In:
Magnetic Resonance in Medicine, Wiley, Vol. 87, No. 1 ( 2022-01), p. 50-56
Abstract:
To demonstrate J ‐difference editing of phosphorylethanolamine (PE) with chemical shifts at 3.22 (PE 3.22 ) and 3.98 (PE 3.98 ) ppm, and compare the merits of two editing strategies. Methods Density‐matrix simulations of MEGA‐PRESS (Mescher‐Garwood PRESS) for PE were performed at TEs ranging from 80 to 200 ms in steps of 2 ms, applying 20‐ms editing pulses (ON/OFF) at (1) 3.98/7.5 ppm to detect PE 3.22 and (2) 3.22/7.5 ppm to detect PE 3.98 . Phantom experiments were performed using a PE phantom to validate simulation results. Ten subjects were scanned using a Philips 3T MRI scanner at TEs of 90 ms and 110 ms to edit PE 3.22 and PE 3.98 . Osprey was used for data processing, modeling, and quantification. Results Simulations show substantial TE modulation of the intensity and shape of the edited signals due to coupling evolution. Simulated and phantom integrals suggest that TEs of 110 ms and 90 ms were optimal for the edited detection of PE 3.22 and PE 3.98 , respectively. Phantom results indicated strong agreement with the simulated spectra and integrals. In vivo quantification of the PE 3.22 /total creatine and PE 3.98 /total creatine concentration ratio yielded values of 0.26 ± 0.04 (between‐subject coefficient of variation [CV]: 15.4%) and 0.18 ± 0.04 (CV: 22.8%), respectively, at TE = 90 ms, and 0.24 ± 0.02 (CV: 8.2%) and 0.23 ± 0.04 (CV: 18.0%), respectively, at TE = 110 ms. Conclusion Simulations and in vivo MEGA‐PRESS of PE demonstrate that both PE 3.22 and PE 3.98 are potential candidates for editing, but PE 3.22 at TE = 110 ms yields lower variation across TEs. Keywords: Magnetic resonance spectroscopy, MEGA‐PRESS, spectral editing, phosphorylethanolamine
Type of Medium:
Online Resource
ISSN:
0740-3194
,
1522-2594
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1493786-4
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