In:
Intervirology, S. Karger AG, Vol. 65, No. 1 ( 2022), p. 49-57
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The literature search was based on keywords including “chronic fatigue syndrome and HHV 6,” “chronic fatigue syndrome and HHV-6,” “chronic fatigue syndrome and HHV6,” “chronic fatigue syndrome and Herpes virus 6,” and “chronic fatigue syndrome and Herpesvirus6” in MEDLINE (PubMed), Web of Science, and EMBASE. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger’s test ( 〈 i 〉 p 〈 /i 〉 value = 0.2) identified no publication bias among studies. Moreover, the low level of 〈 i 〉 I 〈 /i 〉 〈 sup 〉 2 〈 /sup 〉 revealed homogeneity across studies. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.
Type of Medium:
Online Resource
ISSN:
0300-5526
,
1423-0100
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
1482863-7
SSG:
12
Permalink