In:
Acta Crystallographica Section B Structural Science, International Union of Crystallography (IUCr), Vol. 65, No. 3 ( 2009-06-01), p. 375-381
Abstract:
Examination of the symmetric Hantzsch 1,4-dihydropyridine ester derivatives of the prototypical nifedipine molecule indicates the tendency of this class of molecule to form a common packing motif. Crystal structure analysis of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic diesters and analogs reveals that they form extended chains, characterized as the C (6) packing motif, via intermolecular (amine) N—H...O=C (C3,C5 carbonyl) hydrogen bonds. In addition, all the prepared derivatives also satisfy the basic structural requirements for their high binding efficiency to the receptor. The reproducible C (6) packing motif observed among these compounds has a use in the design of solid-state materials.
Type of Medium:
Online Resource
ISSN:
0108-7681
DOI:
10.1107/S0108768109004832
DOI:
10.1107/S0108768109004832/eb5001sup1.cif
DOI:
10.1107/S0108768109004832/eb5001Isup2.fcf
DOI:
10.1107/S0108768109004832/eb5001IIsup3.fcf
DOI:
10.1107/S0108768109004832/eb5001IIIsup4.fcf
DOI:
10.1107/S0108768109004832/eb5001IVsup5.fcf
DOI:
10.1107/S0108768109004832/eb5001sup6.pdf
Language:
Unknown
Publisher:
International Union of Crystallography (IUCr)
Publication Date:
2009
detail.hit.zdb_id:
2020841-8
SSG:
13
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