In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-06-03)
Abstract:
Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor Tfcp2l1 coordinates IC and PC development. Tfcp2l1 induces the expression of IC specific genes, including specific H+-ATPase subunits and Jag1. Jag1 in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. Tfcp2l1 inactivation deletes ICs, whereas Jag1 inactivation results in the forfeiture of discrete IC and PC identities. Thus, Tfcp2l1 is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, Tfcp2l1 regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.24265.001
DOI:
10.7554/eLife.24265.002
DOI:
10.7554/eLife.24265.003
DOI:
10.7554/eLife.24265.004
DOI:
10.7554/eLife.24265.005
DOI:
10.7554/eLife.24265.006
DOI:
10.7554/eLife.24265.007
DOI:
10.7554/eLife.24265.008
DOI:
10.7554/eLife.24265.009
DOI:
10.7554/eLife.24265.010
DOI:
10.7554/eLife.24265.011
DOI:
10.7554/eLife.24265.012
DOI:
10.7554/eLife.24265.013
DOI:
10.7554/eLife.24265.014
DOI:
10.7554/eLife.24265.015
DOI:
10.7554/eLife.24265.016
DOI:
10.7554/eLife.24265.017
DOI:
10.7554/eLife.24265.018
DOI:
10.7554/eLife.24265.019
DOI:
10.7554/eLife.24265.020
DOI:
10.7554/eLife.24265.021
DOI:
10.7554/eLife.24265.022
DOI:
10.7554/eLife.24265.023
DOI:
10.7554/eLife.24265.024
DOI:
10.7554/eLife.24265.025
DOI:
10.7554/eLife.24265.026
DOI:
10.7554/eLife.24265.027
DOI:
10.7554/eLife.24265.028
DOI:
10.7554/eLife.24265.029
DOI:
10.7554/eLife.24265.043
DOI:
10.7554/eLife.24265.044
DOI:
10.7554/eLife.24265.030
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
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