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  • 1
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2021
    In:  European Journal of Natural Sciences and Medicine Vol. 4, No. 2 ( 2021-10-01), p. 1-12
    In: European Journal of Natural Sciences and Medicine, Walter de Gruyter GmbH, Vol. 4, No. 2 ( 2021-10-01), p. 1-12
    Abstract: Particularly interest on herbs and plant extracts is due to their content of active principles with remarkable pharmacological properties. Different vegetal species contain natural antioxidants (polyphenols) used for their dermatological anti-inflammatory and healing activity, justified by their action on free radicals. The aim of this paper was to obtain selected phytopharmaceuticals formulations type gels with an increased antioxidant potential based on a mixture of fluid extracts from seaweeds species in the phylum Chlorophyta, Cladophora vagabunda (L.) C. Hoek, in the family Cladophoraceae, Ulva lactuca (L.) syn. Ulva rigida (L.), in the family Ulvaceae (sea lettuce) and species in the phylum Rhodophyta, Ceramium rubrum C. Agardh, in the famiy Ceramiaceae, frequently presents along the Romanian Black Sea coast. Fluid extracts concentration 10% were obtained using cold maceration extraction method, in solvents ethylic alcohol 40% and 70%. The obtained vegetal extracts were mixed in different ratio and analysed for physico-chemical properties, for the content of total phenols, chlorophylls, cartenoids, flavonoids and antioxidative capacity by photochemiluminescence method (ACL, Analytik Jena AG procedure). The selected mixed fluid extracts with greatest content of polyphenols and antioxidant activity were used for obtaining pharmaceutical forms type gels which were analyzed for the physical-chemical properties appearance, p H, spredability and total antioxidative capacity. Preliminary results emphasized that proposed pharmaceutical forms type gels had an appreciable antioxidant activity correlated with a good stability, an increased polyphenols content and would represent a possible new dermatological anti-inflammatory and healing preparation.
    Type of Medium: Online Resource
    ISSN: 2601-8691
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
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  • 2
    In: Antioxidants, MDPI AG, Vol. 12, No. 4 ( 2023-04-18), p. 951-
    Abstract: Lonicera caerulaea L. and Aronia melanocarpa (Michx.) Elliot fruits are frequently used for their health benefits as they are rich in bioactive compounds. They are recognized as a source of natural and valuable phytonutrients, which makes them a superfood. L. caerulea presents antioxidant activity three to five times higher than other berries which are more commonly consumed, such as blackberries or strawberries. In addition, their ascorbic acid level is the highest among fruits. The species A. melanocarpa is considered one of the richest known sources of antioxidants, surpassing currants, cranberries, blueberries, elderberries, and gooseberries, and contains one of the highest amounts of sorbitol. The non-edible leaves of genus Aronia became more extensively analyzed as a byproduct or waste material due to their high polyphenol, flavonoid, and phenolic acid content, along with a small amount of anthocyanins, which are used as ingredients in nutraceuticals, herbal teas, bio-cosmetics, cosmeceuticals, food and by the pharmaceutical industry. These plants are a rich source of vitamins, tocopherols, folic acid, and carotenoids. However, they remain outside of mainstream fruit consumption, being well known only to a small audience. This review aims to shed light on L. caerulaea and A. melanocarpa and their bioactive compounds as healthy superfoods with antioxidant, anti-inflammatory, antitumor, antimicrobial, and anti-diabetic effects, and hepato-, cardio-, and neuro-protective potential. In this view, we hope to promote their cultivation and processing, increase their commercial availability, and also highlight the ability of these species to be used as potential nutraceutical sources, helpful for human health.
    Type of Medium: Online Resource
    ISSN: 2076-3921
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704216-9
    SSG: 15,3
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  • 3
    In: Analele Universitatii "Ovidius" Constanta - Seria Chimie, Walter de Gruyter GmbH, Vol. 25, No. 1 ( 2014-6-1), p. 24-27
    Abstract: A rapid high performance liquid chromatography method, using a monolithic column, was developed for quantitative determinations of benzodiazepines (diazepam, clonazepam, lorazepam, midazolam) in whole blood. A liquid-liquid extraction step with n-chlorobutane isolates the drugs from alkalinized blood. The separation was carried out in reversed phase conditions using a Chromolith Performance (RP-18 100x4.6 mm) column. For the mobile phase, a mixture of a phosphate buffer (pH= 2.5)/acetonitrile (65/35 v/v), in isocratic mode at 2 mL/min. An ultraviolet spectrophotometer was used as the detector at the wavelength of 220 nm. The total run time of the analytical method is less than 4-6 minutes. The calibration curves showed linearity and the correlation coefficient of each individual curve was greater than 0.995. The method was linear over a concentration range of 0.03-0.6 μg/mL for clonazepam, lorazepam and midazolam. For diazepam of linearity was over the range 0.04-5.0μg/mL. Quantification limits ranged from 0.03-0.04μg/mL and the accuracy were from 80% to 105% for the recovery test. The results indicate that this analytical method is simple, specific, accuracy, sensitive, demonstrating from the validation data and a higher robustness. The proposed method is applied routinely in forensic toxicological analysis involving blood.
    Type of Medium: Online Resource
    ISSN: 1223-7221
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
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  • 4
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2015
    In:  Ovidius University Annals of Chemistry Vol. 26, No. 1 ( 2015-6-1), p. 12-19
    In: Ovidius University Annals of Chemistry, Walter de Gruyter GmbH, Vol. 26, No. 1 ( 2015-6-1), p. 12-19
    Abstract: Polyphenolic compounds were determined from a pharmaceutical (tincture) and a cosmetic preparation (rose water), both obtained from the Rosae damascenae flores. Separation of the phenolic compounds was done by a HPLC method, using a Zorbax XDB or equivalent column C18, 250 mm x 4,6 mm; 5 μm. A gradient elution was performed with phosphoric acid and acetonitrile eluted under gradient conditions. The flow rate was 1.5 mL/min and the injection volume was 20 μL. HPLC method for determination of caftaric acid presented in this paper, has been validated. The results were statistically analyzed with SPSS 10 software.
    Type of Medium: Online Resource
    ISSN: 2286-038X
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2015
    detail.hit.zdb_id: 2861448-3
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  • 5
    Online Resource
    Online Resource
    MedicHub Media ; 2018
    In:  Farmacist.ro Vol. 4, No. 183 ( 2018), p. 20-
    In: Farmacist.ro, MedicHub Media, Vol. 4, No. 183 ( 2018), p. 20-
    Type of Medium: Online Resource
    ISSN: 1584-6539
    URL: Issue
    Language: English
    Publisher: MedicHub Media
    Publication Date: 2018
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  • 6
    In: Applied Sciences, MDPI AG, Vol. 13, No. 11 ( 2023-06-05), p. 6830-
    Abstract: The aim is to evaluate the antibacterial and antifungal properties of the extracts obtained from Lysimachia nummularia L. in order to be able to introduce these extracts into pharmaceutical products and obtain useful products in the infectious and antifungal pathology of the oro-dental cavity. Extracts from different parts of the studied species have been obtained and chemically characterized: the total polyphenols in 40% ethanolic extracts have been determined and the caffeic and chlorogenic acids and trans-resveratrol, bioactive compounds involved in the antimicrobial properties of the studied species, have been identified, separated, and quantitatively determined. The antibacterial and antifungal activities of the extract of Lisymachia nummularia L. were determined using the diffusion method against a set of bacteria isolated from samples from different patients with diseases of the oro-dental cavity. The extract of Lisymachia nummularia L. exhibited antimicrobial activity against Gram-positive bacteria more than Gram-negative, where the effect was weaker; however, it had no antifungal effects on Candida albicans. Another aspect that must be emphasized is that the best antibacterial results were obtained from the aerial segment of the plant, the part where the highest concentration of polyphenols was identified in the studies presented. These results indicate that the pharmacological effects of the studied bacterial species support the use of extracts in obtaining pharmaceutical products that can be used to optimize treatment schemes in oro-dental diseases.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704225-X
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  • 7
    In: Applied Sciences, MDPI AG, Vol. 12, No. 19 ( 2022-09-26), p. 9649-
    Abstract: Honey and other bee products have been used for food and therapeutic purposes since ancient times. There are many varieties of honey with time-proven therapeutic properties, used in both traditional and modern medicine, along with various beekeeping products. In this study, conducted based on the dissemination of a questionnaire with 43 questions, an evaluation of the consumption of different types of honey for both food and therapeutic purposes was carried out. Hence, the frequency of the consumption of honey for food purposes was evaluated, as well as the pharmaceutical forms of honey and bee products utilized for therapeutic purposes, the population’s trust in their therapeutic potential, and their trust in the quality of bee products among the Romanian population. After processing the data, 917 responses were recorded, and it was found that the preferred types of honey were black locust (83.5%), multi-floral (81.9%), and linden (74.9%), and among the other bee products, the most consumed were propolis (44.2%) and bee pollen (29.2%). Regarding the use of honey as a sweetener, the majority of the respondents considered honey to be the healthiest option (81.7%), and regarding the use of honey for therapeutic purposes, most of the respondents stated that they used honey to strengthen the immune system (65.4%), as well as for skin treatment, laxative action, or energizing. The centralization and processing of the collected responses indicated a considerable level of readiness related to the increase in honey consumption in particular, but there is a need for the dissemination of effective information related to the nutritional and therapeutic value of beekeeping products to the population.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2704225-X
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  • 8
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2013
    In:  Analele Universitatii "Ovidius" Constanta - Seria Chimie Vol. 24, No. 2 ( 2013-12-1), p. 73-78
    In: Analele Universitatii "Ovidius" Constanta - Seria Chimie, Walter de Gruyter GmbH, Vol. 24, No. 2 ( 2013-12-1), p. 73-78
    Abstract: The present study investigated the influence of quercetol upon δ-aminolevulinic acid (△ -ALA) urine concentration as marker of lead poisoning. The study was conducted on six lots of 6 mature Wistar rats of both sexes, lots not poisoned treated with different concentrations of quercetol (Q1, Q2), control (L6M), lot poisoned untreated (L3Pb), lots poisoned and treated with Q (L4Q1Pb and L5Q2Pb). After 11 days urine from 24 hours was collected for △-ALA spectrophotometric assay and testing the significance of mean difference of by "t" test Student at p 〈 0.05. Statistical analysis of the data presented shows that compared to L2Q2 and L6M the amount of δ-ALA excreted in urine under quercetol influence (L4Q1Pb) shows statistical significance compared to (L2Q2) the amount of δ-ALA excreted in urine compared to (L3Pb) shows statistical significance. Different concentrations of quercetol (Q1, Q2), did not produce significant changes in the δ-ALA excreted compared with values of (L3Pb). Difference between means is probably due to sampling fluctuation, is not significant, reduced growth to eliminate δ-ALA on L4Q1Pb and L5Q2Pb is believed to be due to iron complex formation, reducing hemoglobin synthesis. From the results we conclude that hem biosynthesis does not start to grow under quercetol protection. The obtained data are not relevant statistical since interpretations were performed on non homogeneous groups in number of individuals, the percentage of mortality variability and high levels of standard deviation calculated from each lot.
    Type of Medium: Online Resource
    ISSN: 1223-7221
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2013
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  • 9
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2013
    In:  Analele Universitatii "Ovidius" Constanta - Seria Chimie Vol. 24, No. 2 ( 2013-12-1), p. 79-82
    In: Analele Universitatii "Ovidius" Constanta - Seria Chimie, Walter de Gruyter GmbH, Vol. 24, No. 2 ( 2013-12-1), p. 79-82
    Abstract: The aim of this paper is the valorization of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside in lozenges obtained by direct compression and quality lozenges evaluation according to Romanian and European pharmacopoeia tests. The resulting lozenges with a 600 mg concentration of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside were evaluated using the following tests: appearance and mass uniformity (20 lozenges) disintegration time (6 lozenges), hardness (10 lozenges), anthocyanins assay expressed as cyanidin-3-glucoside using a spectrometric method at pH differential values. The results are expressed as means± standard deviation. The tablets for the two formulas have the same appearance (flat, round, colored in purple - red, non gritty), the dimensional characteristics (height, thickness) are different, average mass complies the pharmacopoeia standards. The lozenges from formula 2 have a higher resistance (215.7 N) and a lower disintegration time (11 min.) according to the official recommended values, due to differences from carbopol polymers differences in properties at the same concentration used in the two formulas. Using the direct compressible products described in this study, the direct compression technique can be easily applied for the manufacture of lozenges, thus ensuring their stability by avoiding heat and humidity factors during the manufacturing process. The resulting lozenges from formula 1 respect the quality specifications provided by the Romanian Pharmacopoeia Xth edition, the European Pharmacopoeia. The lozenges presented a high mechanical resistance (110 N) and a good disintegration time (15 min.)
    Type of Medium: Online Resource
    ISSN: 1223-7221
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2013
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  • 10
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2016
    In:  Ovidius University Annals of Chemistry Vol. 27, No. 1 ( 2016-6-1), p. 58-61
    In: Ovidius University Annals of Chemistry, Walter de Gruyter GmbH, Vol. 27, No. 1 ( 2016-6-1), p. 58-61
    Abstract: Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.
    Type of Medium: Online Resource
    ISSN: 2286-038X
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2861448-3
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