-12-15), p. 122-127
    Details
    In: Bulletin of the Russian Military Medical Academy, ECO-Vector LLC, Vol. 20, No. 3 ( 2018-12-15), p. 122-127
    Abstract: Community acquired pneumonia is one of the most topical acute respiratory diseases, which is caused by high incidence rate, especially in organized groups of people, constantly changing microbial flora, the increasing resistance of bacteria to antibacterial drugs, difficulties in etiological diagnostics, and the possibility of life-threatening complications and fatalities. An innovative algorithm of etiological diagnostics of community acquired pneumonia is suggested, which includes immunochromatography express-tests of sputum for viruses detection, bacteriological sputum culture, immunoenzyme assay of blood and polymerase chain reaction of sputum and blood serum. It is shown that standard bacteriological sputum culture did not allow us to reveal causative agents of community-acquired pneumonia timely and precisely in most cases, whereas the application of more comprehensive etiological diagnostics enabled us to reveal the causative agent in the majority of the examined patients. And express methods provided an opportunity to verify the infectious agent within 1-2 days and administer early effective etiotropic treatment. It is demonstrated that modern community acquired viral bacterial pneumonia has a number of clinical and laboratory features depending on the revealed viral agents. These features may be used as additional diagnostic criteria of the disease, especially when modern methods of etiological diagnostics are unavailable. The obtained results showed the effectiveness of the use of immunochromatography express-tests of sputum, polymerase chain reaction of sputum and blood serum, and immunoenzyme assay of blood. As a result of statistical analysis, a number of characteristic clinical and laboratory predictors of certain viral-bacterial associations of modern community acquired pneumonia was determined.
    Type of Medium: Online Resource
    ISSN: 2687-1424 , 1682-7392
    URL: Issue
    URL: Article
    DOI: 10.17816/brmma.373
    DOI: 10.17816/brmma12290
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2018
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  • 2
    Online Resource
    Online Resource
    THE INTERIM EXPERTS’ COUNCIL RESOLUTION ON THE EMPA-REG OUTCOME TRIAL ISSUES
    Silicea - Poligraf ; 2016
    In:  Rational Pharmacotherapy in Cardiology Vol. 12, No. 2 ( 2016-05-05), p. 186-190
    Details
    In: Rational Pharmacotherapy in Cardiology, Silicea - Poligraf, Vol. 12, No. 2 ( 2016-05-05), p. 186-190
    Type of Medium: Online Resource
    ISSN: 2225-3653 , 1819-6446
    URL: Issue
    URL: Article
    DOI: 10.20996/1819-6446-2016-12-2
    DOI: 10.20996/1819-6446-2016-12-2-186-190
    Language: Unknown
    Publisher: Silicea - Poligraf
    Publication Date: 2016
    detail.hit.zdb_id: 2750390-2
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Modern view on the etiology and immunological aspects of pneumonia
    Remedium, Ltd. ; 2023
    In:  Meditsinskiy sovet = Medical Council , No. 4 ( 2023-04-13), p. 141-153
    Details
    In: Meditsinskiy sovet = Medical Council, Remedium, Ltd., , No. 4 ( 2023-04-13), p. 141-153
    Abstract: Pneumonia is the most common and deadly nosology among all respiratory diseases associated with microorganisms. Despite advances in antibacterial and antiviral therapy, mortality due to pneumonia is not decreasing. It should be noted that the problem of infectious pathology has always been discussed only in narrow circles of specialists, which led to its underestimation, including during the pandemic of a new coronavirus infection. At present, scientific possibilities have not reached their perfection in the etiological diagnosis of pneumonia. Of no small concern is the lack of sections on immunology in the training program for general practitioners and pulmonologists and, as a result, the lack of knowledge by most medical specialists of the basics of the immune response in various infectious diseases, in particular, the differences in the immune response of a macroorganism in viral and bacterial infections, the stages of the immune response, differences between innate and adaptive immune responses, possibilities of immunocorrective therapy. Being followers  of the scientific school of pulmonology of academician N.S. Molchanov,  in this review, we evaluated the features of etiological factors and immune characteristics of the body on the course and out-comes of pneumonia, taking into account modern scientific knowledge. The current definition of pneumonia is formulated, the issues of the etiology of pneumonia from the perspective of the lung microbiome, the features of the immune response of the macroorganism in viral and bacterial pneumonia, the inconsistency of immune protection and the impact of comorbidity on this are covered in detail. Understanding the processes that lead to the disruption of the respiratory microbiome, the multiplication of pathobionts, the attachment of multiresistant microorganisms and the reactivity of the macroorganism will contribute to the development of new therapeutic approaches in the treatment of pneumonia.
    Type of Medium: Online Resource
    ISSN: 2658-5790 , 2079-701X
    URL: Article
    DOI: 10.21518/ms2023-056
    Language: Unknown
    Publisher: Remedium, Ltd.
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Rehabilitation after COVID-19. Resolution of the International Expert Council of the Eurasian Association of Therapists and the Russian Society of Cardiology
    Silicea - Poligraf, LLC ; 2021
    In:  Russian Journal of Cardiology Vol. 26, No. 9 ( 2021-10-19), p. 4694-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 26, No. 9 ( 2021-10-19), p. 4694-
    Abstract: By the middle of 2021, the official global number of coronavirus disease 2019 (COVID-19) patients was close to 230 million, but the number accounting for asymptomatic patients was much higher. Consequences and rehabilitation after COVID-19 are of particular interest and raise many controversial and unresolved issues. On May 18, 2021, the Eurasian Association of Therapists organized an international panel of experts to analyze challenges associated with the post-COVID-19 period. This panel aimed to develop approaches to identify gaps in the discussed issues. This interdisciplinary team of leading experts reviewed the current literature and presented their data to formulate practical guidance on management of patients after COVID-19. The panel of experts also presented recommendations on how to implement the gained knowledge into health care practices.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2021-9
    DOI: 10.15829/1560-4071-2021-4694
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    The agreed experts’ position of the Eurasian Association of Therapists on tactics of management of patients with comorbid pathology infected with SARS-Cov-2
    Consilium Medicum ; 2020
    In:  Terapevticheskii arkhiv Vol. 92, No. 9 ( 2020-10-14), p. 108-124
    Details
    In: Terapevticheskii arkhiv, Consilium Medicum, Vol. 92, No. 9 ( 2020-10-14), p. 108-124
    Abstract: The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail. The article presents data on drug interaction of drugs.
    Type of Medium: Online Resource
    ISSN: 2309-5342 , 0040-3660
    URL: Article
    DOI: 10.26442/00403660.2020.09.000703
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2020
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  • 6
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    Online Resource
    Diagnosis and differential diagnosis of pulmonary sarcoidosis
    ECO-Vector LLC ; 2018
    In:  Bulletin of the Russian Military Medical Academy Vol. 20, No. 1 ( 2018-03-15), p. 13-18
    Details
    In: Bulletin of the Russian Military Medical Academy, ECO-Vector LLC, Vol. 20, No. 1 ( 2018-03-15), p. 13-18
    Abstract: Pulmonary sarcoidosis is one of the most common interstitial lung diseases. The prevalence in Russia is 10-20 per 100 thousand population. Overwhelmingly it is found among working age population, and the peak of morbidity is 30-40 years. In half of the cases, sarcoidosis occurs in oligosymptomatic form. According to research conducted by our scientists, the adverse course of the disease with exacerbations and progressive decrease in pulmonary function found in 27,3% of patients. The diagnosis is based on clinical, X-ray and histological examination. Material for histological study was prepared depending on the extent of the process. Preference is given to minimally invasive methods of biopsy: transbronchial puncture of intrathoracic lymph nodes, peripheral lymph nodes, bone marrow aspiration, skin sarcoid items, etc. In the case of the intrathoracic localization of the disease, the treatment of choice is videothoracoscopy. The detection of epithelioid cell granuloma without necrosis confirms the diagnosis of sarcoidosis. First of all it is necessary to exclude tuberculosis, oncohematological diseases, disseminated lung diseases, combined with alveolitis syndrome and mediastinal lymphadenopathy. The primary diagnosis should be carried out under conditions of a multifunctional clinic. The verification of the pulmonary sarcoidosis should be held in close cooperation of different specialists: pulmonologists, radiologists, thoracic surgeons, pathologists, etc. Further treatment of the patient should be implemented by the pulmonologist in the place of residence. A clinical case of late diagnosis of diffuse diseases of connective tissue, which at its beginning started under the mask of sarcoidosis is demonstrated. The main mistake that led to deep disability of the patient, was absence of timely histological verification of the diagnosis.
    Type of Medium: Online Resource
    ISSN: 2687-1424 , 1682-7392
    URL: Issue
    URL: Article
    DOI: 10.17816/brmma.371
    DOI: 10.17816/brmma12191
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2018
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  • 7
    Online Resource
    Online Resource
    The role and place of glucocorticosteroids in treatment of COVID-19 pneumonia without hypoxemia
    Remedium, Ltd. ; 2021
    In:  Meditsinskiy sovet = Medical Council , No. 12 ( 2021-09-19), p. 162-172
    Details
    In: Meditsinskiy sovet = Medical Council, Remedium, Ltd., , No. 12 ( 2021-09-19), p. 162-172
    Abstract: Introduction . The article presents the problems of the use of glucocorticosteroids in the treatment of patients with coronavirus– associated pneumonia (COVID-19) without hypoxemia. The experience of the preemptive use of low doses of glucocorticosteroids in the treatment of such patients in a hospital is described. Simplification of a unified scheme of pathogenetic therapy with glucocorticosteroids in the above patients is urgent. The article highlights the effectiveness of the early use of low doses of glucocorticosteroids in the treatment of a specific cohort of patients with COVID-19. Objective . To assess the clinical efficacy and safety of early use of small doses of methylprednisolone in the comprehensive therapy of patients with moderate to severe COVID-19 pneumonia to prevent the development of complications and improve the outcomes of the disease. Materials and methods . The study included 40 hospitalized patients from 37 to 68 years (average age 52. years) with a diagnosis of moderate to severe COVID-19 pneumonia. Patients were randomized into two groups: the main group (n = 20) and the control group (n = 20). The main group additionally received methylprednisolone: 4 mg tablets, 7 tablets per day, divided into 2 doses (4 tablets in the morning and 3 tablets at lunchtime). The effectiveness of the therapy was evaluated based on the primary combined endpoint of the study, which included progression of the disease to an extremely severe form or the occurrence of pulmonary and extrapulmonary complications that required transfer to the intensive care unit, or death of the patient during the followup period. The secondary combined endpoint of the study was resolution of clinical symptoms of the disease or achievement of reference values of laboratory and instrumental indicators. Results . No lethal outcomes were observed in the compared groups, there were no cases of development of an extremely severe course, complications requiring transfer to the intensive care unit in the main group. Conclusion . Early use of small doses methylprednisolone of in comprehensive therapy of patients with moderate and severe COVID-19 pneumonia reduces the incidence of life-threatening complications and improves the outcomes of the disease. 
    Type of Medium: Online Resource
    ISSN: 2658-5790 , 2079-701X
    URL: Article
    DOI: 10.21518/2079-701X-2021-12-162-172
    Language: Unknown
    Publisher: Remedium, Ltd.
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    Multifaceted properties of erdostein and its place in the treatment of respiratory tract diseases
    Remedium, Ltd. ; 2022
    In:  Meditsinskiy sovet = Medical Council Vol. 16, No. 18 ( 2022-10-15), p. 82-89
    Details
    In: Meditsinskiy sovet = Medical Council, Remedium, Ltd., Vol. 16, No. 18 ( 2022-10-15), p. 82-89
    Abstract: Mucoactive drugs are commonly used in  the treatment of  respiratory diseases such as chronic bronchitis  (CB) or chronic obstructive pulmonary disease (COPD), in which hypercrinia is one of the main clinical features. Erdostein is one of the most commonly used mucoactive agents for the treatment of respiratory diseases. Erdostein is a drug approved for the treatment of acute and chronic lung diseases, originally developed as a mucolytic agent. It belongs to a family of thiol-based drugs, which, in  addition to mucolytic action, also have antioxidant and anti-inflammatory properties and exhibit antibacterial activity against various types of bacteria. Erdosteine is a prodrug that is converted to the active metabolite M1 (MET 1), which has mucolytic properties. Experimental studies have confirmed that erdosteine prevents or reduces damage to lung tissue caused by oxidative stress, and also regulates the production of reactive oxygen species. The RESTORE study, the only study that examined the effect of a thiol-based drug in chronic obstructive pulmonary disease (COPD) with frequent exacerbations, confirmed that erdosteine significantly reduces the risk of acute exacerbations of COPD, reduces their duration, and also reduces the risk of hospitalization for COPD. The preventive effect of erdosteine against exacerbations of COPD was not affected by the presence or absence of inhaled corticosteroids (ICS) or the number of eosinophils in the blood. Recent studies on the pharmacological effects of erdosteine have shown promising results, which paves the way for the use of additional pharmacological effects of erdosteine as promising therapeutic strategies in patients with pulmonary diseases.
    Type of Medium: Online Resource
    ISSN: 2658-5790 , 2079-701X
    URL: Article
    DOI: 10.21518/2079-701X-2022-16-18-82-89
    Language: Unknown
    Publisher: Remedium, Ltd.
    Publication Date: 2022
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  • 9
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    Online Resource
    Resolution of the International meeting of experts on the exchange of scientific experience in the use of anticoagulants in patients with COVID-19
    Silicea - Poligraf, LLC ; 2020
    In:  Russian Journal of Cardiology Vol. 25, No. 9 ( 2020-09-21), p. 92-94
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 25, No. 9 ( 2020-09-21), p. 92-94
    Abstract: С целью получения экспертного мнения по вопросам, связанным с актуальностью, протоколами и режимами антитромботической терапии у пациентов с COVID-19 на госпитальном и амбулаторном этапах лечения 25 июля 2020г была проведена Международная он-лайн встреча экспертов по научному обмену опытом. Группа экспертов различных специальностей (кардиологи, неврологи, эндокринологи, анестезиологи-реаниматологи), имеющих клинический опыт лечения пациентов с COVID-19, ответила на вопросы, касающиеся использования антикоагулянтов на различных этапах оказания помощи при COVID-19. Учитывая недостаточное количество структурированной научной информации, отсутствие рандомизированных контролируемых исследований в области использования антикоагулянтов у пациентов с COVID-19, наличие различных мнений в профессиональных медицинских сообществах было принято решение провести голосование с использованием Дельфийского метода экспертных оценок и прогнозирования. На первом этапе для экспертов формировались вопросы, которые касались нескольких областей терапии: тактика ведения больных, постоянно принимавших антикоагулянты до заболевания COVID-19, назначение антикоагулянтной терапии больным по поводу COVID-19 и особенности назначения антикоагулянтной терапии у больных с высоким риском венозной тромбоэмболии при COVID-19. После утверждения списка вопросов проводилось анонимное анкетирование экспертов вне очной встречи и затем обрабатывались полученные результаты, определяя обычное большинство при голосовании по каждому вопросу.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2020-9
    DOI: 10.15829/1560-4071-2020-4099
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2020
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  • 10
    Online Resource
    Online Resource
    Viral pneumonia: a new look at an old problem (review)
    Remedium, Ltd. ; 2021
    In:  Meditsinskiy sovet = Medical Council , No. 16 ( 2021-10-29), p. 60-77
    Details
    In: Meditsinskiy sovet = Medical Council, Remedium, Ltd., , No. 16 ( 2021-10-29), p. 60-77
    Abstract: The relevance of pneumonia remains at the forefront and has recently attracted the attention of not only the entire medical community, but also all political and economic institutions of most countries of the planet. This nosology continues to be in the center of attention, identifying one of the key causes in the frequency of mortality of the population. The presented article accumulates the most up-to-date theses regarding viral pneumonia on the basis of a review of a large number of scientific literature, domestic and foreign studies. Although the term “viral pneumonia” has been used in medical practice for more than a century, nevertheless, there is no final diagnostic algorithm and an established final concept. The article reflects special historical medical and philosophical aspects in the study of pneumonia from the time of Hippocrates to the present. The epidemiological features, etiology, and also the terminological base of viral pneumonia are updated, thereby the concept of viral pneumonia in medical categories is fixed. A promising classification of viral pneumonia according to ICD-XI is presented. Attention is drawn to the autopsy morphological characteristics of the bronchopulmonary organ complex in viral pneumonia, post-mortem descriptions are given with links to authoritative research sources. The main modern diagnostic capabilities of the scientific medical community in the detection of pneumonia are described, the issues of the formation of new diagnostic algorithms are reflected. The clinical picture of viral pneumonia is described in detail, the clinical concept of the phase course of the disease based on pathomorphological data is presented for the first time. The main modern groups of drugs for etiotropic and pathogenetic treatment of the disease are considered. The conclusion reflects the main problematic postulates and prospects for further study of the disease.
    Type of Medium: Online Resource
    ISSN: 2658-5790 , 2079-701X
    URL: Article
    DOI: 10.21518/2079-701X-2021-16-60-77
    Language: Unknown
    Publisher: Remedium, Ltd.
    Publication Date: 2021
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