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  • 1
    Online Resource
    Online Resource
    Hepatic Histologic Changes in Patients with Chronic Hepatitis B Virus Infection with High DNA Level and Normal or Minimally Elevated Alanine Aminotransferase
    Bangladesh Academy of Sciences ; 2016
    In:  Faridpur Medical College Journal Vol. 10, No. 1 ( 2016-05-30), p. 3-8
    Details
    In: Faridpur Medical College Journal, Bangladesh Academy of Sciences, Vol. 10, No. 1 ( 2016-05-30), p. 3-8
    Abstract: Hepatitis B Virus (HBV) infection can causes spectrum of diseases ranging from clinically asymptomatic state to the development of cirrhosis and hepatocellular carcinoma (HCC). There is ongoing debate in the management of asymptomatic patients with chronic hepatitis B virus (CHBV) infection with high DNA and normal ALT level. It has been recently shown that a significant proportion of patients with CHBV infection with high DNA and normal ALT level have significant histological abnormality. So this study was aimed to see the histological changes in patients with CHBV infection with high DNA and ALT level 〈 2 times of upper limit of normal (ULN). Total 64 patients were included in this cross sectional study. Mean age was 29 years, 55 (85.9%) patients were men. Forty patients (62.5%) were HBeAg positive. Thirty seven (57.8%) patients had normal ALT levels and 27 patients (42.2%) had ALT levels 1-2 x ULN. Out of 64 patients 46.8% had significant histological abnormalities. Among them 31.2% had significant fibrosis and 26.5% had significant necroinflammatory changes. Among 37 patients with normal ALT levels 35% had significant histological abnormalities. But among 27 patients with ALT levels of 1-2 x ULN, 63% had significant histological abnormalities. In this series significant histological abnormalities were found in 40% of HBeAg+ve cases and 58.3% of HBeAg-ve cases. But this difference was not statistically significant. It was also found that patients with significant histological abnormalities were significantly older and had a lower median HBV DNA level, lower mean platelet count, lower mean prothrombin activity ratio and lower mean albumin level than patients with nonsignificant histological changes. In logistic regression analysis it was found that serum ALT levels and age at which patients entered the study were independently associated with the risk for significant histological abnormalities.Faridpur Med. Coll. J. Jan 2015;10(1): 3-8
    Type of Medium: Online Resource
    ISSN: 2079-3553
    URL: Article
    DOI: 10.3329/fmcj.v10i1.27915
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2016
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  • 2
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    Efficacy of Different Laboratory Tests to Diagnose Helicobacter pylori Infection
    Bangladesh Academy of Sciences ; 2013
    In:  Faridpur Medical College Journal Vol. 8, No. 1 ( 2013-11-07), p. 11-14
    Details
    In: Faridpur Medical College Journal, Bangladesh Academy of Sciences, Vol. 8, No. 1 ( 2013-11-07), p. 11-14
    Abstract: Helicobacter pylori is a Gram negative bacteria which causes chronic gastritis, peptic ulcer disease, primary B-cell gastric lymphoma, and adenocarcinoma of the stomach. There are a set of laboratory tests to diagnose H. pylori infection with a variable accuracy, they are divided into non-invasive tests and invasive tests. Non-invasive tests include serology, urea breath test (UBT) and stool antigen test (SAT). Invasive tests include rapid urease test (RUT), histology and culture. This cross sectional study was carried out in the Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and H. pylori laboratory of International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) from July 2008 to September 2009 to evaluate the efficacy of RUT, SAT and Culture as a diagnostic tool for H. pylori. Dyspeptic patients were collected from outpatient department of BSMMU. Out of 224 dyspeptic patients 149 patients had ulcers or erosions in the stomach or duodenum. Stool sample could be collected from 139 patients. RUT has sensitivity of 100%, specificity 80.28%, positive predictive value 85% and negative predictive value 100%. Regarding culture, sensitivity is 100%, specificity 94.37%, positive predictive value 95% and negative predictive value 100%. Stool antigen test has sensitivity 95.94%, specificity 92.31%,positive predictive value 93% and negative predictive value 95%. DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16890 Faridpur Med. Coll. J. 2013;8(1): 11-14
    Type of Medium: Online Resource
    ISSN: 2079-3553
    URL: Article
    DOI: 10.3329/fmcj.v8i1.16890
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
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  • 3
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    Online Resource
    Seroprevalence of Hepatitis C Virus in Thalassemic Patients
    Bangladesh Academy of Sciences ; 1970
    In:  Journal of Dhaka Medical College Vol. 18, No. 2 ( 1970-01-01), p. 115-119
    Details
    In: Journal of Dhaka Medical College, Bangladesh Academy of Sciences, Vol. 18, No. 2 ( 1970-01-01), p. 115-119
    Abstract: Hepatitis C virus is one of the leading causes of liver disease and represents a major public health problem. It is a common cause of cirrhosis and hepatocellular carcinoma (HCC) as well as the most common reason for liver transplantation. This cross sectional study was carried out during the period of April 2007 to April 2008 among thalassemic patients with history of multiple blood transfusion ( 〉 20 units). Total 200 thalassemic patients from Thalassemia Samity Hospital, Green Road, Bangladesh Thalassemia Foundation, Dhanmondi, and from Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka were included in the study.After taking detailed history and clinical examination , 0.3 ml of venous blood was collected from each patient and tested for anti HCV by commercial kit. Positive cases were confirmed by ELISA method. Among 200 patients majority (68.5%) were below age of 20 years with a male to female ratio of 1.7:1,16.5% were found to have anti HCV positive. Anti HCV positivity increased with duration of exposure and number of blood transfusion., 22.9% of patients who had duration of exposure for more than 10 years and 36.4% having blood transfusion more than 40 units were positive for anti HCV. Key words: Seroprevalence; hepatitis C virus; thalassemia. DOI: 10.3329/jdmc.v18i2.6269 J Dhaka Med Coll. 2009; 18(2) : 115- 119
    Type of Medium: Online Resource
    ISSN: 2219-7494 , 1028-0928
    URL: Article
    DOI: 10.3329/jdmc.v18i2.6269
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 1970
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  • 4
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    Online Resource
    Symptomatic overlap in patients with diarrhea predominant irritable bowel syndrome and microscopic colitis in a sub group of Bangladeshi population
    Bangladesh Academy of Sciences ; 2012
    In:  Bangladesh Medical Research Council Bulletin Vol. 38, No. 1 ( 2012-04-22), p. 33-38
    Details
    In: Bangladesh Medical Research Council Bulletin, Bangladesh Academy of Sciences, Vol. 38, No. 1 ( 2012-04-22), p. 33-38
    Abstract: Microscopic Colitis (MC) and diarrhea predominant irritable bowel syndrome (IBS-D) has almost similar clinical feature but MC is diagnosed by histologic criteria and IBS is diagnosed by symptombased criteria. There is ongoing debate about the importance of biopsies from endoscopically normal colonic mucosa in the investigation of patients with IBS-D. Aim of this study was to assess the prevalence of MC in patient with IBS-D and to determine the distribution of MC in the colon. This observational study was conducted in department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2008 to December 2009. Patients were evaluated thoroughly & who meet RomeII criteria with normal routine laboratory tests, were included in the study. Colonoscopy was done and biopsies were taken from the caecum, transverse colon, descending colon, and rectum. Out of total 60 patients, 22 had Lymphocytic Colitis (LC), 28 had nonspecific microscopic colitis (NSMC) and 10 had irritable bowel syndrome noninflamed (IBSNI). The distribution of LC was restricted to proximal colon in 15 patients, in the left colon in 2 patients and diffuses throughout the colon in 5 patients. There is considerable symptom overlap between the patients of IBS-D and patients with microscopic colitis. Without colonoscopic biopsy from multiple sites, possibility of MC cannot be excluded in patients with IBS-D and it can be said that clinical symptom based criteria for irritable bowel syndrome are not sufficient enough to rule out the diagnosis of microscopic colitis. DOI: http://dx.doi.org/10.3329/bmrcb.v38i1.10450 Bangladesh Med Res Counc Bull 2012; 38: 33-38
    Type of Medium: Online Resource
    ISSN: 2224-7238 , 0377-9238
    URL: Article
    DOI: 10.3329/bmrcb.v38i1.10450
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2012
    detail.hit.zdb_id: 2491184-7
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  • 5
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    Online Resource
    Risk Factor for Relapse in Childhood Nephrotic Syndrome - A Hospital Based Retrospective Study
    Bangladesh Academy of Sciences ; 2012
    In:  Faridpur Medical College Journal Vol. 7, No. 1 ( 2012-04-08), p. 18-22
    Details
    In: Faridpur Medical College Journal, Bangladesh Academy of Sciences, Vol. 7, No. 1 ( 2012-04-08), p. 18-22
    Abstract: Nephrotic Syndrome (NS) is a common childhood illness characterized by massive proteinuria, hyperlipidemia, hypoalbuminemia & edema. NS is a disease of relapse and it is a major problem to manage the cases with frequent relapse. So it is very important to find out such children who are prone to develop frequent relapse. This retrospective study was conducted in the paediatric department of Dhaka Medical College Hospital (DMCH) from January to December 2005.Total 100 children with relapsed NS of them 50 had Frequent Relapse NS (FRNS) and 50 had Infrequent Relapse NS (IFRNS) were included in the study with a view to find out the risk factors for relapse. Data were collected from previous medical and hospital records. Data were analyzed by using SPSS program. Chi-squared test and Student's t-Test were used as statistical test and p value 〈 0.05 was taken as significant. NS was more common among 2-6 years of age (67%) with male to female ratio roughly 2:1. Most of patient with frequent relapse had age 〈 5 years, came from rural area and belongs to poor social class compared to that of infrequent relapse. The mean age at first onset was significantly less in frequent relapse group than that of infrequent relapse group. Majority of atopic child belongs to frequent relapse cases. Low serum albumin level, low serum total protein level, culture positive Urinary Tract Infection (UTI) at initial attack were observed to be statistically significant in case of frequent relapse group.DOI: http://dx.doi.org/10.3329/fmcj.v7i1.10292Faridpur Med. Coll. J. 2012;7(1): 18-22
    Type of Medium: Online Resource
    ISSN: 2079-3553
    URL: Article
    DOI: 10.3329/fmcj.v7i1.10292
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2012
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  • 6
    Online Resource
    Online Resource
    Antimicrobial Sensitivity Pattern of Helicobacter pylori Isolates among Subgroup of Bangladeshi Patients
    Bangladesh Academy of Sciences ; 2014
    In:  Faridpur Medical College Journal Vol. 8, No. 2 ( 2014-09-01), p. 49-52
    Details
    In: Faridpur Medical College Journal, Bangladesh Academy of Sciences, Vol. 8, No. 2 ( 2014-09-01), p. 49-52
    Abstract: This cross sectional study was carried out at Bangabandhu Sheikh Mujib Medical University (BSMMU) and International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) from July 2008 to September 2009. Aim of the study was to find out the antimicrobial susceptibility profile of Helicobacter pylori isolates from dyspeptic patients. Total 224 dyspeptic patients from Out Patient Department (OPD) of BSMMU were initially enrolled after informed written consent. After upper GI endoscopy 157 patients were finally included who had erosions, ulcers or atrophic changes in the stomach or duodenum. Two biopsy samples were taken from each of them. Samples were incubated at 37°C in a double gas incubator with 5%O2, 10%CO2 and 85%N2. Total 82 (52.23%) samples were found positive for H. pylori. Isolated organisms were then tested for sensitivity to Amoxicillin, Clarithromycin, Tetracycline, Levofloxacin and Metronidazole by Agar dilution method. Among 82 patients 51(62.2%) were male and 31(37.8) were female with a male:female ratio 1.6:1. Patients were categorized into two groups one having gastric or duodenal ulcer (30.5%) and other having no ulcer (69.5%). Among these isolates 92.7% were sensitive to Amoxicillin, 89% to Clarithromycin, 81.7% to Tetracycline, 80.5% to Levofloxacin and only 26.8% to Metronidazole. Beside these, 81.7% isolates were sensitive to both Amoxicillin and Clarithromycin, 74.4% to Amoxicillin and Tetracycline, 73.2% to Amoxicillin and Levofloxacin, 72% to Clarithromycin and Tetracycline, 59% to Clarithromycin and Levofloxacin and 51% to Tetracycline and Levofloxacin DOI: http://dx.doi.org/10.3329/fmcj.v8i2.20280 Faridpur Med. Coll. J. 2013;8(2): 49-52
    Type of Medium: Online Resource
    ISSN: 2079-3553
    URL: Article
    DOI: 10.3329/fmcj.v8i2.20280
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2014
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  • 7
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    Online Resource
    Seroprevalence of Hepatitis C Virus among Health Care Workers
    Bangladesh Academy of Sciences ; 1970
    In:  Journal of Dhaka Medical College Vol. 18, No. 1 ( 1970-01-01), p. 70-74
    Details
    In: Journal of Dhaka Medical College, Bangladesh Academy of Sciences, Vol. 18, No. 1 ( 1970-01-01), p. 70-74
    Abstract: Context: Hepatitis C virus is one of the leading causes of liver disease and represents a major public health problem. It is a common cause of cirrhosis and hepatocellular carcinoma (HCC) as well as the most common reason for liver transplantation. Methods: A cross sectional study was carried out during the period of April 2007 to April 2008 among health care workers including phlebotomists, dialysis staffs and laboratory personnel handling blood and blood products. Total 200 health care workers from phlebotomists working at one stop collection centre of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Medical College Hospital (DMCH), Dialysis staff working at haemodialysis units of BSMMU, Bangladesh Institute of Rehabilitation for Diabetes, Endocrine & Metabolic Diseases (BIRDEM), DMCH, National Institute of Kidney Diseases & Urology (NIKDU) had at least more than one year working exposure was enrolled in this study. After taking informed written consent detailed history was taken, clinical examination was done. 0.3 ml of venous blood was collected from each patient and tested for anti HCV by commercial kit, confirmed by ELISA method. Result: Among 200 patients majority (55.5%) of patients were below 30 years of age and there was equal prevalence among male and female. Out of 200 health care workers 1% was found to be anti HCV positive. All positive patient had duration of exposure of 〉 5 years and had history of needle stick injury. Key words: Hepatitis C virus; seroprevalence; health care workers. DOI: 10.3329/jdmc.v18i1.6310 J Dhaka Med Coll. 2009; 18(1) : 70-74
    Type of Medium: Online Resource
    ISSN: 2219-7494 , 1028-0928
    URL: Article
    DOI: 10.3329/jdmc.v18i1.6310
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 1970
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