GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease
    MDPI AG ; 2020
    In:  Medicina Vol. 56, No. 2 ( 2020-02-03), p. 58-
    Details
    In: Medicina, MDPI AG, Vol. 56, No. 2 ( 2020-02-03), p. 58-
    Abstract: Background: It was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood. We hypothesized that the concentration of these lipids was correlated with the extent of their body mass reduction and, thus, liver steatosis. Methods: We analyzed 68 individuals who completed the dietary intervention. Patients were divided into two groups depending on their body mass reduction (more or less than 7%). Before and after the dietary intervention, all patients had the following measurements recorded: body mass, waist circumference, stage of steatosis, fatty liver index, liver enzymes, lipid parameters, insulin and glucose. Concentrations of lipoxins A4 (LTX A4), hydroxyeicosatetraenoic fatty acids (5(S)-HETE, 12(S)-HETE and 16(S)-HETE), hydroxyoctadecaenoic acids (9(S)-HODE and 13(S)-HODE) and 5-oxo-eicosatetraenoic acid (5-oxo-ETE) were measured in serum samples collected before and after the dietetic intervention using high-performance liquid chromatography (HPLC). Results: Patients who reduced their body mass by more than 7% revealed a significant improvement in their steatosis stage, waist circumference, fatty liver index, triglycerides and cholesterol. Conclusion: A reduction in body mass by more than 7% but not by less than 7% revealed a significant improvement in steatosis stage; waist circumference; fatty liver index; and levels of triglycerides, cholesterol, 5-oxo-ETE and LTXA-4.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina56020058
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2088820-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Abdominal Pain and Disturbed Bowel Movements are Frequent among Young People. A Population Based Study in Young Participants of the Woodstock Rock Festival in Poland
    Romanian Society of Gastroenterology and Hepatology ; 2018
    In:  Journal of Gastrointestinal and Liver Diseases Vol. 27, No. 4 ( 2018-12-31), p. 379-383
    Details
    In: Journal of Gastrointestinal and Liver Diseases, Romanian Society of Gastroenterology and Hepatology, Vol. 27, No. 4 ( 2018-12-31), p. 379-383
    Abstract: Background & Aims: Functional gastrointestinal disorders are prevalent worldwide and alterations of gutbrain axis and intestinal barrier integrity may play a pivotal role in both the pathophysiology and clinical course of these bowel malfunctions. We aimed to assess the prevalence of abdominal pain in a selected adult population of Poland to determine potential environmental factors associated with gastrointestinal complaints.Methods: There were 1479 individuals – 657 women (44.42%) and 822 men (55.58%), aged 24.20±6.08 years. The responders fulfilled an authors’ questionnaire based on Rome II and III criteria focused on the abdominal pain prevalence and environmental factors involved in its occurrence.Results: The frequency of abdominal pain was found to be as high as 19.2%. Male gender (n=822) and basic education level (n=151) lowered the risk of abdominal pain occurrence (OR=0.7, p 〈 0.012 and OR=0.5, p 〈 0.021, respectively). Psychological distress, proton pump inhibitors (PPIs) and antibiotics usage were found as risk factors of abdominal pain (OR=2.503, p 〈 0.01; OR=3.308, p 〈 0.01; OR=3.105, p 〈 0.01, respectively).Conclusions: Abdominal pain is prevalent in young adult inhabitants of Poland, especially in women. Intense psychological stress, as well as PPIs and antibiotics usage elevate the risk.
    Type of Medium: Online Resource
    ISSN: 1842-1121 , 1841-8724
    URL: Article
    DOI: 10.15403/jgld.2014.1121.274.pol
    Language: Unknown
    Publisher: Romanian Society of Gastroenterology and Hepatology
    Publication Date: 2018
    detail.hit.zdb_id: 2253255-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT)
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 20 ( 2022-10-15), p. 4310-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 20 ( 2022-10-15), p. 4310-
    Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is a wide spectrum condition characterized by excessive liver fat accumulation in people who do not abuse alcohol. There is no effective medical treatment for NAFLD; therefore, most important recommendations to reduce liver steatosis are diet and lifestyle, including proper physical activity. The aim of our study was to analyze the fatty acids and eicosanoids changes in the serum of patients who consumed high-fiber rolls for 8 weeks. Materials and Methods: The group of 28 Caucasian participants was randomly divided into two groups, those who received 24 g of fiber/day—from 2 buns of 12 g each (n = 14), and those who received 12 g of fiber/day—from 2 buns of 6 g (n = 14). At the beginning and on the last visit of the 8-week intervention, all patients underwent NAFLD evaluation, biochemical parameter measurements, and fatty acids and eicosanoids evaluation. Results: Patients who received 12 g of fiber had significantly reduced liver steatosis and body mass index. In the group who received 24 g of fiber/day, we observed a trend to liver steatosis reduction (p = 0.07) and significant decrease in aspartate aminotransferase (p = 0.03) and total cholesterol (p = 0.03). All changes in fatty acid and eicosanoids profile were similar. Fatty acids analysis revealed that extra fiber intake was associated with a significant increase in monounsaturated fatty acids and decrease in saturated fatty acids. Moreover, both groups showed increased concentration of gamma linoleic acid and docosahexaenoic acid. We also observed reduction in prostaglandin E2. Conclusions: Our study revealed that a high amount of fiber in the diet is associated with a reduction in fatty liver, although this effect was more pronounced in patients in the lower fiber group. However, regardless of the amount of fiber consumed, we observed significant changes in the profile of FAs, which may reflect the positive changes in the lipids liver metabolism. Regardless of the amount of fiber consumed, patients decreased the amount of PGE2, which may indicate the lack of disease progression associated with the development of inflammation.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14204310
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Has Menstruation Disappeared? Functional Hypothalamic Amenorrhea—What Is This Story about?
    MDPI AG ; 2021
    In:  Nutrients Vol. 13, No. 8 ( 2021-08-17), p. 2827-
    Details
    In: Nutrients, MDPI AG, Vol. 13, No. 8 ( 2021-08-17), p. 2827-
    Abstract: Functional hypothalamic amenorrhea (FHA) is a very common condition affecting women of procreative age. There are many reasons for this disorder, including a low availability of energy in the diet, low micro- and macronutrient intake, overly intensive physical activity, disturbed regeneration processes, sleep disorders, stress, and psychological disorders. The main determinant is long-term stress and an inability to handle the effects of that stress. FHA is a very complex disorder and often goes undiagnosed. Moreover, therapeutic interventions do not address all the causes of the disorder, which could have implications for women’s health. As shown by scientific reports, this condition can be reversed by modifying its causes. This review of the literature aims to update the current knowledge of functional hypothalamic amenorrhea and underscores the complexity of the disorder, with particular emphasis on the nutritional aspects and potential interventions for restoring balance.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu13082827
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2518386-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Reduction of sitting time has a positive effect on the decrease of insulin resistance in patients with non-alcoholic fatty liver disease
    Termedia Sp. z.o.o. ; 2016
    In:  Gastroenterology Review Vol. 4 ( 2016), p. 257-262
    Details
    In: Gastroenterology Review, Termedia Sp. z.o.o., Vol. 4 ( 2016), p. 257-262
    Type of Medium: Online Resource
    ISSN: 1895-5770
    URL: Article
    DOI: 10.5114/pg.2016.61355
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2016
    detail.hit.zdb_id: 2596134-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Identified in blood diet-related methylation changes stratify liver biopsies of NAFLD patients according to fibrosis grade
    Springer Science and Business Media LLC ; 2022
    In:  Clinical Epigenetics Vol. 14, No. 1 ( 2022-12)
    Details
    In: Clinical Epigenetics, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2022-12)
    Abstract: High caloric diet and lack of physical activity are considered main causes of NAFLD, and a change in the diet is still the only effective treatment of this disease. However, molecular mechanism of the effectiveness of diet change in treatment of NAFLD is poorly understood. We aimed to assess the involvement of epigenetic mechanisms of gene expression regulation in treatment of NAFLD. Eighteen participants with medium- to high-grade steatosis were recruited and trained to follow the Mediterranean diet modified to include fibre supplements. At three timepoints (baseline, after 30 and 60 days), we evaluated adherence to the diet and measured a number of physiological parameters such as anthropometry, blood and stool biochemistry, liver steatosis and stiffness. We also collected whole blood samples for genome-wide methylation profiling and histone acetylation assessment. Results The diet change resulted in a decrease in liver steatosis along with statistically significant, but a minor change in BMI and weight of our study participants. The epigenetic profiling of blood cells identified significant genome-wide changes of methylation and acetylation with the former not involving regions directly regulating gene expression. Most importantly, we were able to show that identified blood methylation changes occur also in liver cells of NAFLD patients and the machine learning-based classifier that we build on those methylation changes was able to predict the stage of liver fibrosis with ROC AUC = 0.9834. Conclusion Methylomes of blood cells from NAFLD patients display a number of changes that are most likely a consequence of unhealthy diet, and the diet change appears to reverse those epigenetic changes. Moreover, the methylation status at CpG sites undergoing diet-related methylation change in blood cells stratifies liver biopsies from NAFLD patients according to fibrosis grade.
    Type of Medium: Online Resource
    ISSN: 1868-7075 , 1868-7083
    URL: Article
    DOI: 10.1186/s13148-022-01377-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2553921-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Suplementacja wśród mężczyzn amatorsko uprawiających kulturystkę
    Poznan University of Medical Sciences ; 2020
    In:  Polski Przegląd Nauk o Zdrowiu Vol. 61, No. 4 ( 2020-05-19), p. 280-287
    Details
    In: Polski Przegląd Nauk o Zdrowiu, Poznan University of Medical Sciences, Vol. 61, No. 4 ( 2020-05-19), p. 280-287
    Type of Medium: Online Resource
    ISSN: 1643-3203 , 2544-283X
    URL: Journal
    URL: Article
    DOI: 10.20883/issn.1643-3203
    DOI: 10.20883/ppnoz.2019.60
    Language: Unknown
    Publisher: Poznan University of Medical Sciences
    Publication Date: 2020
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    ZMIANY MASY CIAŁA I STĘŻENIA LIPIDÓW PACJENTÓW PODDANYCH RESTRYKCJOM KALORYCZNYM – DONIESIENIE WSTĘPNE
    Pomorski Uniwersytet Medyczny w Szczecinie ; 2016
    In:  Pomeranian Journal of Life Sciences Vol. 60, No. 2 ( 2016-07-20)
    Details
    In: Pomeranian Journal of Life Sciences, Pomorski Uniwersytet Medyczny w Szczecinie, Vol. 60, No. 2 ( 2016-07-20)
    Abstract: Introduction: Caloric restriction is the only well‍‑documented nutritional intervention prolonging the life of mammals. This method modifies the lipid levels in blood, controlling obesity and delaying the onset of many medical conditions associated with metabolic disorders. The aim of the study was to carry out a comparative analysis of lipid profile in patients on Mediterranean or CRON (Caloric Restriction with Optimal Nutrition) diets, before and after six weeks of dieting.Material and methods: The following parameters were compared: total cholesterol, total lipids, triglycerides, LDL cholesterol, HDL cholesterol, and BMI. Additionally, we measured the levels of insulin, HOMA score, and anthropometric parameters. The comparative analysis demonstrated a statistically significant correlation between mild caloric restriction and blood lipid profile.Results from studies on patients who underwent six­‍‑week dietetic intervention indicated statistically significant changes in biochemical parameters due to caloric restrictions. Such changes were not found in subjects following the Mediterranean diet. The greatest decrease in the blood level of triglycerides was found in subjects on the CRON diet, LDL cholesterol, total cholesterol and total lipid levels also decreased. No significant changes if biochemical parameters were found in patients on the Mediterranean diet.Conclusions: A comparative analysis of all parameters demonstrated that the use of mild caloric restrictions with ensured supply of all necessary nutrients seems to be the most effective solution for reducing fatty tissue.
    Type of Medium: Online Resource
    ISSN: 2450-4637
    URL: Article
    DOI: 10.21164/pomjlifesci.27
    Language: Unknown
    Publisher: Pomorski Uniwersytet Medyczny w Szczecinie
    Publication Date: 2016
    detail.hit.zdb_id: 2856105-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Metabolic risk factors of coronary heart disease in relation to anthropometric measures in nonalcoholic fatty liver disease patients following dietary intervention
    Pomorski Uniwersytet Medyczny w Szczecinie ; 2016
    In:  Pomeranian Journal of Life Sciences Vol. 62, No. 2 ( 2016-12-08)
    Details
    In: Pomeranian Journal of Life Sciences, Pomorski Uniwersytet Medyczny w Szczecinie, Vol. 62, No. 2 ( 2016-12-08)
    Abstract: Wstęp:Niealkoholowa stłuszczeniowa choroba wątroby (NAFLD) jest związana z wysokim ryzykiem zaburzeń metabolicznych (zespół metaboliczny, cukrzyca typu 2) oraz choroby wieńcowej.Materiały i metody: Grupę badaną stanowiło 108 osób dorosłych rasy kaukaskiej (39 kobiet i 69 mężczyzn) w wieku 20–77 lat z rozpoznaną NAFLD. Podstawą diagnozy było dokładne badanie USG wątroby oraz analiza parametrów wątrobowych: aminotransferazy alaninowej i aminotransferazy asparaginianowej w surowicy. Wszystkie badania przeprowadzono podczas pierwszej i ostatniej wizyty pacjentów w placówce badawczej (po 6 miesiącach od interwencji dietetycznej). Dokonywano także pomiarów antropometrycznych (wskaźnik masy ciała – BMI, obwód pasa – WC, wskaźnik talia–biodra – WHR, wskaź- nik talia–wzrost – WHtR, wskaźnik stożkowatości – C -Index) w odniesieniu do metabolicznych czynników ryzyka choroby niedokrwiennej serca (podwyższone stężenie w surowicy: triacylogliceroli, cholesterolu lipoprotein niskiej gęstości, cholesterolu całkowitego, glukozy oraz obniżone stężenie cholesterolu lipoprotein wysokiej gęstości).Wyniki: Zarówno w grupie kobiet, jak i mężczyzn wykazano istotną statystycznie redukcję wartości parametrów takich jak: masa ciała, BMI, WC, WHR, WHtR i C -Index (p 〈 0,05), co miało wpływ na poprawę stężenia triacylogliceroli w surowicy u obu płci (p 〈 0,05). Wskaźniki identyϐikujące otyłość brzuszną (WC, WHR, WHtR, C -Index) korelowały istotnie z wartością glikemii (p 〈 0,05) zarówno przed interwencją dietetyczną, jak i po niej oraz ze stężeniem lipidów w surowicy przed interwencją lub po (p 〈 0,05) u obu płci.Wnioski: Rozpowszechnienie użycia prostych narzędzi antropometrycznych (przede wszystkim C -Index i WHtR) wydaje się być korzystne, zwłaszcza na szczeblu podstawowej opieki zdrowotnej. Narzędzia te mogą służyć zarówno do prewencji, jak i wczesnego wykrywania metabolicznych czynników ryzyka choroby niedokrwiennej serca, a co za tym idzie potencjalnie śmiertelnych konsekwencji incydentów wieńcowych u pacjentów z NAFLD lub z innymi zaburzeniami metabolizmu.
    Type of Medium: Online Resource
    ISSN: 2450-4637
    URL: Article
    DOI: 10.21164/pomjlifesci.141
    Language: Unknown
    Publisher: Pomorski Uniwersytet Medyczny w Szczecinie
    Publication Date: 2016
    detail.hit.zdb_id: 2856105-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Fruit and vegetable consumption among the young Polish population
    Pomorski Uniwersytet Medyczny w Szczecinie ; 2017
    In:  Pomeranian Journal of Life Sciences Vol. 62, No. 3 ( 2017-05-26)
    Details
    In: Pomeranian Journal of Life Sciences, Pomorski Uniwersytet Medyczny w Szczecinie, Vol. 62, No. 3 ( 2017-05-26)
    Abstract: Introduction: Vegetables and fruit are an essential part of a healthy and balanced diet. It has been shown that regular consumption of fruit and vegetables can reduce the risk of chronic diseases. However, in the past ͜8 years fruit and vegetable consumption among Polish youth has significantly decreased.Materials and methods: Patients involved in the project were participants of the Woodstock Festival Poland 2014 During three days of the festival, 615 young adults (18–35 years) were enrolled in the study. The study participants had to fill in a questionnaire that included questions about the frequency of fruit and vegetable consumption, portion sizes, and knowledge of the recommended daily intake. We also measured basic anthropometric parameters.Results: The data from our study showed that 97,6% of respondents consumed fewer than ͘ servings of vegetables and fruit. In addition 39% of them ate 2 or fewer vegetable servings per day. We found that men ate significantly less fruit and fewer vegetables than women (p 〈 0.05). Additionally, almost 75 % of men responded that proper consumption of fruit and vegetables should be at the level of 4–5 servings, and only 22,3% of them said that the proper level is ͘4–5servings.Conclusions: We need to keep in mind that only clear information about vegetables and fruit, as well as highlighting the importance of the principles of nutrition, can give effective results in the future. It also appears that nutritional education should be conducted not only at the early stages of development but also in adolescents.
    Type of Medium: Online Resource
    ISSN: 2450-4637
    URL: Article
    DOI: 10.21164/pomjlifesci.184
    Language: Unknown
    Publisher: Pomorski Uniwersytet Medyczny w Szczecinie
    Publication Date: 2017
    detail.hit.zdb_id: 2856105-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...