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  • 1
    Online Resource
    Online Resource
    Pendampingan dan Optimalisasi Kompetensi Guru dalam Penulisan Artikel Ilmiah melalui Web Seminar pada masa pandemi COVID-19 di Papua Barat
    Universitas Muhammadiyah Magelang ; 2020
    In:  Community Empowerment Vol. 5, No. 2 ( 2020-10-30), p. 64-72
    Details
    In: Community Empowerment, Universitas Muhammadiyah Magelang, Vol. 5, No. 2 ( 2020-10-30), p. 64-72
    Abstract: Pengabdian masyarakat ini bertujuan untuk meningkatkan kompetensi menulis artikel ilmiah melalui webinar pada guru di Papua Barat. Metode dampingan menggunakan Participatory Action Research (PAR). Peserta dampingan sebanyak 35 orang dari Kota dan Kabupaten Sorong. Digunakan empat tahapan dalam melakukan pendampingan yaitu, tahap perencanaan, tindakan, observasi, dan refleksi. Hasil pendampingan menunjukkan bahwa kompetensi guru dalam menulis artikel ilmiah mengalami peningkatan. Pada kondisi awal, guru memiliki kompetensi kurang baik (59,7) dan berhasil ditingkatkan menjadi baik (72,6). Dari pelaksanaannya, kegiatan webinar direspons positif dan sangat dibutuhkan guru (84,2) dalam upaya peningkatan kompetensi menulis artikel ilmiah. Kesimpulannya, pendampingan menggunakan webinar dapat menjadi pilihan dalam meningkatkan kompetensi guru di Papua Barat saat pandemi Covid-19.
    Type of Medium: Online Resource
    ISSN: 2621-4024 , 2614-4964
    URL: Issue
    URL: Article
    DOI: 10.31603/ce.v5i2
    DOI: 10.31603/ce.v5i2.4021
    Language: Unknown
    Publisher: Universitas Muhammadiyah Magelang
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    The Potential Cytotoxic Activity Enhancement of α-Mangostin in Chitosan-Kappa Carrageenan-Loaded Nanoparticle against MCF-7 Cell Line
    MDPI AG ; 2021
    In:  Polymers Vol. 13, No. 11 ( 2021-05-21), p. 1681-
    Details
    In: Polymers, MDPI AG, Vol. 13, No. 11 ( 2021-05-21), p. 1681-
    Abstract: α-mangostin (αM), a xanthone derivative compound isolated from the extract of mangosteen pericarp (Garcinia mangostana L), has potential anticancer properties for breast cancer. However, it has poor solubility in water and low selectivity towards cancer cells. The polymeric nanoparticle formulation approach can be used to overcome these problems. In this study, a chitosan biopolymer-based αM polymeric nanoparticle formulation was encapsulated using kappa carrageenan (αM-Ch/Cr) as a novel carrier for breast cancer therapy and evaluated for their physicochemical properties, drug release profile, and in vitro cytotoxicity against breast cancer cells (MCF-7). Polymeric nanoparticles formulated with varying concentrations of kappa carrageenan were successfully prepared by ionic gelation and spray pyrolysis techniques. αM-Ch/Cr nanoparticles formed perfectly round particles with a size of 200–400 nm and entrapment efficiency ≥ 98%. In vitro release studies confirmed that αM-Ch/Cr nanoparticles had a sustained release system profile. Interestingly, the formulation of polymeric nanoparticles significantly (p 〈 0.05) increased the cytotoxicity of αM against MCF-7 cell with IC50 value of 4.7 μg/mL compared to the non-nanoparticle with IC50 of 8.2 μg/mL. These results indicate that αM-Ch/Cr nanoparticles have the potential to improve the physicochemical properties and cytotoxicity effects of αM compounds as breast cancer therapy agents.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym13111681
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2527146-5
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  • 3
    Online Resource
    Online Resource
    Ring Road Development Problems in Metropolitan Cities of Indonesia
    EDP Sciences ; 2020
    In:  MATEC Web of Conferences Vol. 331 ( 2020), p. 07001-
    Details
    In: MATEC Web of Conferences, EDP Sciences, Vol. 331 ( 2020), p. 07001-
    Abstract: The development of ring roads in Indonesia are not only as a means of transportation needs but also as a means for the urban regional development. Although it produces many economic benefits, this development produces many new problems, especially in metropolitan cities. The aim of this research is to formulate and describe the problems of ring road development in the metropolitan cities of Indonesia. The data collection was carried out through a survey and interview with related institutions in 7 cities, they are Medan, Palembang, Bandar Lampung, Surabaya, Makassar, Manado, and Jakarta. The result of this research shows that there are 23 problems found there. The most common problem found are the uncontrolled housing development (urban sprawl) and public transportation (occurs in 6 cities). The second most problems found are regional connectivity, ring road intersection, housing access, settlement facilities, and social problems (occurs in 5 cities). All the existing problems can be classified into 6 problem types, they are (1) problem of ring road preparation and construction, (2) problem of disobedience and inconsistency of regulation, (3) problem of spatial planning and urban development, (4) problem of housing growth and facilities provision, (5) problem of coordination among institution and regulatory synchronization, and (6) problem of environmental management related to the integration of ring road and settlement development.
    Type of Medium: Online Resource
    ISSN: 2261-236X
    URL: Article
    DOI: 10.1051/matecconf/202033107001
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 2673602-0
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  • 4
    Online Resource
    Online Resource
    MOLECULAR DOCKING STUDY OF THE MAJOR COMPOUNDS FROM GARCINIA ATROVIRIDIS ON HUMAN SGLT-2 PROTEIN TRANSPORT USING STRUCTURE-BASED DRUG DESIGN METHOD
    Innovare Academic Sciences Pvt Ltd ; 2022
    In:  International Journal of Applied Pharmaceutics ( 2022-07-07), p. 138-143
    Details
    In: International Journal of Applied Pharmaceutics, Innovare Academic Sciences Pvt Ltd, ( 2022-07-07), p. 138-143
    Abstract: Objective: The objective of this work was to study the molecular interactions of phytochemicals in Garcinia atroviridis with SGLT-2 protein transport. Methods: Molecular docking simulation using Autodock 4.2 was performed to explore the binding affinity of phytochemicals in Garcinia atroviridis against SGLT-2 protein transport. The structure-based pharmacophore model was derived using LigandScout 4.4 Advanced to investigate the important chemical interactions of the ligands and protein target. The evaluation was conducted based on the free energy binding and visualization in silico. Results: From this study, Myricetin is the most effective compound having similarity of interaction with the amino acid residue, 4 of 5 are hydrogen bond interactions between the amino acid; HIS80, ASN75, TRP291, and LYS321 amino acid interacted with the oxygen as the proton acceptor from benzenes of the Myricetin structure, in addition, Myricetin also has the lower binding energy and inhibition constant (-9.54 kcal/mol and 101.93 nM, respectively) as compared to other compounds. Conclusion: Hence, Myricetin could become the potential compound as an antidiabetic agent in the future with good activity and lower side effects.
    Type of Medium: Online Resource
    ISSN: 0975-7058
    URL: Article
    DOI: 10.22159/ijap.2022v14i4.44390
    Language: Unknown
    Publisher: Innovare Academic Sciences Pvt Ltd
    Publication Date: 2022
    detail.hit.zdb_id: 2675577-4
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Inhibition of Crystal Nucleation and Growth in Aqueous Drug Solutions: Impact of Different Polymers on the Supersaturation Profiles of Amorphous Drugs—The Case of Alpha-Mangostin
    MDPI AG ; 2022
    In:  Pharmaceutics Vol. 14, No. 11 ( 2022-11-05), p. 2386-
    Details
    In: Pharmaceutics, MDPI AG, Vol. 14, No. 11 ( 2022-11-05), p. 2386-
    Abstract: The polymer used in supersaturated solutions plays a critical role in maintaining supersaturation levels of amorphous drugs. The prevention of drug crystallization in the supersaturated solutions by adding polymers depends on their ability to inhibit nucleation and crystal growth of drugs. This showed that understanding the mechanism of nucleation inhibition by polymers is necessary to develop the drug formulation in supersaturated solutions. Therefore, this study aims to evaluate the impact of water-soluble polymers on the supersaturation behavior of drugs and elucidate the mechanism of maintaining the supersaturation levels in an aqueous solution. It was carried out using alpha-mangostin (AM) as a model of the poorly water-soluble drug, while hypromellose (HPMC), polyvinylpyrrolidone (PVP), and eudragit were used as polymers. Their ability to inhibit the nucleation and crystal growth of AM was also evaluated. The supersaturation profiles of AM were measured in biorelevant dissolution media, while the crystal growth rate of AM was evaluated from the decrease in dissolved drug concentration by determining the induction time for AM nucleation. The interaction of AM with each polymer was evaluated and predicted by FT-IR, NMR measurement, and an in silico study, respectively. Based on observation, the PVP effectively maintained AM in a supersaturated state for the long term while eudragit conserved for 15 min. Meanwhile, an inhibitory effect of HPMC on the AM crystal nucleation was not observed. It was also discovered that the effectiveness of the various polymers depends on the interaction between the polymer and the drug. FT-IR and in silico studies demonstrated that the interaction of PVP-AM had the best polymer compared to eudragit and HPMC. NMR analysis suggested that the interaction between the methyl group from PVP with the carbonyl group of AM occurred in the PVP solution. The viscosity measurement revealed that the inhibition of nucleation and crystal growth of AM was not caused by increasing the viscosity. These results indicated that polymer–AM interactions could contribute to the crystallization inhibition and maintenance of AM in a supersaturated state. Therefore, an investigation of the mechanism of drug nucleation inhibition by polymers is recommended in the selection of crystallization inhibitors and a planned strategy to develop supersaturated formulations of drugs.
    Type of Medium: Online Resource
    ISSN: 1999-4923
    URL: Article
    DOI: 10.3390/pharmaceutics14112386
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527217-2
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    〈p〉Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System〈/p〉
    Informa UK Limited ; 2020
    In:  Drug Design, Development and Therapy Vol. Volume 14 ( 2020-10), p. 4387-4405
    Details
    In: Drug Design, Development and Therapy, Informa UK Limited, Vol. Volume 14 ( 2020-10), p. 4387-4405
    Type of Medium: Online Resource
    ISSN: 1177-8881
    URL: Article
    DOI: 10.2147/DDDT.S273612
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2451346-5
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    〈p〉Nanoparticle Drug Delivery Systems for α-Mangostin〈/p〉
    Informa UK Limited ; 2020
    In:  Nanotechnology, Science and Applications Vol. Volume 13 ( 2020-04), p. 23-36
    Details
    In: Nanotechnology, Science and Applications, Informa UK Limited, Vol. Volume 13 ( 2020-04), p. 23-36
    Type of Medium: Online Resource
    ISSN: 1177-8903
    URL: Article
    DOI: 10.2147/NSA.S243017
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2494782-9
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  • 8
    Online Resource
    Online Resource
    Current Techniques of Water Solubility Improvement for Antioxidant Compounds and Their Correlation with Its Activity: Molecular Pharmaceutics
    MDPI AG ; 2023
    In:  Antioxidants Vol. 12, No. 2 ( 2023-02-04), p. 378-
    Details
    In: Antioxidants, MDPI AG, Vol. 12, No. 2 ( 2023-02-04), p. 378-
    Abstract: The aqueous solubility of a drug is important in the oral formulation because the drug can be absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its bioavailability. Almost 80% of active pharmaceutical ingredients are poorly water-soluble, including antioxidant compounds. This makes antioxidant activity inefficient in preventing disease, particularly for orally administered formulations. Although several investigations have been carried out to improve the solubility of antioxidant compounds, there is still limited research fully discussing the subject. Therefore, this study aimed to provide an overview and discussion of the issues related to the methods that have been used to improve the solubility and activity of antioxidant compounds. Articles were found using the keywords “antioxidant” and “water solubility improvement” in the Scopus, PubMed, and Google Scholar databases. The selected articles were published within the last five years to ensure all information was up-to-date with the same objectives. The most popular methods of the strategies employed were solid dispersion, co-amorphous, and nanoparticle drug delivery systems, which were used to enhance the solubility of antioxidant compounds. These investigations produced impressive results, with a detailed discussion of the mechanism of improvement in the solubility and antioxidant activity of the compounds developed. This review shows that the strategies used to increase the solubility of antioxidant compounds successfully improved their antioxidant activity with enhanced free radical scavenging abilities.
    Type of Medium: Online Resource
    ISSN: 2076-3921
    URL: Article
    DOI: 10.3390/antiox12020378
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704216-9
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Elastic Foundation Beam Analysis on Rigid Pavement and Piles
    EDP Sciences ; 2020
    In:  MATEC Web of Conferences Vol. 331 ( 2020), p. 05005-
    Details
    In: MATEC Web of Conferences, EDP Sciences, Vol. 331 ( 2020), p. 05005-
    Abstract: In this study, the rigid pavement structure and pile foundation were modeled as the foundation of the Winkler elastic beam. for pavement with distribution loads and traffic loads, and variations in support. While for pile foundations with lateral loads. Solution of analytical differential equations with computer applications (CAS) Maple. The aim of this research are : (a). To know whether completion of algebraic computer application can be obtained by analytically method or numerically method, (b). To check whether analytical model is possible to be applied to various loads at any point in the beam or not, (c). Where of the strength or the displacement boundary to be located in the beam during load application, (d). To verify an approach possibility implementation of a simple computer algebra system, (e). To know whether achieved solutions which possible to solve ordinary differential equation (ODE) can be implemented in any mathematical system.
    Type of Medium: Online Resource
    ISSN: 2261-236X
    URL: Article
    DOI: 10.1051/matecconf/202033105005
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 2673602-0
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  • 10
    Online Resource
    Online Resource
    3D-PHARMACOPHORE MODELLING OF OMEGA-3 DERIVATIVES WITH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AS AN ANTI-OBESITY AGENT
    Innovare Academic Sciences Pvt Ltd ; 2021
    In:  International Journal of Applied Pharmaceutics ( 2021-12-11), p. 167-170
    Details
    In: International Journal of Applied Pharmaceutics, Innovare Academic Sciences Pvt Ltd, ( 2021-12-11), p. 167-170
    Abstract: Objective: The aim of this work was to study the pharmacophore model of omega-3 derivatives with the PPAR-γ receptor using LigandScout 4.4.3 to investigate the important chemical interactions of complex structure. Methods: The methods consisted of structure preparation of nine chemical compounds derived from omega-3 fatty acids, database preparation, creating 3D Pharmacophore modelling, validation pharmacophore, and screening test compounds. Results: The result of the research showed that the omega-3 derivatives docosahexaenoic acid (DHA), when eicosapentaenoic acid (HPA), and docosapentaenoic acid (DPA) have the best pharmacophore fit values of 36.59; 36.56; and 36.56, respectively. According to the results of the pharmacophore study, the carbonyl and hydroxyl of the carboxylate functional groups become the active functional groups that exhibit hydrogen bonding interactions. While the alkyl chain (Ethyl and methyl groups) was the portion that can be modified to increase its activity. Conclusion: Omega-3 derivatives could be used as a lead drug for the powerful PPAR-γ receptor in the prevention and treatment of obesity.
    Type of Medium: Online Resource
    ISSN: 0975-7058
    URL: Article
    DOI: 10.22159/ijap.2021.v13s4.43851
    Language: Unknown
    Publisher: Innovare Academic Sciences Pvt Ltd
    Publication Date: 2021
    detail.hit.zdb_id: 2675577-4
    SSG: 15,3
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