In:
Journal of Clinical Periodontology, Wiley, Vol. 41, No. 5 ( 2014-05), p. 460-466
Abstract:
The purpose of this study was to elucidate whether the association between beta‐3 adrenergic receptor polymorphism and periodontal disease is modified by body weight. Material and Methods We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta‐3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level ( CAL ) were measured. After selecting subjects for each body mass index ( BMI ) level, the prevalence rate ratio ( PRR ) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta‐3 adrenergic receptor polymorphism. The number of sites with CAL ≥6 mm was used as a dependent variable, and beta‐3 adrenergic receptor genotype [categorized as Arg non‐carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites ( n ) to an offset variable. Results The PRR of the beta‐3 adrenergic receptor genotype for the number of sites of CAL ≥6 mm showed a positive association in subjects with BMI ≥25.0 and increased markedly with BMI . The PRR in subjects with BMI ≥30 was 3.10 ( p 〈 0.0001). Conclusion This study indicates a positive association between periodontal disease and the beta‐3 adrenergic receptor genotype in obese individuals.
Type of Medium:
Online Resource
ISSN:
0303-6979
,
1600-051X
DOI:
10.1111/jcpe.2014.41.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2026349-1
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