In:
Scandinavian Journal of Immunology, Wiley, Vol. 65, No. 3 ( 2007-03), p. 271-275
Abstract:
Dysregulation of the Notch‐pathway has been implicated in the pathogenesis of chronic lymphocytic leukaemia (B‐CLL). We characterized the mRNA expression of Notch pathway elements in circulating normal B‐ and B‐CLL cells, and compared expression profiles with clinical and prognostic data. Similar expression profiles were found in normal B‐cells and B‐CLL cells, however, most B‐CLL samples showed lower Hairy/Enhancer of Split‐1 expression than normal B‐cells, which suggests that the pathway is not over‐activated in B‐CLL. The expression of Notch‐pathway genes did not correlate with other prognostic factors of B‐CLL. The importance of Notch‐signalling in CLL cells in lymphatic tissue microenvironments remains to be determined.
Type of Medium:
Online Resource
ISSN:
0300-9475
,
1365-3083
DOI:
10.1111/sji.2007.65.issue-3
DOI:
10.1111/j.1365-3083.2006.01897.x
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2020954-X
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