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  • 1
    Online Resource
    Online Resource
    Gold nanoparticles functionalized with a fragment of the neural cell adhesion molecule L1 stimulate L1-mediated functions
    Royal Society of Chemistry (RSC) ; 2013
    In:  Nanoscale Vol. 5, No. 21 ( 2013), p. 10605-
    Details
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 5, No. 21 ( 2013), p. 10605-
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    URL: Article
    DOI: 10.1039/c3nr02707d
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2013
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  • 2
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    Inactivation of macrophage nitric oxide synthase activity by NG-Methyl-L-arginine
    Elsevier BV ; 1991
    In:  Biochemical and Biophysical Research Communications Vol. 177, No. 2 ( 1991-06), p. 828-833
    Details
    In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 177, No. 2 ( 1991-06), p. 828-833
    Type of Medium: Online Resource
    ISSN: 0006-291X
    URL: Article
    DOI: 10.1016/0006-291X(91)91864-9
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1991
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  • 3
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    Granulomatous encephalitis: protothecosis excluded?
    Wiley ; 2016
    In:  Histopathology Vol. 69, No. 6 ( 2016-12), p. 1082-1084
    Details
    In: Histopathology, Wiley, Vol. 69, No. 6 ( 2016-12), p. 1082-1084
    Type of Medium: Online Resource
    ISSN: 0309-0167 , 1365-2559
    URL: Issue
    URL: Article
    DOI: 10.1111/his.2016.69.issue-6
    DOI: 10.1111/his.13020
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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    detail.hit.zdb_id: 131914-0
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  • 4
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    PSV-13 Evaluation of Hydrafit Pre-Slaughter on Finishing Beef Steer: Dressing Percentage, Hot Carcass Weight, and Cold Carcass Weight
    Oxford University Press (OUP) ; 2023
    In:  Journal of Animal Science Vol. 101, No. Supplement_2 ( 2023-10-28), p. 338-338
    Details
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 101, No. Supplement_2 ( 2023-10-28), p. 338-338
    Abstract: The objective of this experiment was to determine if electrolyte application (glycerol-based electrolyte solution containing potassium chloride, acetic acid, magnesium hydroxide, sodium propionate, and sodium chloride; 5.10% potassium, 1.00% sodium, and 0.87% magnesium; HydraFit—Micronutrients USA LLC, Indianapolis IN) before shipping for harvest increased cold carcass weight in beef steers. Steers (n = 40; 20 steers per treatment; BW = 659 ± 72.9 kg) were weighed 40 h before harvest, blocked by BW (n = 4 BW blocks), and assigned to one of two treatments: no HydraFit (Con) or HydraFit (HF) added to the water at 4% vol/vol (4 pens/treatment, 8 pens total). Feed and water access was not restricted nor was a shrink percentage applied to any BW measures. Thirty-six hours before harvest a 378 L water tank was filled with water from the same source the steers had been consuming since arrival. Water and feed were introduced at 36 h before harvest. Final BW was captured immediately before shipping (12 h prior to harvest). Cattle were transported 98 km to a commercial abattoir. Cattle were held in lairage with ad libitum access to water before harvest the following morning. Water intake pre-shipment was determined after the cattle were removed from the pens and transported to slaughter. Water volume was estimated by measuring water depth remaining in the tank. Depth measurements were calibrated to water volume by metering (DM-P; Assured Automation, Roselle, NJ; ± 1.0%) 0.64 cm of water into each tank and recording the liters of water metered. Hot carcass weight was determined at the time of slaughter and cold carcass data was determined after a 48-hour chill. One steer from Con was condemned at the abattoir for reasons unrelated to treatment, consequently, the contribution of this steer to the pen mean was deleted. Providing HF in the drinking water for approximately 22 hours before shipping for harvest tended to increase final body weight (P = 0.08) by 1% but had no effect (P ≥ 0.88) on hot or cold carcass weight. In conclusion, providing a glycerol-based electrolyte solution to finished beef cattle for approximately 22 hours before shipping for harvest tended to improve final body weight.
    Type of Medium: Online Resource
    ISSN: 0021-8812 , 1525-3163
    URL: Article
    DOI: 10.1093/jas/skad341.384
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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  • 5
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    Effect of Lighter and Heavier Initial Weight on Growth Performance and Carcass Traits of Single-Source Beef Steers
    MDPI AG ; 2024
    In:  Animals Vol. 14, No. 4 ( 2024-02-08), p. 567-
    Details
    In: Animals, MDPI AG, Vol. 14, No. 4 ( 2024-02-08), p. 567-
    Abstract: The objective of the study was to determine the influence that initial BW has on growth performance responses, efficiency of dietary net energy (NE) utilization, and carcass traits in feedlot steers. Charolais×Red Angus steers (n = 70) selected from a larger single-source group were used in a 209-d growing-finishing feedlot experiment. Steers were assigned to two groups based on initial BW (light initial weight, LIW = 273 ± 16.0 kg; heavy initial weight, HIW = 356 ± 14.2 kg) and allotted into 10 pens (n = 7 steers per pen; 5 pens per experimental group) the within pen standard deviation for LIW was from 14.1 kg to 20.9 kg and for HIW was from 13.7 kg to 16.0 kg. Steers were fed a common diet once daily. Experimental data were analyzed as a randomized complete block design with pen as the experimental unit. LIW steers had a greater cumulative HH change (p = 0.04). A treatment × day interaction (p = 0.05) was observed for HH with HIW steers having a greater HH at all time points. Final BW and carcass-adjusted (HCW/0.625) BW were greater for HIW steers by 13.1% and 13.4% respectively (p ≤ 0.01). HIW steers had a greater DMI (p = 0.01) compared to LIW. Cumulative ADG was greater for HIW by 3% (p = 0.04). LIW steers had better feed conversion (p = 0.01). HIW steers had greater (p ≤ 0.05) HCW, marbling scores, and yield grade (YG), with decreased REA/HCW (p = 0.01) compared to LIW. The distribution of USDA Yield Grade was altered by initial BW (p = 0.04). No differences were detected (p ≥ 0.22) for the distribution of Quality grade nor liver abscess prevalence and severity. Regression coefficients did not differ between LIW and HIW for urea space calculations of empty body water, fat, or protein (p ≥ 0.70). A quadratic response was noted for empty body fat (EBF), empty body water (EBH20), and carcass protein (CP). In conclusion, HIW steers had greater growth, but poorer feed efficiency compared to LIW steers. Steers with a HIW produced fatter carcasses with a greater degree of marbling.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani14040567
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
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  • 6
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    Evaluation of Growth Performance, Efficiency of Dietary Net Energy Utilization, and Carcass Trait Responses of Heavy Finishing Lambs Administered 12 mg of Zeranol Subcutaneously in the Ear 59 d before Harvest
    MDPI AG ; 2023
    In:  Ruminants Vol. 3, No. 3 ( 2023-09-07), p. 240-245
    Details
    In: Ruminants, MDPI AG, Vol. 3, No. 3 ( 2023-09-07), p. 240-245
    Abstract: The objective of this research was to determine the influence of implanting heavy wether lambs with 12 mg of zeranol (1 pellet Ralgro, Merck Animal Health. Madison, NJ, USA) 59 d before harvest. Average daily gain (ADG), feed efficiency, and carcass merit were evaluated. Polypay and crossbred wethers (n = 32) were equally divided into two treatment groups: non-implanted; (CON) or implanted with 12 mg of zeranol (IMP) in a randomized complete block design. Sixteen pens were used, resulting in eight replicate pens per treatment. Wethers were fed a finishing diet consisting of cracked corn, soybean meal, and soybean hulls ad libitum for 59 d. Lambs had access to clean water at all times from water fountains. Lambs were weighed on d -1, 1, 14, and 59. On d 59, 16 lambs (8 lambs/treatment) were harvested in the South Dakota State University Meat Lab. Hot carcass weight (HCW), dressing percent (DP), rib fat, body wall thickness, loin eye area, boneless closely trimmed retail cut percentages, and yield grades were recorded. Final body weight (BW), cumulative ADG, and gain efficiency were greater (p ≤ 0.01) for implanted lambs by 2.9%, 25.0%, and 35.2%, respectively, while dry matter intake (DMI) was unaffected by implant treatment (p = 0.18); thus, the efficiency of dietary net energy utilization was increased for IMP (p ≤ 0.01). No appreciable differences were noted (p ≥ 0.17) between treatments for any carcass traits measured. These results indicate that zeranol improves growth performance in heavy finishing lambs without detriment to carcass quality, which implies that producers can improve profitability due to increased gains and efficiency.
    Type of Medium: Online Resource
    ISSN: 2673-933X
    URL: Article
    DOI: 10.3390/ruminants3030022
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
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  • 7
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    Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Stroke Vol. 53, No. 12 ( 2022-12), p. 3557-3563
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 53, No. 12 ( 2022-12), p. 3557-3563
    Abstract: The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely influence individual IVT treatment decisions. Using data from a large IVT registry, we aimed to provide more evidence on safety of IVT in the very elderly. Methods: In this prospective multicenter study from the TRISP (Thrombolysis in Ischemic Stroke Patients) registry, we compared patients ≥90 years with those 〈 90 years using symptomatic intracranial hemorrhage (ECASS [European Cooperative Acute Stroke Study]-II criteria), death, and poor functional outcome in survivors (modified Rankin Scale score 3–5 for patients with prestroke modified Rankin Scale score ≤2 and modified Rankin Scale score 4–5 for patients prestroke modified Rankin Scale ≥3) at 3 months as outcomes. We calculated adjusted odds ratio with 95% CI using logistic regression models. Results: Of 16 974 eligible patients, 976 (5.7%) were ≥90 years. Patients ≥90 years had higher median National Institutes of Health Stroke Scale on admission (12 versus 8) and were more often dependent prior to the index stroke (prestroke modified Rankin Scale score of ≥3; 45.2% versus 7.4%). Occurrence of symptomatic intracranial hemorrhage (5.7% versus 4.4%, odds ratio adjusted 1.14 [0.83–1.57]) did not differ significantly between both groups. However, the probability of death (odds ratio adjusted 3.77 [3.14–4.53]) and poor functional outcome (odds ratio adjusted 2.63 [2.13–3.25]) was higher in patients aged ≥90 years. Results for the sample of centenarians (n=21) were similar. Conclusions: The probability of symptomatic intracranial hemorrhage after IVT in very elderly patients with stroke did not exceed that of their younger counterparts. The higher probability of death and poor functional outcome during follow-up in the very elderly seems not to be related to IVT treatment. Very high age itself should not be a reason to withhold IVT.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.122.039426
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
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    detail.hit.zdb_id: 1467823-8
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  • 8
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    Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation
    Society for Neuroscience ; 2015
    In:  The Journal of Neuroscience Vol. 35, No. 38 ( 2015-09-23), p. 13124-13132
    Details
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 35, No. 38 ( 2015-09-23), p. 13124-13132
    Abstract: Research over the past decade indicates a novel role for epigenetic mechanisms in memory formation. Of particular interest is chromatin modification by histone deacetylases (HDACs), which, in general, negatively regulate transcription. HDAC deletion or inhibition facilitates transcription during memory consolidation and enhances long-lasting forms of synaptic plasticity and long-term memory. A key open question remains: How does blocking HDAC activity lead to memory enhancements? To address this question, we tested whether a normal function of HDACs is to gate information processing during memory formation. We used a class I HDAC inhibitor, RGFP966 (C 21 H 19 FN 4 O), to test the role of HDAC inhibition for information processing in an auditory memory model of learning-induced cortical plasticity. HDAC inhibition may act beyond memory enhancement per se to instead regulate information in ways that lead to encoding more vivid sensory details into memory. Indeed, we found that RGFP966 controls memory induction for acoustic details of sound-to-reward learning. Rats treated with RGFP966 while learning to associate sound with reward had stronger memory and additional information encoded into memory for highly specific features of sounds associated with reward. Moreover, behavioral effects occurred with unusually specific plasticity in primary auditory cortex (A1). Class I HDAC inhibition appears to engage A1 plasticity that enables additional acoustic features to become encoded in memory. Thus, epigenetic mechanisms act to regulate sensory cortical plasticity, which offers an information processing mechanism for gating what and how much is encoded to produce exceptionally persistent and vivid memories. SIGNIFICANCE STATEMENT Here we provide evidence of an epigenetic mechanism for information processing. The study reveals that a class I HDAC inhibitor (Malvaez et al., 2013; Rumbaugh et al., 2015; RGFP966, chemical formula C 21 H 19 FN 4 O) alters the formation of auditory memory by enabling more acoustic information to become encoded into memory. Moreover, RGFP966 appears to affect cortical plasticity: the primary auditory cortex reorganized in a manner that was unusually “tuned-in” to the specific sound cues and acoustic features that were related to reward and subsequently remembered. We propose that HDACs control “informational capture” at a systems level for what and how much information is encoded by gating sensory cortical plasticity that underlies the sensory richness of newly formed memories.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    URL: Article
    DOI: 10.1523/JNEUROSCI.0914-15.2015
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2015
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    detail.hit.zdb_id: 604637-X
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  • 9
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    310 Evaluation of Orally Administered Megasphaera Elsdenii in Preconditioned Calves Abruptly Transitioned from a Receiving Diet with 4% Dietary Starch to a Growing Diet with 37% Dietary Starch
    Oxford University Press (OUP) ; 2023
    In:  Journal of Animal Science Vol. 101, No. Supplement_2 ( 2023-10-28), p. 226-227
    Details
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 101, No. Supplement_2 ( 2023-10-28), p. 226-227
    Abstract: The objective of this study was to evaluate the effects of orally administered Megasphaera elsdenii NCIMB 41125 (ME) in preconditioned calves abruptly transitioned from a receiving diet with 4% dietary starch [dry matter (DM) basis] to a growing diet with 37% dietary starch (DM basis). Preconditioned steers [n = 192; initial shrunk body weight (SBW) = 309 kg ± 20.6 kg] were assigned to microbial supplement treatment in a randomized complete block design. Treatments were CON: no ME; and LP: orally administered 20 mL of microbial supplement (2 × 1010 colony forming units ME/mL) immediately before diet change. Steers were abruptly changed from a receiving diet based upon soybean hulls and wheatlage with 4% dietary starch (DM basis) to a growing diet based upon high-moisture ear corn, dry-rolled corn, and wheatlage with 37% dietary starch (DM basis). Diets were switched on an equal DM basis to achieve abrupt change and steers were fed treatment diet for 49 d until study completion. Prior to study initiation, steers (n = 72; n = 3/pen) were fitted with wireless rumination tags to track daily activity and rumination time. Growth performance data and efficiency of dietary net energy utilization were analyzed with pen as the experimental unit, fixed effect of treatment, and random effect of block (location in the feedlot). Activity and rumination data were analyzed in a repeated measures analysis of covariance with individual animal as experimental unit, fixed effects of treatment, week, and their interaction, block (location in feedlot) as a random effect, and baseline activity and rumination as a covariate in the model. If no interaction was observed, main effect means of treatment and week were evaluated independently. For all statistical analysis, P ≤ 0.05 was declared significant and P ≤ 0.10 was declared a tendency. No difference (P ≥ 0.20) was observed between treatments for final SBW, average daily gain, dry matter intake, feed efficiency, calculated net energy (NE) for maintenance and gain or observed-to-expected ratio of NE for maintenance and gain. Additionally, no treatment × day differences (P ≥ 0.27) were observed for activity or rumination measures. Treatment effects (P & lt; 0.01) were observed for both activity and rumination where LP steers had a 2% increase and 2% decrease in minutes per day active and ruminating respectively. Additionally, a positive linear effect (P & lt; 0.01) of week was observed for minutes ruminating and quadratic effects (P & lt; 0.01) of week were observed for minutes active and ruminating. Oral administration of ME had no effects on growth performance or efficiency of dietary net energy utilization in steers transitioned from a receiving diet containing 4% starch (DM basis) to a growing diet containing 37% starch (DM basis).
    Type of Medium: Online Resource
    ISSN: 0021-8812 , 1525-3163
    URL: Article
    DOI: 10.1093/jas/skad341.254
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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    detail.hit.zdb_id: 1490550-4
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  • 10
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    312 Evaluation of Dietary Roughage Manipulation During the Feeding of Ractopamine Hydrochloride as a Method to Improve Ruminal Health and Control Liver Abscess Severity in Feedlot Steers
    Oxford University Press (OUP) ; 2023
    In:  Journal of Animal Science Vol. 101, No. Supplement_2 ( 2023-10-28), p. 227-228
    Details
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 101, No. Supplement_2 ( 2023-10-28), p. 227-228
    Abstract: The objective of this study was to determine if additional roughage inclusion to feedlot steer finishing diets during the feeding of ractopamine hydrochloride (RH) is an effective method to improve rumen health and control liver abscess severity. Steers [n = 64; initial shrunk body weight (SBW) = 633 kg ± 35.1 kg] were sourced from an unrelated trial and remained in their previous study pens; pens (n = 8) were assigned to dietary treatment in a completely randomized design. All steers on trial were fed a common 7% [dry matter (DM) basis] roughage equivalent (RE) finishing diet composed of dry-rolled corn, dried distillers grains plus solubles, corn silage, and grass hay for the 58 d preceding study initiation. Steers were fitted with rumination tags to track daily rumination. Dietary treatments were CON: no diet change; and 12R: 5% (DM basis) RE addition to diet via grass hay during the feeding of RH. Steers were fed RH (300 mg/steer/d), finished on treatment diets for 28 d, and harvested at a commercial beef processor. Growth performance, efficiency of dietary net energy (NE) utilization, and continuous carcass data were analyzed with pen as the experimental unit (EU) and fixed effect of treatment. Minutes ruminating was analyzed as an analysis of covariance with individual animal as the EU, fixed effects of treatment, days on feed (DOF) and their interaction, and baseline minutes ruminating as a covariate in the model. Liver abscess prevalence, rumen health, and categorical carcass data were analyzed with the Fisher’s exact test to determine differences between treatments. No difference (P ≥ 0.19) was observed for final SBW, average daily gain, dry matter intake, feed conversion efficiency, dressing percentage, hot carcass weight, calculated yield grade, marbling score, 12th rib fat thickness, calculated empty body fat, observed dietary NE for maintenance and gain, observed-to-expected dietary NE for maintenance and gain, or distribution of liver abscess prevalence, ruminitis score, or USDA yield grade. Ribeye area tended (P = 0.10) to differ between treatments with 12R steers exhibiting a 3.5% larger ribeye. Distribution of USDA quality grade differed (P = 0.003) between treatments with 12R steers having 25% more carcasses grading USDA average choice or better. A treatment × DOF interaction (P = 0.045) was observed for minutes ruminating per day. Daily minutes ruminating was increased (P ≤ 0.05) for 12R on d 1, 2, and 20 and tended to be increased (P ≤ 0.10) for 12R on days 10, 13, 24, and 25. Inclusion of an additional 5% RE to finishing cattle diets during a 28 d RH feeding period can be a management strategy to decrease risk of digestive upsets without sacrificing growth performance or carcass quality.
    Type of Medium: Online Resource
    ISSN: 0021-8812 , 1525-3163
    URL: Article
    DOI: 10.1093/jas/skad341.255
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 390959-1
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