In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 63, No. 6 ( 2019-06)
Abstract:
We compared the pharmacokinetics and efficacy of a combination of d -cycloserine (DCS) and ethionamide (ETO) via oral and inhalation routes in mice. The plasma half-life ( t 1/2 ) of oral ETO at a human-equivalent dose decreased from 4.63 ± 0.61 h to 1.64 ± 0.40 h when DCS was coadministered. The area under the concentration-time curve from 0 h to time t (AUC 0– t ) was reduced to one-third. Inhalation overcame the interaction. Inhalation, but not oral doses, reduced the lung CFU/g of Mycobacterium tuberculosis H37Rv from 6 to 3 log 10 in 4 weeks, indicating bactericidal activity.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.00099-19
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2019
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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