In:
Future Cardiology, Future Medicine Ltd, Vol. 13, No. 2 ( 2017-03), p. 143-151
Abstract:
Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.
Type of Medium:
Online Resource
ISSN:
1479-6678
,
1744-8298
DOI:
10.2217/fca-2016-0046
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2017
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