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  • 1
    Online Resource
    Online Resource
    Robot-Assisted Surgery of an Iliac Artery Aneurysm: A Case Report
    SAGE Publications ; 2022
    In:  Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery Vol. 17, No. 6 ( 2022-11), p. 570-573
    Details
    In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, SAGE Publications, Vol. 17, No. 6 ( 2022-11), p. 570-573
    Abstract: Robot-assisted surgery has not yet been able to establish itself for vascular surgery. However, the preconditions for robot-assisted vascular interventions have changed fundamentally over the past years because of technological advances and extensive experience in other surgical disciplines. Hence, we describe a robot-assisted repair of an iliac artery aneurysm using a late-generation robotic platform. A 63-year-old male patient was diagnosed with an asymptomatic 30 mm aneurysm of the right common iliac artery. The operation was performed with the Da Vinci Xi system (Intuitive Surgical, Inc., Sunnyvale, CA, USA) using a direct transperitoneal approach to repair the aneurysm by interposition of a Dacron vascular prothesis. The total operating duration was 304 minutes without perioperative need for blood transfusion. The patient was discharged on the eighth postoperative day after an uneventful postoperative course. The case presented shows that robot-assisted surgery in the iliac axis can be performed safely with reasonable operating times.
    Type of Medium: Online Resource
    ISSN: 1556-9845 , 1559-0879
    URL: Article
    DOI: 10.1177/15569845221133328
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2223439-1
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  • 2
    Online Resource
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    Feasibility of a circulation model for the assessment of endovascular recanalization procedures and periprocedural thromboembolism in-vitro
    Springer Science and Business Media LLC ; 2019
    In:  Scientific Reports Vol. 9, No. 1 ( 2019-11-22)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-11-22)
    Abstract: Aim of this study was to establish a simple and highly reproducible physiological circulation model to investigate endovascular device performance. The developed circulation model included a pneumatically driven pulsatile pump to generate a flow rate of 2.7 L/min at 70 beats per minute. Sections from the superficial femoral arteries were used in order to simulate device/tissue interaction and a filter was integrated to analyze periinterventional thromboembolism of white, red and mixed thrombi. The working fluid (3 L) was a crystalloid solution constantly tempered at 36.5 °C. To evaluate the model, aspiration thrombectomy, stent-implantation and thrombectomy with the Fogarty catheter were performed. Usability of the model was measured by the System Usability Scale (SUS) – Score. Histological specimens were prepared and analyzed postinterventional to quantify tissue/device interaction. Moreover, micro- and macroembolism were evaluated for each thrombus entity and each device. Results were tested for normality using the D’Agostino-Pearson test. Statistical comparisons of two groups were performed using the Student’s t-test. All devices were able to remove the occlusions after a maximum of 2 attempts. First-pass-recanalization was not fully achieved for aspiration thrombectomy of mixed thrombi (90.6%), aspiration thrombectomy of red thrombi (84.4%) and stent-implantation in occlusions of red thrombi (92.2%). Most micro- and macroembolism were observed using the Fogarty catheter and after stent-implantation in occlusions of white thrombi. Histological examinations revealed a significant reduction of the vascular layers suggesting vascular damage after use of the Fogarty catheter (327.3 ± 3.5 μm vs. 440.6 ± 3.9 μm; p = 0.026). Analysis of SUS rendered a mean SUS-Score of 80.4 which corresponds to an excellent user acceptability of the model. In conclusion, we describe a stable, easy to handle and reproducible physiological circulation model for the simulation of endovascular thrombectomy including device performance and thromboembolism.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-019-53607-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2615211-3
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  • 3
    Online Resource
    Online Resource
    Effectiveness and Safety of Percutaneous Thrombectomy Devices: Comparison of Rotarex and Angiojet in a Physiological Circulation Model
    Elsevier BV ; 2020
    In:  European Journal of Vascular and Endovascular Surgery Vol. 59, No. 6 ( 2020-06), p. 983-989
    Details
    In: European Journal of Vascular and Endovascular Surgery, Elsevier BV, Vol. 59, No. 6 ( 2020-06), p. 983-989
    Type of Medium: Online Resource
    ISSN: 1078-5884
    URL: Article
    DOI: 10.1016/j.ejvs.2020.01.016
    RVK:
    XA 42122
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2005354-X
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  • 4
    Online Resource
    Online Resource
    Robotic-assisted abdominal aortic surgery: evidence and techniques
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Robotic Surgery Vol. 16, No. 6 ( 2022-03-04), p. 1265-1271
    Details
    In: Journal of Robotic Surgery, Springer Science and Business Media LLC, Vol. 16, No. 6 ( 2022-03-04), p. 1265-1271
    Abstract: In various disciplines, robotic-assisted surgery is a well-proven routine procedure, but have never been established in vascular surgery so far. This review summarizes the results to date of robotic-assisted abdominal aortic surgery (RAAS) in the treatment of aorto-iliac occlusive disease (AIOD) and abdominal aortic aneurysm (AAA). Web-based literature search of robotic-assisted surgical procedures on the abdominal aorta and iliac arteries between 1990 and 2020 including the Cochrane Library, OVID Medline, Embase, and PubMed medical databases. All studies conducting Robotic-assisted surgery were included in the quantitative analysis regarding operative and cross-clamping times, conversion rates, mortality and morbidity within the first 30 days, and in-hospital stay. Case reports and case studies ( 〈  5 patients) were not included. Twenty-four studies were deemed thematically eligible for inclusion; after exclusion of duplicate publications, nine met the inclusion criteria for further analysis. A total of 850 patients who had either abdominal aortic aneurysm or aorto-iliac occlusive disease underwent RAAS. One study of abdominal aortic aneurysm, three of aorto-iliac occlusive disease, and five studies of both disease entities were analyzed quantitatively. For AAA, conversion rates ranged from 13.1 to 20% and perioperative mortality ranged from 0 to 1.6% with in-hospital stay of 7 days. For aorto-iliac occlusive disease, conversion rates ranged from 0 to 20%, and perioperative mortality ranged from 0 to 3.6% with in-hospital stay of 5–8 days. RAAS has been shown to be technically feasible with acceptable short-term outcomes and questionable benefits in terms of in-hospital stay and complication rates. RAAS is currently considered only an outsider procedure. Randomized-controlled trials are indispensable for regular use in vascular surgery as well as a clear approval situation for the vascular sector.
    Type of Medium: Online Resource
    ISSN: 1863-2491
    URL: Article
    DOI: 10.1007/s11701-022-01390-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2268283-1
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  • 5
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    Large extracellular vesicles derived from human regulatory macrophages (L-EVMreg) attenuate CD3/CD28-induced T-cell activation in vitro
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Molecular Medicine
    Details
    In: Journal of Molecular Medicine, Springer Science and Business Media LLC
    Abstract: Macrophages belong to the innate immune system, and we have recently shown that in vitro differentiated human regulatory macrophages (Mreg) release large extracellular vesicles (L-EV Mreg ) with an average size of 7.5 μm which regulate wound healing and angiogenesis in vitro. The aim of this study was to investigate whether L-EV Mreg also affect the CD3/CD28-mediated activation of T-cells. Mreg were differentiated using blood monocytes and L-EV Mreg were isolated from culture supernatants by differential centrifugation. Activation of human T-cells was induced by CD3/CD28-coated beads in the absence or presence of Mreg or different concentrations of L-EV Mreg . Inhibition of T-cell activation was quantified by flow cytometry and antibodies directed against the T-cell marker granzyme B. Phosphatidylserine (PS) exposure on the surface of Mreg and L-EV Mreg was analyzed by fluorescence microscopy. Incubation of human lymphocytes with CD3/CD28 beads resulted in an increase of cell size, cell granularity, and number of granzyme B–positive cells ( P   〈  0.05) which is indicative of T-cell activation. The presence of Mreg (0.5 × 10 6  Mreg/ml) led to a reduction of T-cell activation (number of granzyme B–positive cells; P   〈  0.001), and a similar but less pronounced effect was also observed when incubating activated T-cells with L-EV Mreg ( P   〈  0.05 for 3.2 × 10 6 L-EV Mreg /ml). A differential analysis of the effects of Mreg and L-EV Mreg on CD4 + and CD8 + T-cells showed an inhibition of CD4 + T-cells by Mreg ( P   〈  0.01) and L-EV Mreg ( P   〈  0.05 for 1.6 × 10 6 L-EV Mreg /ml; P   〈  0.01 for 3.2 × 10 6 L-EV Mreg /ml). A moderate inhibition of CD8 + T-cells was observed by Mreg ( P   〈  0.05) and by L-EV Mreg ( P   〈  0.01 for 1.6 × 10 6 L-EV Mreg /ml and 3.2 × 10 6 L-EV Mreg /ml). PS was restricted to confined regions of the Mreg surface, while L-EV Mreg showed strong signals for PS in the exoplasmic leaflet. L-EV Mreg attenuate CD3/CD28-mediated activation of CD4 + and CD8 + T-cells. L-EV Mreg may have clinical relevance, particularly in the treatment of diseases associated with increased T-cell activity. Key messages Mreg release large extracellular vesicles (L-EV Mreg ) with an average size of 7.5 µm L-EV Mreg exhibit phosphatidylserine positivity L-EV Mreg suppress CD4 + and CD8 + T-cells L-EV Mreg hold clinical potential in T-cell-related diseases
    Type of Medium: Online Resource
    ISSN: 0946-2716 , 1432-1440
    URL: Article
    DOI: 10.1007/s00109-023-02374-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1462132-0
    SSG: 12
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  • 6
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    Repetitive application of remote ischemic conditioning (RIC) in patients with peripheral arterial occlusive disease (PAOD) as a non-invasive treatment option: study protocol for a randomised controlled clinical trial
    Springer Science and Business Media LLC ; 2022
    In:  BMC Cardiovascular Disorders Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: The best medical treatment (BMT) for most patients with early stage of peripheral arterial occlusive disease (PAOD) is often limited to gait training and pharmacological therapy besides endovascular surgery. The application of remote ischemic conditioning (RIC) has been described as a promising experimental strategy for the improvement of therapeutic outcome in cardiovascular disease but has not proven beneficial effects in clinical practice and treatment of PAOD yet. Methods Here we describe a prospective, randomized trial for the evaluation of possible effects of repeated application of RIC in patients with PAOD. This monocentric study will enrol 200 participants distributed to an intervention group receiving RIC + BMT and a control group only receiving BMT for four weeks. Patients are at least 18 years of age and have diagnosed PAOD Fontaine stage II b. Pain-free and total walking distance will be measured via treadmill test (primary endpoints). In addition, ankle-brachial index (ABI) and quality of life (QoL) will be assessed using the SF-36 and VascuQoL-6 questionnaire. Moreover, evaluation of markers for atherosclerosis, angiogenic profiling and mononuclear cell characterization will be performed using biochemical assays, proteome profiling arrays and flow cytometry (secondary endpoints). Discussion Our prospective, randomized monocentric trial is the first of its kind to analyse the effects of chronic and repetitive treatment with RIC in patients with PAOD and might provide important novel information on the molecular mechanisms associated with RIC in PAOD patients. Trial registration: Prospectively registered in the German Clinical Trials Register (Deutsche Register Klinischer Studien) Registration number: DRKS00025735; Date of registration: 01.07.2021.
    Type of Medium: Online Resource
    ISSN: 1471-2261
    URL: Article
    DOI: 10.1186/s12872-022-02795-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2059859-2
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  • 7
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    Online Resource
    PrEP-001 prophylactic effect against rhinovirus and influenza virus - RESULTS of 2 randomized trials
    Elsevier BV ; 2018
    In:  Antiviral Research Vol. 153 ( 2018-05), p. 70-77
    Details
    In: Antiviral Research, Elsevier BV, Vol. 153 ( 2018-05), p. 70-77
    Type of Medium: Online Resource
    ISSN: 0166-3542
    URL: Article
    DOI: 10.1016/j.antiviral.2018.03.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 1495861-2
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  • 8
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    Online Resource
    Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia–reperfusion injury
    Springer Science and Business Media LLC ; 2019
    In:  Journal of Translational Medicine Vol. 17, No. 1 ( 2019-12)
    Details
    In: Journal of Translational Medicine, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2019-12)
    Type of Medium: Online Resource
    ISSN: 1479-5876
    URL: Article
    DOI: 10.1186/s12967-019-1885-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2118570-0
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  • 9
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    Characterization of large extracellular vesicles (L-EV) derived from human regulatory macrophages (Mreg): novel mediators in wound healing and angiogenesis?
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Translational Medicine Vol. 21, No. 1 ( 2023-01-30)
    Details
    In: Journal of Translational Medicine, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2023-01-30)
    Abstract: Large extracellular vesicles (L-EV) with a diameter between 1 and 10 µm are released by various cell types. L-EV contain and transport active molecules which are crucially involved in cell to cell communication. We have shown that secretory products of human regulatory macrophages (Mreg) bear pro-angiogenic potential in-vitro and our recent findings show that Mreg cultures also contain numerous large vesicular structures similar to L-EV with so far unknown characteristics and function. Aim of this study To characterize the nature of Mreg-derived L-EV (L-EV Mreg ) and to gain insights into their role in wound healing and angiogenesis. Methods Mreg were differentiated using blood monocytes from healthy donors (N = 9) and L-EV Mreg were isolated from culture supernatants by differential centrifugation. Characterization of L-EV Mreg was performed by cell/vesicle analysis, brightfield/transmission electron microscopy (TEM), flow cytometry and proteome profiling arrays. The impact of L-EV Mreg on wound healing and angiogenesis was evaluated by means of scratch and in-vitro tube formation assays. Results Mreg and L-EV Mreg show an average diameter of 13.73 ± 1.33 µm (volume: 1.45 ± 0.44 pl) and 7.47 ± 0.75 µm (volume: 0.22 ± 0.06 pl) respectively. Flow cytometry analyses revealed similarities between Mreg and L-EV Mreg regarding their surface marker composition. However, compared to Mreg fewer L-EV Mreg were positive for CD31 (P  〈  0.01), CD206 (P  〈  0.05), CD103 (P  〈  0.01) and CD45 (P  〈  0.05). Proteome profiling suggested that L-EV Mreg contain abundant amounts of pro-angiogenic proteins (i.e. interleukin-8, platelet factor 4 and serpin E1). From a functional point of view L-EV Mreg positively influenced in-vitro wound healing (P  〈  0.05) and several pro-angiogenic parameters in tube formation assays (all segment associated parameters, P  〈  0.05; number of meshes, P  〈  0.05). Conclusion L-EV Mreg with regenerative and pro-angiogenic potential can be reproducibly isolated from in-vitro cultured human regulatory macrophages. We propose that L-EV Mreg could represent a putative therapeutic option for the treatment of chronic wounds and ischemia-associated diseases.
    Type of Medium: Online Resource
    ISSN: 1479-5876
    URL: Article
    DOI: 10.1186/s12967-023-03900-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2118570-0
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  • 10
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    Rethinking Conceptions of Unity: Schubert'sMoment musicalin A♭major, D. 780 (Op. 94) No. 2 : Rethinking Conceptions of Unity
    Wiley ; 2011
    In:  Music Analysis Vol. 30, No. 1 ( 2011-03), p. 58-88
    Details
    In: Music Analysis, Wiley, Vol. 30, No. 1 ( 2011-03), p. 58-88
    Type of Medium: Online Resource
    ISSN: 0262-5245
    URL: Issue
    URL: Article
    DOI: 10.1111/musa.2012.30.issue-1
    DOI: 10.1111/j.1468-2249.2011.00310.x
    RVK:
    LD 8700
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2001096-5
    SSG: 9,2
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