In:
Archives of Insect Biochemistry and Physiology, Wiley, Vol. 20, No. 2 ( 1992-01), p. 145-155
Abstract:
Allatotropin (AT) is a 13 amino acid neuropeptide isolated from the tobacco hornworm, Manduca sexta , which stimulates the biosynthesis of juvenile hormone (JH) in adult females of this insect. In this paper we report that AT stimulates inositol phosphate formation in both female and male corpora allata (CA) of adult Manduca sexta . Furthermore, thapsigargin, a potent Ca 2+ ‐ATPase inhibitor, staurosporine, a potent inhibitor of protein kinases A and C, and 2,5‐di‐(tert‐butyl)‐1,4‐hydroquinone (DBHQ), a potent inhibitor of liver microsomal ATP‐dependent Ca 2+ sequestration, all stimulate JH biosynthesis without changing the basal level of inositol phosphates. These data suggest that AT activates an inositol 1,4,5‐trisphosphate (IP 3 ) pathway. Furthermore, increases in the free intracellular Ca 2+ concentration in the CA stimulate JH biosynthesis. © 1992 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0739-4462
,
1520-6327
DOI:
10.1002/arch.940200206
Language:
English
Publisher:
Wiley
Publication Date:
1992
detail.hit.zdb_id:
1496071-0
detail.hit.zdb_id:
11323-2
SSG:
12
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