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  • 1
    Online Resource
    Online Resource
    Preoperative nomogram for identifying invasive pulmonary adenocarcinoma in patients with pure ground-glass nodule: A multi-institutional study
    Impact Journals, LLC ; 2017
    In:  Oncotarget Vol. 8, No. 10 ( 2017-03-07), p. 17229-17238
    Details
    In: Oncotarget, Impact Journals, LLC, Vol. 8, No. 10 ( 2017-03-07), p. 17229-17238
    Type of Medium: Online Resource
    ISSN: 1949-2553
    URL: Issue
    URL: Article
    DOI: 10.18632/oncotarget.v8i10
    DOI: 10.18632/oncotarget.11236
    Language: English
    Publisher: Impact Journals, LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2560162-3
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  • 2
    Online Resource
    Online Resource
    Uric Acid Levels and All-Cause Mortality in Peritoneal Dialysis Patients
    S. Karger AG ; 2013
    In:  Kidney and Blood Pressure Research Vol. 37, No. 2-3 ( 2013), p. 181-189
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 37, No. 2-3 ( 2013), p. 181-189
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Epidemiological studies have shown that hyperuricemia is associated with all-cause and cardiovascular mortality in chronic kidney disease (CKD) and hemodialysis patients. Our study investigated the influence of serum uric acid (UA) levels on survival in peritoneal dialysis (PD) patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This was a retrospective study involving 156 subjects who had undergone PD. The patient demographics, etiology of ESRD, comorbid conditions and other laboratory parameters were collected. The subjects were divided into three groups according to their serum UA concentrations (group 1, the lowest quartile; group 2, the middle quartiles; group 3, the highest quartile). The risk of death was calculated using a multivariate Cox regression model. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There were 41 deaths during a follow-up period of 31.3±17.5 months. Compared with group 2, which had a mortality rate of 5.7 per 1000 person-months, the mortality rates were higher in group 1 (14.3 per 1000 person-months, p 〈 0.05) and group 3 (13.3 per 1000 person-months, p 〈 0.05). A multivariable Cox regression model revealed that age, serum albumin, diabetes mellitus (DM), hypertensive nephropathy, residual renal function and UA group were factors associated with mortality in the PD patients. Using group 2 as a reference, the hazard ratio (HR) of mortality was found to be 1.15 (95% confidence interval [CI] 0.20-2.57, p 〉 0.05) for group 1 and 2.96 (95% CI 1.29-6.80, p=0.01) for group 3. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In PD patients, a higher serum UA level is related to increased mortality and is an independent risk factor for all-cause mortality. Uric acid levels and all-cause mortality in peritoneal dialysis patients.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000350143
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482922-8
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  • 3
    Online Resource
    Online Resource
    Development and validation of a nomogram to estimate the pretest probability of cancer in Chinese patients with solid solitary pulmonary nodules: A multi‐institutional study
    Wiley ; 2017
    In:  Journal of Surgical Oncology Vol. 116, No. 6 ( 2017-11), p. 756-762
    Details
    In: Journal of Surgical Oncology, Wiley, Vol. 116, No. 6 ( 2017-11), p. 756-762
    Abstract: To develop and validate a nomogram to estimate the pretest probability of malignancy in Chinese patients with solid solitary pulmonary nodule (SPN). Materials and Methods A primary cohort of 1798 patients with pathologically confirmed solid SPNs after surgery was retrospectively studied at five institutions from January 2014 to December 2015. A nomogram based on independent prediction factors of malignant solid SPN was developed. Predictive performance also was evaluated using the calibration curve and the area under the receiver operating characteristic curve (AUC). Results The mean age of the cohort was 58.9 ± 10.7 years. In univariate and multivariate analysis, age; history of cancer; the log base 10 transformations of serum carcinoembryonic antigen value; nodule diameter; the presence of spiculation, pleural indentation, and calcification remained the predictive factors of malignancy. A nomogram was developed, and the AUC value (0.85; 95%CI, 0.83‐0.88) was significantly higher than other three models. The calibration cure showed optimal agreement between the malignant probability as predicted by nomogram and the actual probability. Conclusions We developed and validated a nomogram that can estimate the pretest probability of malignant solid SPNs, which can assist clinical physicians to select and interpret the results of subsequent diagnostic tests.
    Type of Medium: Online Resource
    ISSN: 0022-4790 , 1096-9098
    URL: Issue
    URL: Article
    DOI: 10.1002/jso.v116.6
    DOI: 10.1002/jso.24704
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1475314-5
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  • 4
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    Online Resource
    Risk Factor Analysis of Calcification in Aortic and Mitral Valves in Maintenance Peritoneal Dialysis Patients
    S. Karger AG ; 2013
    In:  Kidney and Blood Pressure Research Vol. 37, No. 4-5 ( 2013), p. 488-495
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 37, No. 4-5 ( 2013), p. 488-495
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 This study aimed to investigate potential risk factors for calcification in aortic and mitral valves in maintenance peritoneal dialysis (MPD) patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We enrolled MPD patients who had undergone over 18 months of dialysis in our dialysis center, examined their cardiac valve calcification status by echocardiography, and recorded their biochemical data and dialysis-related indicators. These results were compared by logistic regression analyses to identify the risk factors associated with calcification in aortic and mitral valves. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 117 enrolled MPD patients, 41 exhibited calcification in aortic or mitral valves, including 38 with aortic valve calcification (AVC) and 17 with mitral valve calcification (MVC); 14 of them had calcification in both aortic and mitral valves. Multivariate logistic regression analysis revealed that age (OR=1.965, p=0.01), diabetes history (OR=4.693, p=0.029), calcium-phosphorus product (OR=2.373, p=0.001) and prealbumin (OR=0.908, p=0.012) were independently related to AVC, whereas age (OR=3.179, p=0.023), calcium-phosphorus product (OR=6.512, p=0.001), prealbumin (OR=0.885, p=0.033), high-density lipoprotein (OR=19.540, p=0.011) and diabetes history (OR=6.948, p=0.038) were independently related to MVC. 〈 b 〉 〈 i 〉 Conclusions 〈 /i 〉 〈 /b 〉 The incidence of cardiac valve calcification in MPD patients is high, and the incidence of AVC is higher than MVC. Age, diabetes history, calcium-phosphorus product and hypo-prealbuminemia are independent risk factors for AVC, whereas age, calcium-phosphorus product and hypo-prealbuminemia are independent risk factors for MVC.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000355729
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482922-8
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  • 5
    Online Resource
    Online Resource
    Tailoring exciton dynamics of monolayer transition metal dichalcogenides by interfacial electron-phonon coupling
    Springer Science and Business Media LLC ; 2019
    In:  Communications Physics Vol. 2, No. 1 ( 2019-09-02)
    Details
    In: Communications Physics, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2019-09-02)
    Abstract: With their strong light-matter interaction and rich photo-physics, two-dimensional (2D) transition metal dichalcogenides (TMDs) are important candidates for novel photonic and spin-valleytronic devices. It is highly desirable to control the photocarrier behaviours of monolayer TMDs to suit the needs of device functionalities. Here, through interfacial engineering, i.e., by depositing monolayer MoSe 2 onto different oxide substrates (SiO 2 , Al 2 O 3 and HfO 2 ), we have revealed large tuning of the exciton relaxation times in monolayer TMDs. Significantly, the non-radiative recombination of MoSe 2 is found shortened by almost one order of magnitude, from 160 ± 10 ps (on SiO 2 ) to 20 ± 4 ps (on HfO 2 ). Theoretical simulations based on ab initio non-adiabatic molecular dynamics (NAMD) method, together with temperature-dependent optical spectroscopy, identifies interfacial electron-phonon ( e-ph ) coupling as the leading mechanism for the lifetime tuning. Our results establish interface engineering as an effective knob for manipulating excited-state dynamics of monolayer TMDs.
    Type of Medium: Online Resource
    ISSN: 2399-3650
    URL: Article
    DOI: 10.1038/s42005-019-0202-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2921913-9
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  • 6
    Online Resource
    Online Resource
    Hydrogen Sulfide Ameliorates High-Glucose Toxicity in Rat Peritoneal Mesothelial Cells by Attenuating Oxidative Stress
    S. Karger AG ; 2014
    In:  Nephron Experimental Nephrology Vol. 126, No. 3 ( 2014-5-22), p. 157-165
    Details
    In: Nephron Experimental Nephrology, S. Karger AG, Vol. 126, No. 3 ( 2014-5-22), p. 157-165
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Continuous exposure of the peritoneal membrane to high-glucose (HG) peritoneal dialysis fluids (PDFs) can produce peritoneal mesothelial cells (PMCs) injury. It has been demonstrated that hydrogen sulfide (H 〈 sub 〉 2 〈 /sub 〉 S), the third endogenous gaseous mediator identified after nitric oxide and carbon monoxide, exhibits a potent protective effect on cell activity. We studied the toxic effects of HG PDFs and their reversal by H 〈 sub 〉 2 〈 /sub 〉 S on cultures of rat PMCs. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Synchronized confluent rat PMCs were incubated with 2.5% glucose PDFs with or without NaHS, an H 〈 sub 〉 2 〈 /sub 〉 S donor. Cell viability was assessed by methyl thiazolyl tetrazolium assay and flow cytometry. The level of phospho-p38 mitogen-activated protein kinase (MAPK) was analyzed by immunoblotting. p53, Bax and Bcl-2 mRNA expressions by rat PMCs were detected by real-time PCR. The levels of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and caspase-3 activity were measured. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Exposure of rat PMCs to 2.5% glucose PDFs for 24 h resulted in a significant induction of apoptosis, which was attenuated by NaHS. NaHS also restored the 2.5% glucose PDF-induced increase in phospho-p38 MAPK (indices of cellular toxicity). Further investigation of the apoptotic mechanisms in rat PMCs demonstrated that HG activated caspase-3 and upregulated Bax, while it downregulated Bcl-2. All the above responses were prevented by pretreatment with NaHS. Moreover, NaHS reversed the 2.5% glucose PDF-induced increase in ROS generation and decrease in SOD activity. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 These findings suggest that HG PDFs significantly inhibit rat PMC viability, leading to peritoneal injury. H 〈 sub 〉 2 〈 /sub 〉 S exhibits a potent anti-apoptotic ability by attenuating oxidative stress and inhibiting caspase-3 activation, which in turn restores peritoneal injury.
    Type of Medium: Online Resource
    ISSN: 1660-2129
    URL: Article
    DOI: 10.1159/000358436
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2098337-2
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  • 7
    Online Resource
    Online Resource
    Renal Replacement Therapy for Prevention of Contrast-Induced Acute Kidney Injury: A Meta-Analysis of Randomized Controlled Trials
    S. Karger AG ; 2010
    In:  American Journal of Nephrology Vol. 32, No. 5 ( 2010), p. 497-504
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 32, No. 5 ( 2010), p. 497-504
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Contrast-induced acute kidney injury (CI-AKI) is an important cause of acute renal injury. Several clinical trials using renal replacement therapy (RRT) for prevention of CI-AKI yielded conflicting results. We performed a meta-analysis to assess the efficacy of prophylactic RRT on CI-AKI. 〈 i 〉 Methods: 〈 /i 〉 Randomized controlled trials on CI-AKI using RRT were identified without language restriction in Cochrane library, Pubmed and Embase. Data extracted from literature were analyzed with Review manager and Stata software. 〈 i 〉 Results: 〈 /i 〉 Nine randomized controlled trials involving 751 patients were included. Heterogeneity was found across trials (p 〈 0.00001). A random effect model was used to combine the data. RRT reduced the risk of CI-AKI by 26% compared with the control group, but statistical significance was not reached (risk ratio (RR) 0.74, 95% CI 0.35–1.60, p = 0.45). Subgroup analysis of modality indicated that hemodialysis was ineffective in reducing the risk of CI-AKI (RR 1.21, 95% CI 0.63–2.32, p = 0.57), while CRRT decreased the incidence of CI-AKI (RR 0.22, 95% CI 0.07–0.64, p = 0.006). Subgroup analysis according to the CKD stage did not record heterogeneity across trials. RRT increased the odds of CI-AKI in CKD stage 3 patients (RR 1.53, 95% CI 0.07–0.64, p = 0.01), but decreased the occurrence of CI-AKI in patients with CKD stage higher than 3 (RR 0.74, 95% CI 0.35–1.60, p = 0.45). The pooled RR of the need for permanent dialysis demonstrated an insignificant trend towards benefit in patients treated with RRT (RR 0.61, 95% CI 0.26–1.40, p = 0.24). RRT reduced in-hospital mortality compared with control group (RR 0.33, 95% CI 0.14–0.77, p = 0.01). 〈 i 〉 Conclusion: 〈 /i 〉 RRT fails to reduce the incidence of CI-AKI in CKD stage 3 patients, but may be beneficial in patients with more advanced renal function. CRRT is more effective than hemodialysis for prevention of CI-AKI. RRT is effective in reducing the in-hospital mortality of CI-AKI patients.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000321344
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1468523-1
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  • 8
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    Online Resource
    Leriche syndrome masquerading as chronic kidney disease
    Dustri-Verlgag Dr. Karl Feistle ; 2014
    In:  Clinical Nephrology Vol. 82 (2014), No. 11 ( 2014-11-01), p. 337-340
    Details
    In: Clinical Nephrology, Dustri-Verlgag Dr. Karl Feistle, Vol. 82 (2014), No. 11 ( 2014-11-01), p. 337-340
    Type of Medium: Online Resource
    ISSN: 0301-0430
    URL: Article
    DOI: 10.5414/CN107900
    Language: English
    Publisher: Dustri-Verlgag Dr. Karl Feistle
    Publication Date: 2014
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  • 9
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    First-principles investigation of the effect of crystal structure on sulfur isotope fractionation in sulfide polymorphs
    Schweizerbart ; 2018
    In:  European Journal of Mineralogy Vol. 30, No. 6 ( 2018-12-20), p. 1047-1061
    Details
    In: European Journal of Mineralogy, Schweizerbart, Vol. 30, No. 6 ( 2018-12-20), p. 1047-1061
    Type of Medium: Online Resource
    ISSN: 0935-1221
    Uniform Title: First-principles investigation of the effect of crystal structure on sulfur isotope fractionation in sulfide polymorphs
    URL: Article
    DOI: 10.1127/ejm/2018/0030-2785
    RVK:
    TE 1000
    Language: English , English
    Publisher: Schweizerbart
    Publication Date: 2018
    detail.hit.zdb_id: 1000286-8
    detail.hit.zdb_id: 2039451-2
    SSG: 13
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  • 10
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    Promoting effect of nitration modification on activated carbon in the catalytic ozonation of oxalic acid
    Elsevier BV ; 2014
    In:  Applied Catalysis B: Environmental Vol. 146 ( 2014-03), p. 169-176
    Details
    In: Applied Catalysis B: Environmental, Elsevier BV, Vol. 146 ( 2014-03), p. 169-176
    Type of Medium: Online Resource
    ISSN: 0926-3373
    URL: Article
    DOI: 10.1016/j.apcatb.2013.05.006
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 2017331-3
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