In:
Acta Paediatrica, Wiley, Vol. 97, No. 7 ( 2008-07), p. 861-865
Abstract:
Aim: To investigate polymorphisms in the serotonin transporter (5‐HTT) gene in cases of sudden infant death syndrome (SIDS) and controls, and further to elucidate a possible relationship between 5‐HTT genotypes and external risk factors for SIDS. Method: The subjects investigated consist of 163 SIDS cases and 243 controls. Polymorphisms in both the promoter and intron 2 of the 5‐HTT gene were investigated, and the genotypes were determined using polymerase chain reaction (PCR) and gel electrophoresis. Results: In the promoter, there was a tendency for the L allele and L/L genotype to be found more often in the SIDS cases than in the controls (p = 0.05 and p = 0.07, respectively). Regarding the intron 2 polymorphism, there were no differences between the groups, and the SIDS cases were not found to have a higher frequency of either the L/L‐12/12 genotype or the L‐12 haplotype than the controls. When investigating possible correlations between genotype and risk factors for SIDS, there was a tendency towards different distribution of the promoter genotypes in cases found dead prone compared to cases found dead in other sleeping positions (p = 0.06). Conclusion: Polymorphisms in the promoter of the 5‐HTT gene may be of importance with regard to SIDS.
Type of Medium:
Online Resource
ISSN:
0803-5253
,
1651-2227
DOI:
10.1111/apa.2008.97.issue-7
DOI:
10.1111/j.1651-2227.2008.00813.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
1492629-5
detail.hit.zdb_id:
1501466-6
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