In:
Hormone Research in Paediatrics, S. Karger AG, Vol. 79, No. 1 ( 2013), p. 9-16
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Endocrine complications after acute lymphoblastic leukemia (ALL) are common. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Final height, GH/IGF-1 axis, and body mass index were analyzed after 13.7 (7.0–20.7) years from diagnosis in 34 boys aged 〈 12 years at diagnosis and 41 girls 〈 10 years at diagnosis. A modified German BFM-83 ALL protocol included (n = 42) or did not include (n = 33) prophylactic cranial irradiation. In 27 patients, GH after insulin tolerance test, IGF-1, cortisol, free T 〈 sub 〉 4 〈 /sub 〉 and estradiol/testosterone were determined. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Final height was significantly reduced (mean Z-score for height between final height and diagnosis, ΔHAZ = –0.61, p = 0.0001). At that point, 3 patients were obese (4%) and 17 were overweight (22.7%). Patients aged ≤4 years at diagnosis and those irradiated had a greater loss in final height (p = 0.001 and p = 0.008, respectively). Abnormalities in GH/IGF-1 axis were observed in 4 patients: 3 had a GH peak 〈 6 ng/ml and 1 had a serum IGF-1 concentration 〈 25 ng/ml. Growth deficit was significantly higher in patients with hormonal deficiency (p = 0.006). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Treatment of ALL during childhood is associated with final height deficit. Young age at diagnosis and radiotherapy were the major risk factors. GH/IGF-1 deficiency was found particularly in irradiated patients, even though it was detected in 1 non-irradiated patient.
Type of Medium:
Online Resource
ISSN:
1663-2818
,
1663-2826
Language:
English
Publisher:
S. Karger AG
Publication Date:
2013
detail.hit.zdb_id:
2540224-9
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