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  • 1
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    Online Resource
    Ethnic differences in childhood right and left cardiac structure and function assessed by cardiac magnetic resonance imaging
    Springer Science and Business Media LLC ; 2021
    In:  European Journal of Pediatrics Vol. 180, No. 4 ( 2021-04), p. 1257-1266
    Details
    In: European Journal of Pediatrics, Springer Science and Business Media LLC, Vol. 180, No. 4 ( 2021-04), p. 1257-1266
    Abstract: Ethnic differences in cardiovascular risk factors and disease are well-known and may originate in early-life. We examined the ethnic differences in cardiac structure and function in children using cardiac magnetic resonance imaging in a European migrant population, and whether any difference was explained by early life factors. We used a prospective population-based cohort study among 2317 children in Rotterdam, the Netherlands. We compared children from Dutch (73%), Cape Verdean (3.5%), Dutch Antillean (3.3%), Moroccan (6.1%), Surinamese-Creoles (3.9%), Surinamese-Hindustani (3.4%), and Turkish (6.4%) background. Main outcomes were cMRI-measured cardiac structures and function. Cardiac outcomes were standardized on body surface area. Cape Verdean, Surinamese-Hindustani, and Turkish children had smaller right ventricular end-diastolic volume and left ventricular end-diastolic volume relative to their body size than Dutch children ( p 〈 0.05). These results were not fully explained by fetal and childhood factors. Right ventricular ejection fraction and left ventricular ejection fraction did not differ between ethnicities after adjustment for fetal and childhood factors. Conclusion : Right ventricular end-diastolic volume and left ventricular end-diastolic volume differ between ethnic subgroups in childhood, without affecting ejection fraction. Follow-up studies are needed to investigate whether these differences lead to ethnic differences in cardiac disease in adulthood. What is Known: • Ethnic differences in cardiovascular risk factors and disease are well-known and may originate in early-life. • The prevalence of cardiovascular disease differs between ethnic groups . What is New: • We examined ethnic differences in left and right cardiac structure and function in children using cMRI. • Right and left cardiac dimensions differ between ethnic groups in childhood and are only partly explained by fetal and childhood factors.
    Type of Medium: Online Resource
    ISSN: 0340-6199 , 1432-1076
    URL: Article
    DOI: 10.1007/s00431-020-03869-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2647723-3
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  • 2
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    Pericardial adipose tissue, cardiac structures, and cardiovascular risk factors in school-age children
    Oxford University Press (OUP) ; 2021
    In:  European Heart Journal - Cardiovascular Imaging Vol. 22, No. 3 ( 2021-02-22), p. 307-313
    Details
    In: European Heart Journal - Cardiovascular Imaging, Oxford University Press (OUP), Vol. 22, No. 3 ( 2021-02-22), p. 307-313
    Abstract: We examined the associations of pericardial adipose tissue with cardiac structures and cardiovascular risk factors in children. Methods and results  We performed a cross-sectional analysis in a population-based cohort study among 2892 children aged 10 years (2404 normal weight and 488 overweight/obese). Pericardial adipose tissue mass was estimated by magnetic resonance imaging (MRI) and indexed on height3. Left ventricular mass (LVM) and left ventricular mass-to-volume ratio (LMVR) were estimated by cardiac MRI. Cardiovascular risk factors included android adipose tissue percentage obtained by Dual-energy X-ray absorptiometry, blood pressure and glucose, insulin, cholesterol, and triglycerides concentrations. Adverse outcomes were defined as values above the 75 percentile. Median pericardial adipose tissue index was 3.6 (95% range 1.6–7.1) among normal weight and 4.7 (95% range 2.0–8.9) among overweight children. A one standard deviation (1 SD) higher pericardial adipose tissue index was associated with higher LMVR [0.06 standard deviation scores, 95% confidence interval (CI) 0.02–0.09], increased odds of high android adipose tissue [odd ratio (OR) 2.08, 95% CI 1.89–2.29] , high insulin concentrations (OR 1.17, 95% CI 1.06–1.30), an atherogenic lipid profile (OR 1.22, 95% CI 1.11–1.33), and clustering of cardiovascular risk factors (OR 1.56, 95% CI 1.36–1.79). Pericardial adipose tissue index was not associated with LVM, blood pressure, and glucose concentrations. The associations showed largely the same directions but tended to be weaker among normal weight than among overweight children. Conclusion  Pericardial adipose tissue is associated with cardiac adaptations and cardiovascular risk factors already in childhood in both normal weight and overweight children.
    Type of Medium: Online Resource
    ISSN: 2047-2404 , 2047-2412
    URL: Article
    DOI: 10.1093/ehjci/jeaa031
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2042482-6
    detail.hit.zdb_id: 2647943-6
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  • 3
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    Associations Between Blood Biomarkers, Cardiac Function, and Adverse Outcome in a Young Fontan Cohort
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Journal of the American Heart Association Vol. 10, No. 5 ( 2021-03-02)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. 5 ( 2021-03-02)
    Abstract: Patients who have undergone the Fontan procedure are at high risk of circulatory failure. In an exploratory analysis we aimed to determine the prognostic value of blood biomarkers in a young cohort who have undergone the Fontan procedure. Methods and Results In multicenter prospective studies patients who have undergone the Fontan procedure underwent blood sampling, cardiopulmonary exercise testing, and stress cardiac magnetic resonance imaging. Several biomarkers including NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), GDF‐15 (growth differentiation factor 15), Gal‐3 (galectin‐3), ST2 (suppression of tumorigenicity 2), DLK‐1 (protein delta homolog 1), FABP‐4 (fatty acid‐binding protein 4), IGFBP‐1 (insulin‐like growth factor‐binding protein 1), IGFBP‐7, MMP‐2 (matrix metalloproteinase 2), and vWF (von Willebrand factor) were assessed in blood at 9.6 (7.1–12.1) years after Fontan completion. After this baseline study measurement, follow‐up information was collected on the incidence of adverse cardiac events, including cardiac death, out of hospital cardiac arrest, heart transplantation (listing), cardiac reintervention (severe events), hospitalization, and cardioversion/ablation for arrhythmias was collected and the relation with blood biomarkers was assessed by Cox proportional hazard analyses. The correlation between biomarkers and other clinical parameters was evaluated. We included 133 patients who have undergone the Fontan procedure, median age 13.2 (25th, 75th percentile 10.4–15.9) years, median age at Fontan 3.2 (2.5–3.9) years. After a median follow‐up of 6.2 (4.9–6.9) years, 36 (27.1%) patients experienced an event of whom 13 (9.8%) had a severe event. NT‐proBNP was associated with (all) events during follow‐up and remained predictive after correction for age, sex, and dominant ventricle (hazard ratio, 1.89; CI, 1.32–2.68). The severe event‐free survival was better in patients with low levels of GDF‐15 ( P =0.005) and vWF ( P =0.008) and high levels of DLK‐1 ( P =0.041). There was a positive correlation (β=0.33, P =0.003) between DLK‐1 and stress cardiac magnetic resonance imaging functional reserve. Conclusions NT‐proBNP, GDF‐15, vWF, DLK‐1, ST‐2 FABP‐4, and IGFBP‐7 levels relate to long‐term outcome in young patients who have undergone the Fontan procedure.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.119.015022
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2653953-6
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  • 4
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    Third Trimester Fetal Cardiac Blood Flow and Cardiac Outcomes in School‐Age Children Assessed By Magnetic Resonance Imaging
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of the American Heart Association Vol. 8, No. 16 ( 2019-08-20)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 16 ( 2019-08-20)
    Abstract: An adverse fetal environment leads to fetal hemodynamic adaptations with cardiac flow alterations that may subsequently affect cardiac development. We examined the associations of third trimester placental and fetal cardiac hemodynamics with cardiac outcomes in school‐age children. Methods and Results We performed a population‐based prospective cohort study among 547 mothers and their children. At a gestational age of 30.4 (95% range 28.4–32.7) weeks, we measured umbilical and cerebral artery resistance, cardiac output, and tricuspid and mitral E/A waves with Doppler. At the median age of 10.0 years (95% range 9.4–11.7) we measured cardiac outcomes with cardiac magnetic resonance imaging. Cardiac outcomes included right ventricular end‐diastolic volume) and right ventricular ejection fraction, left ventricular end diastolic volume and left ventricular ejection fraction, left ventricular mass, and left ventricular mass‐to‐volume ratio as left ventricular mass/left ventricular end diastolic volume. Higher third‐trimester umbilical artery resistance was associated with higher childhood right ventricular ejection fraction ( P value 〈 0.05), but not with other cardiac outcomes. The third‐trimester umbilical artery‐cerebral artery pulsatility index ratio was not associated with childhood cardiac outcomes. Higher third‐trimester fetal left cardiac output was associated with lower childhood left ventricular ejection fraction and higher left ventricular mass‐to‐volume ratio ( P value 〈 0.05). Third‐trimester fetal right cardiac output was not associated with childhood cardiac outcomes. A higher third‐trimester fetal tricuspid valve E/A ratio was associated with higher childhood right ventricular ejection fraction ( P value 〈 0.05). Conclusions Our findings suggest that fetal cardiac fetal blood flow redistribution may have long‐term effects on cardiac structure and function. These results should be considered as hypothesis generating and need further replication.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.119.012821
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2653953-6
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  • 5
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    Gestational hypertensive disorders and blood pressure and childhood cardiac outcomes: A prospective cohort study
    Wiley ; 2023
    In:  BJOG: An International Journal of Obstetrics & Gynaecology Vol. 130, No. 10 ( 2023-09), p. 1226-1237
    Details
    In: BJOG: An International Journal of Obstetrics & Gynaecology, Wiley, Vol. 130, No. 10 ( 2023-09), p. 1226-1237
    Abstract: To assess whether gestational hypertensive disorders and higher gestational blood pressure were associated with subclinical changes in offspring cardiac structure and function during childhood. Design Population‐based prospective cohort study. Setting Rotterdam, the Netherlands. Population A cohort of 2502 mother–offspring pairs. Methods Maternal blood pressure was measured in early, mid and late pregnancy, and information on gestational disorders were obtained from medical records. Offspring cardiac measurements were assessed by Cardiovascular Magnetic Resonance at 10 years. Main outcome measures Left and right ventricular end‐diastolic volumes (LVEDVs and RVEDVs), and ejection fractions, and left ventricular mass (LVM). Results Offspring exposed to pre‐eclampsia had a lower right ventricular ejection fraction (RVEF) (difference, −0.31 SDS; 95% CI −0.60, −0.02); however, no associations with other cardiac outcomes were present. Higher maternal diastolic blood pressure (DBP) in early and late pregnancy was associated with lower LVEDVs and RVEDVs ( p   〈  0.05), with the strongest effect in early pregnancy. No associations of systolic blood pressure (SBP) with offspring outcomes were present. These associations persisted after additional adjustment for birth and child factors. Paternal SBP and DBP were not associated with offspring cardiac outcomes. Conclusions No consistent associations of gestational hypertensive disorder status with childhood cardiac outcomes were present. Higher maternal DBP throughout pregnancy was associated with lower childhood LVEDVs and RVEDVs. Stronger maternal–offspring rather than paternal–offspring associations were present, which may suggest that suboptimal maternal gestational haemodynamic adaptations affects offspring cardiac structure through direct intrauterine effects. Further studies are needed to replicate these findings and examine the underlying mechanisms.
    Type of Medium: Online Resource
    ISSN: 1470-0328 , 1471-0528
    URL: Issue
    URL: Article
    DOI: 10.1111/bjo.v130.10
    DOI: 10.1111/1471-0528.17468
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2036469-6
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  • 6
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    Intraatrial Repair of Transposition of the Great Arteries: Use of MR Imaging after Exercise to Evaluate Regional Systemic Right Ventricular Function
    Radiological Society of North America (RSNA) ; 2005
    In:  Radiology Vol. 237, No. 3 ( 2005-12), p. 861-867
    Details
    In: Radiology, Radiological Society of North America (RSNA), Vol. 237, No. 3 ( 2005-12), p. 861-867
    Type of Medium: Online Resource
    ISSN: 0033-8419 , 1527-1315
    URL: Article
    DOI: 10.1148/radiol.2373041347
    RVK:
    XA 10000
    Language: English
    Publisher: Radiological Society of North America (RSNA)
    Publication Date: 2005
    detail.hit.zdb_id: 80324-8
    detail.hit.zdb_id: 2010588-5
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  • 7
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    Exercise MR Imaging in the Assessment of Pulmonary Regurgitation and Biventricular Function in Patients after Tetralogy of Fallot Repair
    Radiological Society of North America (RSNA) ; 2002
    In:  Radiology Vol. 223, No. 1 ( 2002-04), p. 204-211
    Details
    In: Radiology, Radiological Society of North America (RSNA), Vol. 223, No. 1 ( 2002-04), p. 204-211
    Type of Medium: Online Resource
    ISSN: 0033-8419 , 1527-1315
    URL: Article
    DOI: 10.1148/radiol.2231010924
    RVK:
    XA 10000
    Language: English
    Publisher: Radiological Society of North America (RSNA)
    Publication Date: 2002
    detail.hit.zdb_id: 80324-8
    detail.hit.zdb_id: 2010588-5
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  • 8
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    Risk of Clinically Relevant Pericardial Effusion After Pediatric Cardiac Surgery
    Springer Science and Business Media LLC ; 2019
    In:  Pediatric Cardiology Vol. 40, No. 3 ( 2019-3), p. 585-594
    Details
    In: Pediatric Cardiology, Springer Science and Business Media LLC, Vol. 40, No. 3 ( 2019-3), p. 585-594
    Type of Medium: Online Resource
    ISSN: 0172-0643 , 1432-1971
    URL: Article
    DOI: 10.1007/s00246-018-2031-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 1463000-X
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  • 9
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    Disproportionate intraventricular viscous energy loss in Fontan patients: analysis by 4D flow MRI
    Oxford University Press (OUP) ; 2019
    In:  European Heart Journal - Cardiovascular Imaging Vol. 20, No. 3 ( 2019-03-01), p. 323-333
    Details
    In: European Heart Journal - Cardiovascular Imaging, Oxford University Press (OUP), Vol. 20, No. 3 ( 2019-03-01), p. 323-333
    Type of Medium: Online Resource
    ISSN: 2047-2404 , 2047-2412
    URL: Article
    DOI: 10.1093/ehjci/jey096
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2042482-6
    detail.hit.zdb_id: 2647943-6
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  • 10
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    Hemodynamic interplay of vorticity, viscous energy loss, and kinetic energy from 4D Flow MRI and link to cardiac function in healthy subjects and Fontan patients
    American Physiological Society ; 2021
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 320, No. 4 ( 2021-04-01), p. H1687-H1698
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 320, No. 4 ( 2021-04-01), p. H1687-H1698
    Abstract: The purpose of this study was to directly assess (patho)physiology of intraventricular hemodynamic interplay between four-dimensional flow cardiovascular magnetic resonance imaging (4D Flow MRI)-derived vorticity with kinetic energy (KE) and viscous energy loss (EL) over the cardiac cycle and their association to ejection fraction (EF) and stroke volume (SV). Fifteen healthy subjects and thirty Fontan patients underwent whole heart 4D Flow MRI. Ventricular vorticity, KE, and EL were computed over systole (vorticity_vol avg systole , KE avg systole , and EL avg systole ) and diastole (vorticity_vol avg diastole , KE avg diastole , and EL avg diastole ). The association between vorticity_vol and KE and EL was tested by Spearman correlation. Fontan patients were grouped to normal and impaired EF groups. A significant correlation was found between SV and vorticity in healthy subjects (systolic: ρ = 0.84, P 〈 0.001; diastolic: ρ = 0.81, P 〈 0.001) and in Fontan patients (systolic: ρ = 0.61, P 〈 0.001; diastolic: ρ = 0.54, P = 0.002). Healthy subjects showed positive correlation between vorticity_vol versus KE (systole: ρ = 0.96, P 〈 0.001; diastole: ρ = 0.90, P 〈 0.001) and EL (systole: ρ = 0.85, P 〈 0.001; diastole: ρ = 0.84, P 〈 0.001). Fontan patients showed significantly elevated vorticity_vol compared with healthy subjects (vorticity_vol avg systole : 3.1 [2.3–3.9] vs. 1.7 [1.3–2.4] L/s, P 〈 0.001; vorticity_vol avg diastole : 3.1 [2.0–3.7] vs. 2.1 [1.6–2.8] L/s, P = 0.002). This elevated vorticity in Fontan patients showed strong association with KE (systole: ρ = 0.91, P 〈 0.001; diastole: ρ = 0.85, P 〈 0.001) and EL (systole: ρ = 0.82, P 〈 0.001; diastole: ρ = 0.89, P 〈 0.001). Fontan patients with normal EF showed significantly higher vorticity_vol avg systole and EL avg systole , but significantly decreased KE avg diastole , in the presence of normal SV, compared with healthy subjects. Healthy subjects show strong physiological hemodynamic interplay between vorticity with KE and EL. Fontan patients demonstrate a pathophysiological hemodynamic interplay characterized by correlation of elevated vorticity with KE and EL in the presence of maintained normal stroke volume. Altered vorticity and energetic hemodynamics are found in the presence of normal EF in Fontan patients. NEW & NOTEWORTHY Physiologic intraventricular hemodynamic interplay/coupling is present in the healthy left ventricle between vorticity versus viscous energy loss and kinetic energy from four-dimensional flow cardiovascular magnetic resonance imaging (4D Flow MRI). Conversely, Fontan patients present compensatory pathophysiologic hemodynamic coupling by an increase in intraventricular vorticity that positively correlates to viscous energy loss and kinetic energy levels in the presence of maintained normal stroke volume. Altered vorticity and energetics are found in the presence of normal ejection fraction in Fontan patients.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.00806.2020
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2021
    detail.hit.zdb_id: 1477308-9
    SSG: 12
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