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  • 1
    Online Resource
    Online Resource
    Giant uterine leiomyoma causing acute symptoms
    Akademiai Kiado Zrt. ; 2013
    In:  Orvosi Hetilap Vol. 154, No. 10 ( 2013-03), p. 387-390
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 154, No. 10 ( 2013-03), p. 387-390
    Abstract: The case history of a 71-year-old woman with acute dyspnoea caused by a giant leiomyoma and severe acute anemia due to intratumoral hemorrhage is presented. Urgent operation was performed, and a 13.5 kg pendular tumor was removed. The cornerstones of the differential diagnoses and therapy of giant abdominal tumors is discussed. Orv. Hetil., 2013, 154, 387–390.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/OH.2013.29563
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2013
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  • 2
    Online Resource
    Online Resource
    Kezdeti tapasztalataink a petefészekszövet-fagyasztás bevezetésével
    Akademiai Kiado Zrt. ; 2016
    In:  Orvosi Hetilap Vol. 157, No. 49 ( 2016-12), p. 1947-1954
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 157, No. 49 ( 2016-12), p. 1947-1954
    Abstract: Introduction: The oncological treatment may damage ovarian function. To prevent this, it is possible to cryopreserve the ovarian tissue, and to keep the samples for long-term storage. The frozen-thawed tissue could be retransplanted after chemo- or radiotherapy. Aim: The aim of our study was to examine the effect of cryopreservation on the viability of ovarian tissue. Method: We analyzed the survival of frozen-thawed donated ovarian tissues. The quality of the follicles and hormone production in fresh and frozen-thawed samples were compared. Results: Histological analysis showed that the number of viable follicles was reduced by 23% in the frozen-thawed samples. However, viable follicles still presented in post thawing ovarian tissues. Maximal estradiol production in frozen-thawed tissues was 908 pg/ml and hormone production was similar to the control tissues. The maximal progesterone production was 1.95 ng/ml post thawing, but these values were lower than the progesterone production of fresh tissues. Conclusions: The method of ovarian cryopreservation used in our laboratory was able preserve the viability of follicles in frozen-thawed ovarian tissues. Orv. Hetil., 2016, 157(49), 1947–1954.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2016.30582
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2016
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  • 3
    Online Resource
    Online Resource
    Lysophosphatidic acid as a potential target for treatment and molecular diagnosis of epithelial ovarian cancers
    Akademiai Kiado Zrt. ; 2009
    In:  Orvosi Hetilap Vol. 150, No. 24 ( 2009-06-1), p. 1109-1118
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 150, No. 24 ( 2009-06-1), p. 1109-1118
    Abstract: Az ováriumtumorok mortalitása a legmagasabb a nőgyógyászati tumorok között. Ez egyrészt a késői diagnózisnak, másrészt a hatásos terápia hiányának következménye. Az ováriumtumorok karcinogenezise és metasztázisképzése egy komplikált genetikai, molekuláris és biokémiai folyamatsor eredménye. A lizofoszfátsav (LPA) termelésének, receptorstátusának és szignáltranszdukciós útvonalának abnormalitása gyakran megtalálható az ováriumtumorokban, ami azt sejteti, hogy az LPA nagyon fontos szerepet játszik ennek a betegségnek a kialakulásában és patofiziológiájában. Így jogosan feltételezhetjük, hogy az LPA-szignálkaszkád számos célpontot szolgáltat a molekuláris kezelési módok kialakítására és jó példát mutat arra, hogyan lehet új diagnosztikus és terápiás módszereket kialakítani egyes betegségek ellen. Az LPA-t lebontó és termelő enzimcsaládoknak csak a közelmúltban történt felfedezése és a receptorspecifikus molekulák kifejlesztése új fejezetet nyithat e potenciálisan halálos betegség kezelésében. Ebben az összefoglaló tanulmányban ismertetjük, hogy a tumorsejtekben lévő LPA-t lebontó enzimek aktivitása csökkent, és ez hozzájárul a tumor progressziójához. Ugyanezen enzimek mesterségesen létrehozott, fokozott aktivitása csökkenti a tumorsejtek növekedését és elősegíti a fiziológiás viszonyok helyreállását. Bemutatjuk azokat az irodalmi adatokat, amelyek egyértelműen bizonyítják, hogy a lipidfoszfát-foszfatáz enzimek hatásukat a sejten kívüli LPA lebontásával érik el. Minthogy ez a lebontás extracellulárisan történik, ez megmagyarázza a „bystander-effect” előfordulását, amit szintén ismertetünk. Az LPA-lebontás és -termelés enzimjei, illetve az LPA-t kötő receptorok kitűnő célpontok új molekuláris terápia kidolgozására. A különböző LPA-izoformák és más lizofoszfolipidek szintváltozásainak korai detektálása segíthet a tumor korai diagnosztizálásában, illetve később a kezelés hatékonyságának követésében. A közelmúlt jelentős LPA-szignálkaszkáddal kapcsolatos kutatási eredményei azt sejtetik, hogy azok jelentős szerepet fognak játszani ennek a még mindig halálos betegségnek a kezelésében, de további kutatások szükségesek a részletek pontos megértéséhez.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/oh.2009.28631
    Language: Unknown
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2009
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  • 4
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    Online Resource
    Az ovarialis hiperstimulációs szindróma kórélettana és korszerű klinikuma
    Akademiai Kiado Zrt. ; 2018
    In:  Orvosi Hetilap Vol. 159, No. 34 ( 2018-08), p. 1390-1398
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 159, No. 34 ( 2018-08), p. 1390-1398
    Abstract: Abstract: During assisted reproduction technologies, controlled hyperstimulation of the ovaries occurs. Ovarian hyperstimulation syndrome is an excessive overreaction of the ovaries complicating pharmacological ovulation induction. Rarely other causes, such as the mutation of the follicle-stimulating hormone receptor may also be in the background. Ovarian hyperstimulation syndrome is clinically characterized by a massive ovarian enlargement associated with an acute third-space fluid shift responsible for the development of ascites, and sometimes pleural or pericardial effusion. Associated arterial or venous thromboembolic symptoms are also common. Ovarian hyperstimulation syndrome is an iatrogenic and potentially life-threatening condition in the form of ischemic stroke or circulatory insufficiency of the limbs. Recently some new methods have been developed for the prevention of the disease. The syndrome affects young, healthy patients. It also has an important economic burden due to the absence from work, bed rest, or hospitalization and intensive medical management of more severe cases. Supportive therapy, anticoagulant prophylaxis and close monitoring are the main approach for the syndrome. However, hospitalization or intervention should not be delayed for patients with severe or critical conditions. Orv Hetil. 2018; 159(34): 1390–1398.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2018.31152
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2018
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  • 5
    Online Resource
    Online Resource
    Increased Total Scavenger Capacity and Decreased Liver Fat Content in Rats Fed Dehydroepiandrosterone and Its Sulphate on a High-Fat Diet
    S. Karger AG ; 2011
    In:  Gerontology Vol. 57, No. 4 ( 2011), p. 343-349
    Details
    In: Gerontology, S. Karger AG, Vol. 57, No. 4 ( 2011), p. 343-349
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Weak androgens have an antioxidant effect in vitro which is represented as a beneficial change in the antioxidant status. 〈 i 〉 Objective: 〈 /i 〉 Our aim was to clarify whether dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) oral administration results in beneficial antioxidant changes in Sprague-Dawley adult male rats in vivo. 〈 i 〉 Methods: 〈 /i 〉 Groups of experimental animals were fed a high-fat or a normal-fat diet and treated with DHEA or DHEAS in the drinking fluid. The control group was fed a high-fat diet together with untreated drinking fluid. Total scavenger capacity (TSC) was measured before and after 4 weeks of treatment in blood samples using a chemiluminometric assay. Fat content, superoxide dismutase (SOD), catalase and glutathione S-transferase (GST) activity in the liver were determined by Sudan staining and spectrophotometric assessments, respectively, from the fresh frozen tissue. 〈 i 〉 Results: 〈 /i 〉 DHEA and the DHEAS treatment showed significantly increased TSC in the groups fed a high-fat diet. The control group and the DHEA- or DHEAS-treated groups on normal diets showed no significant changes in TSC. The total score of liver fat content in the high-fat diet groups showed a marked positivity with Sudan staining, and the groups treated with DHEA or DHEAS had a markedly decreased amount of fat in the liver slides compared to the untreated group on the high-fat diet. Liver SOD activity was decreased in all high-fat diet groups and elevated only in the groups on a normal diet with DHEA or DHEAS treatment. Liver catalase and GST activities were decreased in the groups where TSC was significantly increased. 〈 i 〉 Conclusion: 〈 /i 〉 Our results support the hypothesis that DHEA and DHEAS supplementation can improve the antioxidant status in lipid-rich dietary habits.
    Type of Medium: Online Resource
    ISSN: 0304-324X , 1423-0003
    URL: Article
    DOI: 10.1159/000321385
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1482689-6
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  • 6
    Online Resource
    Online Resource
    Association between Estrogen Receptor .ALPHA. (ESR1) Gene Polymorphisms and Severe Preeclampsia
    Japanese Society of Hypertension ; 2007
    In:  Hypertension Research Vol. 30, No. 3 ( 2007), p. 205-211
    Details
    In: Hypertension Research, Japanese Society of Hypertension, Vol. 30, No. 3 ( 2007), p. 205-211
    Type of Medium: Online Resource
    ISSN: 0916-9636 , 1348-4214
    URL: Article
    DOI: 10.1291/hypres.30.205
    Language: English
    Publisher: Japanese Society of Hypertension
    Publication Date: 2007
    detail.hit.zdb_id: 2110941-2
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  • 7
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    Online Resource
    Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia
    Walter de Gruyter GmbH ; 2014
    In:  Clinical Chemistry and Laboratory Medicine (CCLM) Vol. 52, No. 2 ( 2014-01-1)
    Details
    In: Clinical Chemistry and Laboratory Medicine (CCLM), Walter de Gruyter GmbH, Vol. 52, No. 2 ( 2014-01-1)
    Abstract: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in early-onset preeclampsia (EOP), late-onset preeclampsia (LOP) and healthy pregnant groups. We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n=20) and LOP group (n=20), according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. BNP levels were higher in EOP [61.35 (36.95–93.25) pg/mL] and LOP patients [32.4 (19.15–39.2) pg/mL] than in healthy pregnant women [10.05 (6.08–16.03) pg/mL] (both p 〈 0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p 〈 0.001). A BNP cut-off 〈 24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significant inverse correlation between plasma BNP levels of EOP patients and sodium (p 〈 0.05) and total protein concentrations (p 〈 0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p 〈 0.05), serum potassium (p 〈 0.05), urea (p 〈 0.05) and 24-h proteinuria (p 〈 0.05). BNP levels were significantly higher in EOP than in LOP patients. The cut-off value 〈 24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.
    Type of Medium: Online Resource
    ISSN: 1437-4331 , 1434-6621
    URL: Article
    DOI: 10.1515/cclm-2013-0307
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
    detail.hit.zdb_id: 1492732-9
    SSG: 15,3
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  • 8
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    A mikro-RNS-ek patogenetikai szerepe és expressziós mintázata praeeclampsiában
    Akademiai Kiado Zrt. ; 2018
    In:  Orvosi Hetilap Vol. 159, No. 14 ( 2018-04), p. 547-556
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 159, No. 14 ( 2018-04), p. 547-556
    Abstract: Abstract: Preeclampsia is the leading cause of maternal and fetal morbidity and mortality that affects 3–8% of pregnancies worldwide. Its main symptoms include new onset of high blood pressure and proteinuria after 20 weeks of pregnancy. The cause of the disease is still debated. microRNAs are short, non-coding RNA molecules that play a pivotal part in the posttranscriptional regulation of eukaryotic genes. They are involved in fine-tuning of vital physiological processes such as cell cycle, proliferation, differentiation and cell death. In genomic studies, hundreds of microRNAs were detected in the placenta, which are supposed to regulate placental development and contribute to uncomplicated pregnancy. Several studies have reported changes in the expression of microRNAs in pregnancy. Abnormal microRNA expression may have a role in the development of preeclampsia as it affects the proliferation, migration, and invasion of the trophoblast cells, spiral artery remodeling, and angiogenesis. Some placental microRNAs (e.g., the C19MC microRNA cluster) are able to reach the maternal circulation through their release via exosomes from the trophoblast layer. These ‘circulating’ microRNA molecules can be applied as biomarkers for the detection of various placental disorders owing to their stability and specificity. Orv Hetil. 2018; 159(14): 547–556.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2018.31025
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2018
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  • 9
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    Online Resource
    Transvaginal specimen extraction after laparoscopic bowel resection in deeply infiltrating endometriosis
    Akademiai Kiado Zrt. ; 2014
    In:  Orvosi Hetilap Vol. 155, No. 11 ( 2014-03), p. 420-423
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 155, No. 11 ( 2014-03), p. 420-423
    Abstract: The authors report a case of a 27-year-old patient who had deeply infiltrating endometriosis involving the rectum, sigmoid colon and the rectovaginal septum, which was removed by laparoscopic surgery. During surgery the affected bowel segment, the deeply infiltrating nodule of the rectovaginal septum and the posterior vaginal wall were resected and the 12 cm long specimen was removed transvaginally. Postoperative bleeding was noted in the first postoperative day, which was treated laparoscopically, aswell. This case history confirms data from the literature showing that the natural orifice specimen extraction procedure can widely be applied during operations for deeply infiltrating endometriosis and that laparoscopic anterior resection is a safe and feasible method for the treatment of colorectal deeply infiltratnig endometriosis. Moreover, perioperative complications can be treated by means of laparoscopic surgery. Orv. Hetil., 2014, 155(11), 420–423.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/OH.2014.29841
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2014
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  • 10
    Online Resource
    Online Resource
    Prospektív vizsgálat a sigmoideoscopia diagnosztikai érzékenységének meghatározására vastagbelet infiltráló endometriosisban
    Akademiai Kiado Zrt. ; 2017
    In:  Orvosi Hetilap Vol. 158, No. 7 ( 2017-02), p. 264-269
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 158, No. 7 ( 2017-02), p. 264-269
    Abstract: Abstract: Introduction and aim: In the treatment of colorectal endometriosis a multidisciplinary laparoscopic resection is suggested, for this reason the correct selection of bowel infiltration is essential before surgery. Patients and method: Between 2009 and 2015, 383 sigmoidoscopies were performed in patients with endometriosis. Where mucosal invasion was absent secondary signs (wall rigidity, impression, kinking, pain during the examination, suffusion) were analysed. In endoscopically confirmed cases multidisciplinary surgery was performed, the remaining patients were operated by a gynecologic team only. Results: Endometriosis was endoscopically confirmed in 224 patients (58.49%), 108 of them underwent multidisciplinary operation, the negative 135 cases received gynaecological surgery. Bowel endometriosis was confirmed in 103 out of 108 cases intraoperatively, while in 8 cases of the sigmoidoscopically negative patients bowel infiltration was diagnosed intraoperatively by the gynaecological team. Complete sigmoidoscopy was performed in 43.47% of the cases. Intraluminal endometriosis was found in 4.91%, secondary signs as rigidity in 38.39%, impression in 45.54%, kinking in 57.14%, pain (in cases of examination without narcosis) in 26.06% and suffusion in 3.82% of the cases was found during sigmoidoscopy. Sigmoidoscopic examination has a 92.8% specificity and 96.2% sensitivity in cases of bowel endometriosis. Conclusion: Sigmoidoscopy performed by an experienced gastroenterologist is a highly sensitive examination for the diagnosis of bowel endometriosis. Orv. Hetil., 2017, 158(7), 264–269.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2017.30663
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2017
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