In:
The FASEB Journal, Wiley, Vol. 22, No. S1 ( 2008-03)
Abstract:
Purpose: Erythropoietin (EPO) is a hormone regulating red blood cell production. Recently it is known that Epo enhances the angiogenesis. However, since shear stress is an initiator of arteriogenesis, Epo may increase arteriogenesis due to increased shear stress by erythrocytosis. From these backgrounds, we compared the effect of Epo on both angiogenesis and arteriogenesis. Methods: Myocardial infarction was prepared by LAD ligation in Wistar rat (Epo and control, each n=8). Epo (1,000 IU/kg) was administrated immediately after ligation. 4 weeks later, coronary angiography was performed using synchrotron radiation coronary microangiography. Numbers of vessels were also investigated by microscopy. Arteriogenesis was defined as number of arteriole ( 〉 100 um) and angiogenesis was defined as number of capillaries ( 〈 50 um). Results: Pathology: In capillary number, Epo increased 184% at border zone compared with intact area, whereas control increased 155% (p 〈 0.05 vs. Epo). On the other hand, in arteriole number, Epo increased 594%, whereas control was 223% (p 〈 0.00001 vs. Epo) in the same area. Angiography: Epo enhanced number of arterioles in border zone than control significantly (5.4+/−1.7 vs. 3.8+/−0.4 per 2 mm^2, p 〈 0.05). Conclusion: Epo enhances arteriogenesis rather than angiogenesis in infarcted rat heart.
Type of Medium:
Online Resource
ISSN:
0892-6638
,
1530-6860
DOI:
10.1096/fasebj.22.1_supplement.746.16
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
1468876-1
detail.hit.zdb_id:
639186-2
SSG:
12
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