In:
Journal of Orthopaedic Research, Wiley, Vol. 30, No. 5 ( 2012-05), p. 673-678
Abstract:
Histological and molecular changes were examined to investigate the effects of long‐term administration of glucosamine (GlcN) and chondroitin sulfate (CS) in a model of spontaneous osteoarthritis (OA) in Hartley guinea pigs. Three groups of female 3‐week‐old Hartley guinea pigs received GlcN, CS, and neither agent, respectively. Five animals in each group were sacrificed at 8, 12, and 18 months of age. At 8 months of age, Hartley guinea pigs had severe degeneration of knee joint cartilage, chondrocyte apoptosis, marked reduction of tissue total RNA, decreases of aggrecan and collagen type 2 mRNAs, and increases in MMP‐3 and MMP‐8 mRNAs. Long‐term administration of GlcN and CS reduced cartilage degeneration at 8 months of age. The marked loss of total RNA and the increase in MMP‐3 mRNA were also inhibited by GlcN and CS. Thus, long‐term oral administration of GlcN or CS inhibits OA progression, maintains total RNA and down‐regulates MMP‐3 mRNA in a spontaneous OA model in Hartley guinea pigs. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:673–678, 2012
Type of Medium:
Online Resource
ISSN:
0736-0266
,
1554-527X
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2050452-4
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