In:
Diabetes and Vascular Disease Research, SAGE Publications, Vol. 10, No. 2 ( 2013-03), p. 123-134
Abstract:
In diabetes, generalised microvascular disease and coronary artery disease (CAD) are likely to occur in parallel. We used a sidestream dark field (SDF) handheld imaging device to determine the relation between the labial microcirculation parameters and CAD in asymptomatic patients with diabetes. Methods: SDF imaging was validated for assessment of labial capillary density and tortuosity. Thereafter, mean labial capillary density and tortuosity were evaluated and compared in non-diabetic controls, and in asymptomatic patients with type 1 and type 2 diabetes. In diabetic patients, mean capillary density and tortuosity were compared according to the presence of CAD. Results: Both type 1 and type 2 diabetes were associated with increased capillary density and tortuosity. In diabetes, mean capillary density was an independent predictor of elevated coronary artery calcium (CAC) ( p = 0.03) and obstructive CAD on computed tomography angiography ( p = 0.01). Using a cut-off mean capillary density of 24.9 (per 0.63 mm 2 ) the negative predictive value was 84% and 89% for elevated CAC and obstructive CAD. Likewise, capillary tortuosity was an independent predictor of increased CAC ( p = 0.01) and obstructive CAD ( p = 0.04). Conclusion: Assessment of labial microcirculation parameters using SDF imaging is feasible and conveys the potential to estimate vascular morbidity in patients with diabetes, at bedside.
Type of Medium:
Online Resource
ISSN:
1479-1641
,
1752-8984
DOI:
10.1177/1479164112446302
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2250797-8
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