In:
Diseases of the Colon & Rectum, Ovid Technologies (Wolters Kluwer Health), Vol. 60, No. 8 ( 2017-08), p. 827-836
Abstract:
The influence of postoperative infectious complications, such as anastomotic leakage, on survival has been reported for various cancers, including colorectal cancer. However, it remains unclear whether intra-abdominal/pelvic inflammation after radical surgery for locally recurrent rectal cancer is relevant to its prognosis. OBJECTIVE: The purpose of this study was to evaluate factors associated with survival after radical surgery for locally recurrent rectal cancer. DESIGN: The prospectively collected data of patients were retrospectively evaluated. SETTINGS: This study was conducted at a single-institution tertiary care cancer center. PATIENTS: Between 1983 and 2012, patients who underwent radical surgery for locally recurrent rectal cancer with curative intent at the National Cancer Center Hospital were reviewed. MAIN OUTCOME MEASURES: Factors associated with overall and relapse-free survival were evaluated. RESULTS: During the study period, a total of 180 patients were eligible for analyses. Median blood loss and operation time for locally recurrent rectal cancer were 2022 mL and 634 minutes. Five-year overall and 3-year relapse-free survival rates were 38.6% and 26.7%. Age ( p = 0.002), initial tumor stage ( p = 0.03), pain associated with locally recurrent rectal cancer ( p = 0.03), CEA level ( p = 0.004), resection margin ( p 〈 0.001), intra-abdominal/pelvic inflammation ( p 〈 0.001), and surgery period ( p = 0.045) were independent prognostic factors associated with overall survival, whereas CEA level ( p = 0.01), resection margin ( p = 0.002), and intra-abdominal/pelvic inflammation ( p = 0.001) were associated with relapse-free survival. Intra-abdominal/pelvic inflammation was observed in 45 patients (25.0%). A large amount of perioperative blood loss was the only factor associated with the occurrence of intra-abdominal/pelvic inflammation ( p = 0.007). LIMITATIONS: This study was limited by its retrospective nature and heterogeneous population. CONCLUSIONS: Intra-abdominal/pelvic inflammation after radical surgery for locally recurrent rectal cancer is associated with poor prognosis. See Video Abstract at http://journals.lww.com/dcrjournal/Pages/videogallery.aspx.
Type of Medium:
Online Resource
ISSN:
0012-3706
DOI:
10.1097/DCR.0000000000000853
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2017
detail.hit.zdb_id:
2046914-7
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