In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 7 ( 2021-7-30), p. e0009641-
Abstract:
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009641
DOI:
10.1371/journal.pntd.0009641.g001
DOI:
10.1371/journal.pntd.0009641.g002
DOI:
10.1371/journal.pntd.0009641.g003
DOI:
10.1371/journal.pntd.0009641.g004
DOI:
10.1371/journal.pntd.0009641.g005
DOI:
10.1371/journal.pntd.0009641.g006
DOI:
10.1371/journal.pntd.0009641.t001
DOI:
10.1371/journal.pntd.0009641.s001
DOI:
10.1371/journal.pntd.0009641.s002
DOI:
10.1371/journal.pntd.0009641.s003
DOI:
10.1371/journal.pntd.0009641.s004
DOI:
10.1371/journal.pntd.0009641.s005
DOI:
10.1371/journal.pntd.0009641.s006
DOI:
10.1371/journal.pntd.0009641.r001
DOI:
10.1371/journal.pntd.0009641.r002
DOI:
10.1371/journal.pntd.0009641.r003
DOI:
10.1371/journal.pntd.0009641.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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