In:
Cell Transplantation, SAGE Publications, Vol. 3, No. 2 ( 1994-03), p. 187-192
Abstract:
Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.
Type of Medium:
Online Resource
ISSN:
0963-6897
,
1555-3892
DOI:
10.1177/096368979400300207
Language:
English
Publisher:
SAGE Publications
Publication Date:
1994
detail.hit.zdb_id:
2020466-8
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