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  • 1
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    Online Resource
    Abstract TP30: Effect of General Anesthesia versus Conscious Sedation on Achievement of Substantial Reperfusion for Different Target Occlusions - Analysis of the Goliath Randomized Trial
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Stroke Vol. 51, No. Suppl_1 ( 2020-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 51, No. Suppl_1 ( 2020-02)
    Abstract: Background: Achievement of successful reperfusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) may affected by patient motion, especially in more difficult to access, technically challenging targets, such as tandem and distal occlusions. General anesthesia (GA) may be particularly beneficial as compared to conscious sedation (CS) in such patients. Methods: We evaluated target occlusion subtypes in the GOLIATH randomized trial comparing GA and CS. Patients were divided in 2 groups based on target arterial occlusion: 1) single, proximal occlusion (ICA T/M1), and 2) tandem or distal (M2) occlusion. Technical success was defined as substantial reperfusion (TICI 2B/3). Clinical outcome measures at 90 days included disability level (mRS ordinal), functional independence (mRS 0-2), and mortality. Multivariable analysis adjusted for age, baseline NIHSS, baseline ischemic core volume, and IV TPA was conducted in each group to assess the impact on technical and clinical outcome. Interaction test for heterogeneity was conducted to assess the difference in outcomes across the subrgoups. Results: Among 128 analyzed patients, 80 (62.5%) had single, proximal occlusions and 48 (37.5%) had tandem (22.7%) or distal (14.8%). The absolute difference in substantial reperfusion was higher for both tandem occlusion (83.3% vs 36.4%) and distal occlusion (75% vs 57.1%) than for single, proximal occlusion (74.3% vs 66.7%). The combined distal and tandem occlusion group showed magnified reperfusion success with GA vs CS (80.0% vs 44.4%) compared with the single, proximal occlusion group, (p=0.048, interaction test for heterogeneity). The single and proximal occlusion group showed improved 3m functional independence with GA vs PS (p=0.030), although the heterogeneity between groups was not significant (proximal and single: 71.4% vs 44.4%; tandem or distal: 63.3% vs 72.2%, heterogeneity p=0.12). There was no heterogeneity in the effect of method of sedation on mortality across analyzed groups. Conclusions: Achievement of substantial reperfusion during endovascular thrombectomy may differentially be aided by general anesthesia in patients with technically more challenging distal and tandem occlusions
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.51.suppl_1.TP30
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 2
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    Abstract P575: Impaired Distal Perfusion Predicts In-Hospital Outcome in Patients With Symptomatic Middle Cerebral Artery Stenosis
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Stroke Vol. 52, No. Suppl_1 ( 2021-03)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. Suppl_1 ( 2021-03)
    Abstract: Background: Perfusion imaging is increasingly used to risk stratify patients with symptomatic intracranial stenosis. Length of hospital stay (LOS) in patients with ischemic stroke is a surrogate marker of increased morbidity. We aim to determine the association between perfusion delay on T max ( 〈 4 sec, 4-6 sec, and 〉 6 sec) on perfusion weighted imaging and LOS in patients with symptomatic middle cerebral artery (MCA) stenosis. Methods: We included consecutive patients with left MCA stenosis admitted with ischemic stroke or TIA 〈 7 days from onset who underwent perfusion imaging (CT or MR perfusion) processed with RAPID software. We excluded patients with core infarct ≥ 30 mL. Perfusion mismatch was divided into three groups: mismatch volume ≥ 15 mL based on T max 〉 6 sec delay, mismatch volume ≥ 15 mL based on T max 4-6 sec delay, and neither of the above mismatch patterns. The primary outcome was LOS, both as a continuous variable and categorical (≥ 7 days (prolonged LOS) vs. 〈 7 days). Results: 179 out of 194 patients met the inclusion criteria; mean age was 70.2 ± 15.4 years, 53.1% were women, median (IQR) NIHSS was 4 (1-9); 83.2% underwent MR perfusion; 38.5% had a mismatch volume ≥ 15 mL based on T max 〉 6 sec and 31.3% had a mismatch volume ≥ 15 mL based on T max 4-6 sec and the median (IQR) LOS was 4 days (2-8). After adjusting for age and NIHSS, T max 〉 6 sec mismatch definition was associated with prolonged LOS (OR 2.90 95% CI 1.06-8.18; p=0.039) but T max 4-6 sec definition was not (OR 1.45 95% CI 0.46-4.58, p=0.528), without any interaction based on perfusion imaging modality (p interaction = 0.568). We found similar associations when LOS was considered as a continuous variable for T max 〉 6 sec (β coefficient=2.01, 95% CI 0.05-3.97, p=0.044) and T max 4-6 sec (β coefficient=1.24, 95% CI -0.85-3.34, p=0.244). In receiver operating curves, the optimal mismatch volume for T max 〉 6 sec was 10 mL (sensitivity 0.61 and specificity 0.63) whereas for T max 4-6 sec it was 39 mL (sensitivity 0.61 specificity 0.56). Conclusion: In patients with recently symptomatic MCA stenosis, the T max 〉 6 sec definition for mismatch, but not T max 4-6 sec, is associated with prolonged LOS. Prospective studies are needed to validate our findings and define the optimal mismatch threshold in patients with symptomatic MCA stenosis.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.52.suppl_1.P575
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
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  • 3
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    Abstract 170: Impact of Eloquent Motor Cortex-Tissue Reperfusion Beyond the Traditional TICI Scoring After Thrombectomy
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Stroke Vol. 51, No. Suppl_1 ( 2020-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 51, No. Suppl_1 ( 2020-02)
    Abstract: Background: Targeted eloquence-based tissue reperfusion within the primary motor cortex may have differential effect on disability as compared to the traditional volume-based (TICI) reperfusion after endovascular thrombectomy (EVT) in setting of acute ischemic stroke (AIS). Methods: We explored the impact of eloquent reperfusion (ER) within primary motor cortex (PMC) on clinical outcome (mRS) in AIS patients undergoing EVT. ER was defined as presence of flow on final digital subtraction angiography (DSA) within four main cortical branches, supplying the PMC (MCA - precentral, central, anterior parietal; ACA- pericallosal) and graded as absent (0), partial (1), and complete (2). Prospectively collected data from two centers were analyzed. Multivariable analysis was conducted to assess the impact of ER on 90-day disability (mRS) among patients with anterior circulation occlusion who achieved partial reperfusion (TICI 2 a and b). Results: Among the 125 patients who met study criteria, median age was 73, median NIHSS was 16, median ASPECTS was 7, 48% (60/125) were female, and 36.8% achieved functional independence (mRS 0-2) at 90 days. ER distribution was: Absent (0) in 19/125 (15.2%); Partial (1) in 52/125 (41.6%), and Complete (2) in 54/125 (43.2%). TICI 2b was achieved in 102/125 (81.6%) and ER was substantially higher in those patients (p 〈 0.001). In multivariate analysis, in addition to age and sICH, ER had a profound independent impact on 90-day disability (OR 6.10, p=0.001 for ER 1 vs 0; and OR 9.87, p 〈 0.001 for ER 2 vs 0). In contrast, extent of total partial reperfusion (TICI 2b vs 2a) was not related to 90-day disability. Conclusions: Our findings support that eloquent PMC-tissue reperfusion is a major determinant of functional outcome, more impactful than volume-based degree of partial reperfusion. More aggressive, PMC-targeted revascularization among patients with non-eloquent partial reperfusion may further improve post-stroke disability after EVT.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.51.suppl_1.170
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 4
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    Abstract 151: Physiologic Predictors of Collateral Circulation and Infarct Growth in Setting of Anesthesia During Thrombectomy: Detailed Analysis of the GOLIATH Trial
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Stroke Vol. 50, No. Suppl_1 ( 2019-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. Suppl_1 ( 2019-02)
    Abstract: Introduction: Collateral circulation plays a pivotal role in acute ischemic stroke due to large vessel occlusion and may be affected by multiple variables during sedation for endovascular therapy (EVT). Identification of potentially modifiable physiologic predictors of collateral circulation will help to refine the most optimal anesthetic strategy in clinical practice and future trials. Methods: We conducted detailed analyses of the GOLIATH database to identify 1) predictors of collateral circulation grade and 2) infarct growth at 24h. Angiographic collaterals immediately prior EVT were graded by two investigators, followed by consensus adjudication. We also modified the ASITN collateral scale by dividing grade 2 in two separate categories: 2- (persistent filling defect in 〉 50% of the ischemic territory) and 2+ ( 〈 50% of the territory) and sought to determine its impact on clinical outcome and 24h infarct growth. Multivariable analysis was used to identify predictors of collaterals and infarct growth. Results: Collaterals were evaluable in 62% (80/128) of analyzed patients, including grades 1 (n=9), 2- (n=19), 2+ (n=31), 3 (n=21). Ordinal analysis demonstrated nominal, but non-significant association between modified ASITN scale and infarct growth (figure 1). There was no correlation between collaterals and outcome. Among all analyzed variables [Age, NIHSS, ASPECTS, HTN, DM, time to groin, end tidal CO2 levels, general anesthesia, Propofol dose, Phenylephrine dose, mean arterial pressure (MAP) drop 〈 70 mmhg ], the most significant predictor of infarct growth at 24h was Phenylephrine dose (beta 6.13; p=0.026), and the most significant predictor of collateral grade was MAP 〈 70 mmhg (OR 0.34; p = 0.044). Conclusions: ASITN grade 2-/+ may be useful as distinct categories for collateral grading. Higher phenylephrine dose is a strong predictor of infarct growth, while lower MAP strongly correlates with worse angiographic collaterals during sedation for EVT.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.50.suppl_1.151
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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  • 5
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    Abstract P122: The Impact of Center Certification Status on Acute Stroke Care Within a Multi-Hospital System in Western United States
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Stroke Vol. 52, No. Suppl_1 ( 2021-03)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. Suppl_1 ( 2021-03)
    Abstract: Introduction: We aimed to investigate the impact of certification status on process of care metrics and clinical outcome in a large multi-center hospital system. Methods: We analyzed data obtained from the Providence Stroke Registry between January 2016 and December 2019. Key process of care metrics and clinical outcome were compared among patients with a discharge diagnosis of stroke and stratified based on site certification: comprehensive stroke center (CSC), thrombectomy-capable stroke center (TSC), primary stroke center (PSC) and no certification (NC). Donner’s adjusted chi-square tests were used to compare proportions for each metric grouped by certification. Generalized linear mixed effects logistic regression models were used to adjust for mode of patient arrival, age, sex, admit NIHSS, and medical history. Results: Data included 45,278 patients. Results from the analyses are summarized in the table. Donner’s adjusted chi-square analyses showed significant differences for metrics across certification groups. Results from the logistic regression models indicated significant differences in IV TPA and EVT treatment, as well as IV TPA treatment times across certification groups. There were no significant differences between TSC and CSC. Conclusions: Patients presenting with acute ischemic stroke at NC and PSC were significantly less likely to receive IV TPA or EVT with significantly less efficient IV tPA treatment times as compared to CSC. However, CSC and TSC sites performed similarly.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.52.suppl_1.P122
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
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  • 6
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    Evolution of a US County System for Acute Comprehensive Stroke Care
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. 5 ( 2018-05), p. 1217-1222
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. 5 ( 2018-05), p. 1217-1222
    Abstract: In Orange County, California, patients with suspected acute stroke are taken to stroke neurology receiving centers that are designated by County Emergency Medical Services authorities as either hubs or spokes based on endovascular treatment capability. We examined relationships between stroke details, reperfusion therapies, hospital transfers, and their change over time. Methods— All patients from January 1, 2013, to December 31, 2015, for whom 911 was called within 7 hours of onset in whom Emergency Medical Services personnel suspected acute stroke were evaluated. Results— Among 6132 patients, 3924 (64%) had confirmed diagnosis of stroke (74% ischemic/26% hemorrhagic), yielding diagnostic precision of 64% in the field. Of the 2892 patients with acute ischemic stroke, acute reperfusion therapy was given to 29.2% (21.7% intravenous tPA [tissue-type plasminogen activator] only and 7.5% endovascular treatment). Rates of endovascular treatment of patients with ischemic stroke increased over time, more than doubling from 5.6% in 2013 to 12.5% (odds ratio per 3-month quarter=1.09; 95% confidence interval, 1.04–1.14; P 〈 0.0001). Only 3.4% of patients with acute ischemic stroke were transferred from a spoke to a hub hospital; transfer rates were inversely related to age ( P 〈 0.0001), and reperfusion therapy rates did not vary according to transfer status. Conclusions— Favorable features of this acute stroke care system include reperfusion therapy in 29.2% of patients with ischemic stroke and substantial increases in endovascular treatment rates over time. Continued efforts to optimize acute stroke systems of care can be directed toward improving access to best acute stroke therapies.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.118.020620
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
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  • 7
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    Abstract WP273: Evolution of a U.S. County System for Acute Comprehensive Stroke Care
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Stroke Vol. 48, No. suppl_1 ( 2017-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 48, No. suppl_1 ( 2017-02)
    Abstract: Introduction: In an effort to maximize provision of acute stroke therapies, the Emergency Medical Services (EMS) in Orange County, CA (6 th most populous U.S. county) established a system of care whereby patients with suspected acute stroke are taken to hub sites with endovascular treatment (EVT) capability or to spoke hospitals. Patients at spokes with acute ischemic stroke (AIS) and suspected large vessel occlusion (LVO) are transferred by EMS to hubs. Here we examined the relationship between stroke features, hospital transfers, and mortality; and their change over time. Methods: All patients during 2013-2015 were included for whom 911 was called within 7 hours of onset, and EMS personnel declared “acute stroke" at end of initial evaluation. Results: A total of 6,188 patients (mean age 72) had suspected stroke, of which 54.9% were AIS and 19.4% hemorrhagic stroke. Across all patients, transfer rates into hub sites increased over time (OR 1.12 per 3-months, p 〈 0.0001) and differed by diagnosis (p 〈 0.0001), with transfer in 12.0% of hemorrhages (n=122) but only 3.5% of AIS (n=101). Among patients with AIS only, transfer rates into a hub site increased over time (OR 1.08, p 〈 0.0001), spiking mid-2015. Acute reperfusion therapy was given to 28.3% (20.9% IV tPA only, 3.6% IA therapy only, 3.8% IV tPA+IA), but its usage was unrelated to transfer status, and only 11% of all transferred AIS patients received EVT. Across all patients, mortality during acute hospitalization was 8.2% and did not differ by transfer status, but did differ by diagnosis (p 〈 0.0001): 23.6% of hemorrhages vs. 5.4% of AIS. Over time, mortality decreased only among patients with AIS (OR 0.95, p=0.03). Conclusions: There were several favorable features of this acute stroke care system, including that 28.3% of AIS patients received reperfusion therapy and that mortality decreased over time. However, while transfer to EVT-ready sites increased, rates of IA therapy were low. Continued efforts to optimize acute stroke systems of care should be tailored toward increasing EVT by early recognition of LVO and timely triage to hub facilities.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.48.suppl_1.wp273
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
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  • 8
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    Abstract WMP120: Development Of Smartphone Enabled Machine Learning Algorithms For Autonomous Stroke Detection
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Stroke Vol. 54, No. Suppl_1 ( 2023-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. Suppl_1 ( 2023-02)
    Abstract: Background: We developed an automated smart phone application for detection of acute stroke using machine learning (ML) algorithms for recognition of facial asymmetry, arm weakness, and speech changes. Methods: We analysed prospectively collected data from patients admitted to 4 major metropolitan stroke centers with confirmed diagnosis of acute stroke. Speech and facial data were captured via video recording and arm data was captured via device sensors. A. Face. This module extracts 68 facial landmark points that are passed through a dimensionality reduction step and an asymmetry classifier. We implemented and compared 26 classification methods with neurologists' clinical impression and determined Quadratic Discriminative Analysis as the best one in terms of accuracy and interpretability. B. Arm. Using data extracted from 3D accelerometer, gyroscope, and magnetometer , we designed a grasp agnostic classifier based on AdaBoost to process motion trajectories and detect arm weakness.C. Speech. We developed an algorithm based on frequency analysis and Mel Frequency Cepstral Coefficients (MFCC) to detect abnormal/slurred speech. All tests were conducted within 72 hours of admission. Each of the three ML outputs was correlated with neurologists’ clinical impression. Results: Among the 269 analysed patients, 41% were female, the median age was 71, % had hemorrhagic and % had ischemic stroke. Final analyses of 18311 facial images revealed 99.42% sensitivity, 93.67% specificity, and 97.11% accuracy in detection of facial asymmetry. The results for 43 arm trajectories revealed 71.42% sensitivity, 72.41% specificity, and 72.09% accuracy in detection of arm weakness. Preliminary analysis of MFCC algorithms confirmed adequate features for abnormal speech detection Conclusions: Our preliminary results confirm that smartphone enabled ML-algorithms can reliably identify acute stroke features with accuracy comparable to neurologists’ clinical impression.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.54.suppl_1.WMP120
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
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  • 9
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    Abstract P340: Chronic Cerebrovascular Damage and Acute Embolic Mechanisms Associated With Acute Leptomeningeal Collateral Flow in Embolic Large Vessel Occlusion
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Stroke Vol. 52, No. Suppl_1 ( 2021-03)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. Suppl_1 ( 2021-03)
    Abstract: Background and Purpose: Acute leptomeningeal collateral flow is vital to maintain blood perfusion to penumbral tissue in acute ischemic stroke due to large vessel occlusion (LVO). However, the degree of this collateral flow differs among patients. Patient premorbid factors as well as factors caused by the mechanisms of stroke are expected to be associated with this collateral flow. We aimed to investigate the clinical determinants of acute leptomeningeal collateral flow in embolic LVO. Methods: Among consecutive stroke patients caused by acute embolic anterior circulation LVO, we retrospectively reviewed 108 patients who underwent evaluation of acute leptomeningeal collateral status (CS) on pretreatment CTA admitted from January 2015 to December 2019. Both premorbid information including cerebrovascular risk factors and leukoaraiosis evaluated by the total white matter (WM) Fazekas score on MRI, which was calculated as periventricular plus deep WM scores, and stroke related information including stroke subtypes, severity, time course, and occlusive thrombus characteristics were collected. Among thrombus characteristics, thrombus length was measured by tracing the filling defect of contrast on CTA. The clinical determinants of good leptomeningeal CS ( 〉 50% collateral filling of the occluded territory) were analyzed. Results: CS was good in 67 patients (62%). On multivariate logistic regression analysis, cardioembolic stroke subtype was negatively related (OR, 0.170; 95% CI, 0.022-0.868), and mild leukoaraiosis (total WM Fazekas scores of 0-2) was positively related (OR, 9.57; 95% CI, 2.49-47.75) to good CS. On subgroup analysis limited to 82 patients with cardioembolic stroke, shorter thrombus length (OR, 0.913 per mm increase; 95% CI, 0.819-0.999) as well as mild leukoaraiosis (OR, 5.79; 95% CI, 1.40-29.61) were independently related to good CS. Conclusions: Premorbid leukoaraiosis and cardioembolic etiology are determinants of acute leptomeningeal collateral flow in embolic LVO. In addition, thrombus length is also a determinant of collateral flow in cardioembolic LVO. These findings indicate that a combination of chronic cerebrovascular damage and acute embolic mechanisms could determine the degree of leptomeningeal collateral flow.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.52.suppl_1.P340
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
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  • 10
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    Abstract 200: Collaterals in SWIFT PRIME: Imaging Correlates and Ultimate Impact
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Stroke Vol. 47, No. suppl_1 ( 2016-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 47, No. suppl_1 ( 2016-02)
    Abstract: Background: The overwhelming benefit of endovascular stroke therapy established in recent trials fueled by rapid workflow, modern devices and favorable noninvasive imaging profiles newly question the impact of collateral grade. We analyzed the SWIFT PRIME trial to evaluate the role of collaterals with respect to advanced imaging selection, the pace of infarct growth and ultimate clinical outcomes. Methods: Conventional angiography of the endovascular arm in SWIFT PRIME (n=98) was reviewed by 3 independent readers that scored ASITN/SIR collateral flow grade, followed by consensus adjudications. Angiographic collaterals were scored only when available, prior to use of the Solitaire stent retriever. Statistical analyses investigated the relationship of collateral grade with clinical and imaging variables in the main trial dataset. Results: 70 endovascular arm subjects (mean age 65.2±12.1 years, 35 (50%) women) had angiographic collaterals scored by 3 independent readers ( W =0.93). Pretreatment CT or MR perfusion imaging was obtained in 92% of cases, associated with a relatively wide range of angiographic collateral grades (1, n=6 (9%); 2, n=25 (36%); 3, n=37 (53%); 4, n=2 (3%)) with a preponderance (79%) of M1 occlusions. Worse collaterals were associated with prior myocardial infarction (33% (grade 1), 8% (grade 2), 3% (grades 3, 4); p=0.03) but unrelated to age, sex, or other co-morbidities or time from stroke onset. Baseline ASPECTS (median 9, r=0.20) trended higher (p=0.09) in those with more robust collaterals. Collaterals were unrelated to degree of TICI reperfusion, yet the presence of distal emboli at procedure end was linked with worse collaterals (p=0.008). More robust collaterals exhibited a potent and graded link with better day 90 mRS (r=- 0.3, p=0.03) and lower mean NIHSS at 27 hours (r=-0.3, p=0.03), whereas infarct growth at 27 hours was unrelated (r=-0.07, p=0.60). Conclusions: Use of advanced noninvasive perfusion imaging enrolls patients with more robust collateral grades, yet a diverse range of collaterals may be seen. Even with rapid workflow, mismatch based selection and successful reperfusion, the degree of angiographic collaterals continues to be strongly associated with clinical outcomes at all timepoints.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.47.suppl_1.200
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
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