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  • 1
    Online Resource
    Online Resource
    Structural brain indices and executive functioning in multiple sclerosis: A review
    Informa UK Limited ; 2016
    In:  Journal of Clinical and Experimental Neuropsychology Vol. 38, No. 3 ( 2016-03-15), p. 261-274
    Details
    In: Journal of Clinical and Experimental Neuropsychology, Informa UK Limited, Vol. 38, No. 3 ( 2016-03-15), p. 261-274
    Type of Medium: Online Resource
    ISSN: 1380-3395 , 1744-411X
    URL: Article
    DOI: 10.1080/13803395.2015.1105199
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 1479533-4
    SSG: 5,2
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  • 2
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    Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial
    Elsevier BV ; 2023
    In:  The Lancet Digital Health Vol. 5, No. 10 ( 2023-10), p. e668-e678
    Details
    In: The Lancet Digital Health, Elsevier BV, Vol. 5, No. 10 ( 2023-10), p. e668-e678
    Type of Medium: Online Resource
    ISSN: 2589-7500
    URL: Article
    DOI: 10.1016/S2589-7500(23)00109-7
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2972368-1
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  • 3
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    An Examination of Racial/Ethnic Differences on the Neurobehavioral Symptom Inventory Among Veterans Completing the Comprehensive Traumatic Brain Injury Evaluation: A Veterans Affairs Million Veteran Program Study
    Oxford University Press (OUP) ; 2023
    In:  Archives of Clinical Neuropsychology Vol. 38, No. 6 ( 2023-08-24), p. 929-943
    Details
    In: Archives of Clinical Neuropsychology, Oxford University Press (OUP), Vol. 38, No. 6 ( 2023-08-24), p. 929-943
    Abstract: The purpose of this study was to explore racial/ethnic differences in neurobehavioral symptom reporting and symptom validity testing among military veterans with a history of traumatic brain injury (TBI). Method Participants of this observational cross-sectional study (N = 9,646) were post-deployed Iraq-/Afghanistan-era veterans enrolled in the VA’s Million Veteran Program with a clinician-confirmed history of TBI on the Comprehensive TBI Evaluation (CTBIE). Racial/ethnic groups included White, Black, Hispanic, Asian, Multiracial, Another Race, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander. Dependent variables included neurobehavioral symptom domains and symptom validity assessed via the Neurobehavioral Symptom Inventory (NSI) and Validity-10, respectively. Results Chi-square analyses showed significant racial/ethnic group differences for vestibular, somatic/sensory, and affective symptoms as well as for all Validity-10 cutoff scores examined (≥33, ≥27, ≥26, & gt;22, ≥22, ≥13, and ≥7). Follow-up analyses compared all racial/ethnic groups to one another, adjusting for sociodemographic- and injury-related characteristics. These analyses revealed that the affective symptom domain and the Validity-10 cutoff of ≥13 revealed the greatest number of racial/ethnic differences. Conclusions Results showed significant racial/ethnic group differences on neurobehavioral symptom domains and symptom validity testing among veterans who completed the CTBIE. An enhanced understanding of how symptoms vary by race/ethnicity is vital so that clinical care can be appropriately tailored to the unique needs of all veterans. Results highlight the importance of establishing measurement invariance of the NSI across race/ethnicity and underscore the need for ongoing research to determine the most appropriate Validity-10 cutoff score(s) to use across racially/ethnically diverse veterans.
    Type of Medium: Online Resource
    ISSN: 1873-5843
    URL: Article
    DOI: 10.1093/arclin/acad005
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2003528-7
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  • 4
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    H - 37 Impact of Barriers to Healthcare Access on Cognition and Accelerated Brain Aging in Diverse Persons with Multiple Sclerosis: Preliminary Pilot Data
    Oxford University Press (OUP) ; 2023
    In:  Archives of Clinical Neuropsychology ( 2023-10-08)
    Details
    In: Archives of Clinical Neuropsychology, Oxford University Press (OUP), ( 2023-10-08)
    Abstract: Racially/ethnically diverse persons with multiple sclerosis (pwMS) have worse outcomes than their white counterparts. Barriers to healthcare access may contribute to these disparities, though much remains unknown. The current pilot study investigates the impact of barriers to healthcare on cognition and accelerated brain aging in diverse pwMS. We hypothesize that greater barriers to healthcare will be associated with poorer cognitive performance and increased brain aging. Method Eighteen middle-aged pwMS (40–60 years) were included. Barriers to healthcare access was evaluated using total and subscale (skills, marginalization, expectations, knowledge, and pragmatics) scores of the modified Barriers to Care Questionnaire. Cognition was measured using raw scores from the Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory Test-Revised (BVMT-R), and California Verbal Learning Test-II (CVLT-II). Accelerated brain aging was calculated by subtracting chronological age from predicted brain age based on the brainageR paradigm. Results Given established directional hypotheses, one tailed correlations were conducted. Greater marginalization-related barriers to healthcare were associated with poorer performance on the SDMT (r = −0.409, p = 0.046). Greater knowledge-based barriers to healthcare were associated with increased brain aging (r = −0.615, p = 0.004). Lastly, brain age was significantly related to immediate (r = −0.653, p = 0.003) and delayed (r = −0.549, p = 0.014) visual memory, such that increased brain age was associated with poorer visual memory. Conclusion To the authors’ knowledge, this is among the first studies to examine the impact of barriers to healthcare on cognition and brain health in diverse pwMS. It demonstrates the importance of sociocultural determinants when examining outcomes in MS. This work has implications for culturally informed research and clinical care.
    Type of Medium: Online Resource
    ISSN: 1873-5843
    URL: Article
    DOI: 10.1093/arclin/acad067.355
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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  • 5
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    H - 25 A Pilot Study of Coping and Cognition: Examining the Influence of Executive Functioning on Coping Strategies among Diverse Persons Living with Multiple Sclerosis
    Oxford University Press (OUP) ; 2023
    In:  Archives of Clinical Neuropsychology ( 2023-10-08)
    Details
    In: Archives of Clinical Neuropsychology, Oxford University Press (OUP), ( 2023-10-08)
    Abstract: Coping style has been identified as a potential strategy to lessen the impact of negative symptoms in persons with MS (pwMS). Prior work demonstrates that individuals with executive dysfunction are less likely to use effective coping strategies. Much remains unknown about the relationship between executive functioning (EF) and coping style, however, especially in diverse pwMS. The current pilot study aims to examine this relationship further. Methods Eighteen middle aged pwMS (10 = Latino/a, 6 = African American, 1 = Asian, 1 = Biracial) underwent evaluations for EF and coping styles. EF was assessed using the Stroop Color-Word (SCW), Oral Trail Making Test B, and Controlled Oral Word Association Test. Coping was assessed using the three subscales of the Brief-COPE: problem-focused, positive emotion-focused, and avoidant coping. Results Given the small sample size, data were interpreted in terms of effect size rather than p-values. Bivariate correlations were conducted between each EF test and coping subscale. Results demonstrated a medium-high effect size (r = 0.447) between SCW and problem-focused coping, such that better performance on the SCW was associated with greater problem-focused coping. Similarly, there was a moderate effect size (r = 0.326) between SCW and positive emotion-focused coping, with better performance on SCW related to greater positive emotion-focused coping. There were no notable relationships between EF and avoidant coping. Conclusions This study is among the first to demonstrate a relationship between EF and coping style in a sample of diverse pwMS. These results have implications for interventions that may improve coping, particularly among diverse groups who face unique challenges in coping with their disease.
    Type of Medium: Online Resource
    ISSN: 1873-5843
    URL: Article
    DOI: 10.1093/arclin/acad067.343
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2003528-7
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  • 6
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    Associations of White Matter and Basal Ganglia Microstructure to Cognitive Fatigue Rate in Multiple Sclerosis
    Frontiers Media SA ; 2022
    In:  Frontiers in Neurology Vol. 13 ( 2022-7-4)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 13 ( 2022-7-4)
    Abstract: Fatigue, including cognitive fatigue, is one of the most debilitating symptoms reported by persons with multiple sclerosis (pwMS). Cognitive fatigue has been associated with disruptions in striato-thalamo-cortical and frontal networks, but what remains unknown is how the rate at which pwMS become fatigued over time relates to microstructural properties within the brain. The current study aims to fill this gap in knowledge by investigating how cognitive fatigue rate relates to white matter and basal ganglia microstructure in a sample of 62 persons with relapsing-remitting MS. Participants rated their level of cognitive fatigue at baseline and after each block (x7) of a within-scanner cognitive fatigue inducing task. The slope of the regression line of all eight fatigue ratings was designated as “cognitive fatigue rate.” Diffusional kurtosis imaging maps were processed using tract-based spatial statistics and regional analyses (i.e., basal ganglia) and associated with cognitive fatigue rate. Results showed cognitive fatigue rate to be related to several white matter tracts, with many having been associated with basal ganglia connectivity or the previously proposed “fatigue network.” In addition, cognitive fatigue rate was associated with the microstructure within the putamen, though this did not survive multiple comparisons correction. Our approach of using cognitive fatigue rate, rather than trait fatigue, brings us closer to understanding how brain pathology may be impacting the experience of fatigue in the moment, which is crucial for developing interventions. These results hold promise for continuing to unpack the complex construct that is cognitive fatigue.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    DOI: 10.3389/fneur.2022.911012
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564214-5
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  • 7
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    Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Neurology Vol. 269, No. 10 ( 2022-10), p. 5531-5540
    Details
    In: Journal of Neurology, Springer Science and Business Media LLC, Vol. 269, No. 10 ( 2022-10), p. 5531-5540
    Type of Medium: Online Resource
    ISSN: 0340-5354 , 1432-1459
    URL: Article
    DOI: 10.1007/s00415-022-11205-9
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1421299-7
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  • 8
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    Signal Detection Theory as a Novel Tool to Understand Cognitive Fatigue in Individuals With Multiple Sclerosis
    Frontiers Media SA ; 2022
    In:  Frontiers in Behavioral Neuroscience Vol. 16 ( 2022-3-16)
    Details
    In: Frontiers in Behavioral Neuroscience, Frontiers Media SA, Vol. 16 ( 2022-3-16)
    Abstract: Multiple Sclerosis (MS) affects 2.8 million persons worldwide. One of the most persistent, pervasive, and debilitating symptoms of MS is cognitive fatigue. While this has been known for over a century, cognitive fatigue has been difficult to study because patients’ subjective (self-reported) cognitive fatigue has consistently failed to correlate with more objective measures, such as reaction time (RT) and accuracy. Here, we investigated whether more nuanced metrics of performance, specifically the metrics of Signal Detection Theory (SDT), would show a relationship to cognitive fatigue even if RT and accuracy did not. We also measured brain activation to see whether SDT metrics were related to activation in brain areas that have been shown to be sensitive to cognitive fatigue. Fifty participants (30 MS, 20 controls) took part in this study and cognitive fatigue was induced using four blocks of a demanding working memory paradigm. Participants reported their fatigue before and after each block, and their performance was used to calculate SDT metrics (Perceptual Certainty and Criterion) and RT and accuracy. The results showed that the SDT metric of Criterion (i.e., response bias) was positively correlated with subjective cognitive fatigue. Moreover, the activation in brain areas previously shown to be related to cognitive fatigue, such as the striatum, was also related to Criterion. These results suggest that the metrics of SDT may represent a novel tool with which to study cognitive fatigue in MS and other neurological populations. These results hold promise for characterizing cognitive fatigue in MS and developing effective interventions in the future.
    Type of Medium: Online Resource
    ISSN: 1662-5153
    URL: Article
    DOI: 10.3389/fnbeh.2022.828566
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2452960-6
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  • 9
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    Evaluating the effects of brain injury, disease and tasks on cognitive fatigue
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-11-17)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-11-17)
    Abstract: Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, and cerebral activation within and across populations by combining the data from two cross-sectional studies. Individuals with multiple sclerosis (MS) were included to model CF resulting from neurological disease; individuals who had sustained a traumatic brain injury (TBI) were included to model CF resulting from neurological insult; both groups were compared with a control group (Controls). CF was induced while neuroimaging data was acquired using two different tasks. CF significantly differed between the groups, with the clinical groups reporting more CF than Controls—a difference that was statistically significant for the TBI group and trended towards significance for the MS group. The accrual of CF did not differ across the three groups; and CF ratings were consistent across tasks. Increasing CF was associated with longer response time for all groups. The brain activation in the caudate nucleus and the thalamus was consistently correlated with CF in all three groups, while more dorsally in the caudate, activation differed across the groups. These results suggest the caudate and thalamus to be central to CF while more dorsal aspects of the caudate may be sensitive to damage associated with particular types of insult.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-023-46918-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2615211-3
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  • 10
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    A-50 Representation and Generalizability in Neuropsychologically-Focused Multiple Sclerosis Research: Who Are we Studying and Who Does it Apply to?
    Oxford University Press (OUP) ; 2021
    In:  Archives of Clinical Neuropsychology Vol. 36, No. 6 ( 2021-08-31), p. 1091-1091
    Details
    In: Archives of Clinical Neuropsychology, Oxford University Press (OUP), Vol. 36, No. 6 ( 2021-08-31), p. 1091-1091
    Abstract: MS impacts individuals from diverse racial/ethnic groups, yet they are not always well represented in research. The objectives of the current study are to examine how often neuropsychologically-focused MS research (NFMSR) studies: (1) include diverse populations; (2) explicitly describe the race/ethnicity of their participants; and (3) discuss generalizability/cultural implications. Methods A sample of NFMSR studies (defined here as studies examining cognitive functioning, mood, neuroimaging, fatigue, and quality of life) published within major journals between 2017–2020 were identified. Articles focusing on clinically isolated syndrome or pediatric populations were excluded. Variables of interest included sample size, sex/gender, race/ethnicity, age, education, socioeconomic status (SES), generalizability/cultural limitations, discussion of racism/disparities, and recruitment procedures. Data were coded and analyzed in IBM’s Statistical Package for the Social Sciences (SPSS; version 27). Results Race/ethnicity was not often reported in NFMSR studies, and when described, the representation of diverse individuals with MS was low (i.e., samples were mostly Caucasian). In addition, specific information about recruitment methods and SES was lacking. Generalizability/cultural implications or disparities were not discussed in the majority of studies. Report of education was variable, while sex, age, disease course, and EDSS were more often reported. Conclusions To the authors’ knowledge, this is the first study to highlight the significant gaps in representation in NFMSR. These results have significant implications for how we should be using the current literature to characterize patients or guide treatments. In addition, the current study serves as a call to action for MS researchers to work toward more inclusive and generalizable studies.
    Type of Medium: Online Resource
    ISSN: 1873-5843
    URL: Article
    DOI: 10.1093/arclin/acab062.68
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
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