In:
Journal of Parenteral and Enteral Nutrition, Wiley, Vol. 19, No. 1 ( 1995-01), p. 33-40
Abstract:
Background : This study was undertaken to determine the effect of chemically defined structured lipids on nonspecific host defense and on histologic patterns of liver and lungs compared with a physical mixture of long‐chain triglycerides and medium‐chain triglycerides in a continuous low‐dose endotoxin rat model. Methods: Forty male Sprague‐Dawley rats, divided into four feeding groups (structured lipids, structured lipids + endotoxin, physical mixture, physical mixture + endotoxin), received total parenteral nutrition for 48 hours. During the first part of the study, 24 animals were given an injection of live Escherichia coli labeled with radioactive iron ( 59 Fe) to investigate the function of the reticuloendothelial system. During the second part of the study, the liver and lungs of 16 animals were histologically examined using light and electron microscopy. Results: Despite the similar values in the control groups, the animals receiving structured lipids + endotoxin sequestered a significantly greater percentage of bacteria in the liver and spleen ( p ≤.01) and a significantly lesser percentage in the lung ( p ≤.05) compared with the animals given physical mixture + endotoxin as part of their diet. Moreover, rats in the physical mixture + endotoxin group showed a microscopically evaluated higher fatty infiltration in the liver than did the structured lipids + endotoxin group. Conclusions : The results of this study indicate that chemically defined structured lipids reduce fatty infiltration of the liver compared with a physical mixture of the same compounds in an animal model of metabolic stress. They were accompanied by a better function of the reticuloendothelial system and a lesser bacterial sequestration in the lungs. (Journal of Parenteral and Enteral Nutrition 19 :33–40, 1995)
Type of Medium:
Online Resource
ISSN:
0148-6071
,
1941-2444
DOI:
10.1177/014860719501900133
Language:
English
Publisher:
Wiley
Publication Date:
1995
detail.hit.zdb_id:
2170060-6
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