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  • 1
    Online Resource
    Online Resource
    Marwah Infotech ; 2021
    In:  Asian Pacific Journal of Health Sciences Vol. 8, No. 4 ( 2021-10-09), p. 79-86
    In: Asian Pacific Journal of Health Sciences, Marwah Infotech, Vol. 8, No. 4 ( 2021-10-09), p. 79-86
    Abstract: Objective: The purpose of this review is to summarize existing knowledge regarding various barriers and facilitators in the management of Type 2 diabetes from the perspective of patients. Method: A comprehensive electronic search was conducted which included three sources PubMed, Embase, and Web of Science, and studies from 1997 to 2021 were included. Around 1687 papers were screened and 46 studies were included in the final analysis. Result: Three major areas of barriers and facilitators in Type 2 diabetes management were identified: Individual factors: factors which are emerging due to a patient’s personal ability to take care of type 2 diabetes (adherence to diet, physical activity, self-monitoring of blood glucose, medication adherence, psychological factors: this includes emotional factors, beliefs and attitude of patients. Organizational factors: it includes diabetes education factors, economic constraints and health care provider’s issues and social factors: this includes factors associated with family, friends, and others social issues. Conclusion: Identifying barriers to diabetes management is vital to improve the quality of care of diabetes patients, including the improvement of glycemic control, and diabetes self-management. Further research which considers these barriers and facilitators are necessary for developing interventions for individuals with type 2 diabetes.
    Type of Medium: Online Resource
    ISSN: 2349-0659 , 2350-0964
    Language: Unknown
    Publisher: Marwah Infotech
    Publication Date: 2021
    detail.hit.zdb_id: 3030889-6
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  • 2
    Online Resource
    Online Resource
    International Research Journal of Ayurveda & Yoga ; 2023
    In:  International Research Journal of Ayurveda & Yoga Vol. 06, No. 09 ( 2023), p. 26-29
    In: International Research Journal of Ayurveda & Yoga, International Research Journal of Ayurveda & Yoga, Vol. 06, No. 09 ( 2023), p. 26-29
    Type of Medium: Online Resource
    ISSN: 2581-785X
    URL: Issue
    Language: Unknown
    Publisher: International Research Journal of Ayurveda & Yoga
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 2002
    In:  Analytical Biochemistry Vol. 311, No. 1 ( 2002-12), p. 98-99
    In: Analytical Biochemistry, Elsevier BV, Vol. 311, No. 1 ( 2002-12), p. 98-99
    Type of Medium: Online Resource
    ISSN: 0003-2697
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2002
    detail.hit.zdb_id: 1461105-3
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  • 4
    In: Indian Journal of Dermatology, Venereology and Leprology, Scientific Scholar, Vol. 89 ( 2023-01-01), p. 41-46
    Abstract: Although well known in clinical practice, research in lichen planus pigmentosus and related dermal pigmentary diseases is restricted due to lack of consensus on nomenclature and disease definition. Aims and Objectives: Delphi exercise to define and categorise acquired dermal pigmentary diseases. Methods: Core areas were identified including disease definition, etiopathogenesis, risk factors, clinical features, diagnostic methods, treatment modalities and outcome measures. The Delphi exercise was conducted in three rounds. Results: Sixteen researchers representing 12 different universities across India and Australia agreed to be part of this Delphi exercise. At the end of three rounds, a consensus of 〉 80% was reached on usage of the umbrella term ‘acquired dermal macular hyperpigmentation’. It was agreed that there were minimal differences, if any, among the disorders previously defined as ashy dermatosis, erythema dyschromicum perstans, Riehl’s melanosis and pigmented contact dermatitis. It was also agreed that lichen planus pigmentosus, erythema dyschromicum perstans and ashy dermatosis did not differ significantly apart from the sites of involvement, as historically described in the literature. Exposure to hair colours, sunlight and cosmetics was associated with these disorders in a significant proportion of patients. Participants agreed that both histopathology and dermatoscopy could diagnose dermal pigmentation characteristic of acquired dermal macular hyperpigmentation but could not differentiate the individual entities of ashy dermatosis, erythema dyschromicum perstans, Riehl’s melanosis, lichen planus pigmentosus and pigmented contact dermatitis. Limitations: A wider consensus involving representatives from East Asian, European and Latin American countries is required. Conclusion: Acquired dermal macular hyperpigmentation could be an appropriate conglomerate terminology for acquired dermatoses characterised by idiopathic or multifactorial non-inflammatory macular dermal hyperpigmentation.
    Type of Medium: Online Resource
    ISSN: 0973-3922 , 0378-6323
    Language: English
    Publisher: Scientific Scholar
    Publication Date: 2023
    detail.hit.zdb_id: 2129139-1
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  • 5
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-09-21)
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-09-07)
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-09-07)
    Abstract: Urinary tract infections (UTI) are the most common infectious diseases in the world. It is becoming increasingly tough to treat because of emergence of antibiotic resistance. So, there is an exigency to develop novel anti-virulence therapeutics to combat multi-drug resistance pathogenic strains. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) discovery has revolutionized the gene editing technology for targeted approach. The greatest obstacle for CRISPR/Cas9 is cargo delivery systems and both viral and plasmid methods have disadvantages. Here, we report a highly efficient novel CRISPR based gene editing strategy, CRISPR-dots for targeting virulence factor Fimbrial Adhesion ( papG gene), the bacterial adhesion molecule. Carbon quantum dots (CQD) were used as a delivery vehicle for Cas9 and gRNA into CFT073, a UPEC strain. CQDs were covalently conjugated to cas9 and papG -targeted guide RNA (gRNA) forming a nanocomplex CRISPR-dots (Cri-dots) as confirmed by DLS and transmission electron microscopy. Cri-dots- papG significantly targeted papG as demonstrated by decrease in the expression of papG .Further papG deficient UPEC had significantly reduced adherence ability and biofilm forming ability as demonstrated by fluorescence microscopy and scanning electron microscopy. Also, papG deficient UPEC had reduced virulence as shown by significantly increased survival of  Caenorhabditis elegans ( C. elegans ) worms compared to UPEC. Our findings suggest that targeting of papG gene using Cri-dots nanocomplexes significantly reduced the pathogenicity of UPEC. Thus, Cri-dots nanocomplex offer a novel anti-bacterial strategy against multi-drug resistant UPEC.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    American Academy of Pediatrics (AAP) ; 2018
    In:  Pediatrics Vol. 142, No. 1_MeetingAbstract ( 2018-05-01), p. 390-390
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 142, No. 1_MeetingAbstract ( 2018-05-01), p. 390-390
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2018
    detail.hit.zdb_id: 1477004-0
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  • 8
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2016
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 16, No. 11 ( 2016-10-03), p. 1355-1377
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 16, No. 11 ( 2016-10-03), p. 1355-1377
    Type of Medium: Online Resource
    ISSN: 1871-5206
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2016
    SSG: 15,3
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  • 9
    In: Arthritis Research & Therapy, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2020-12)
    Abstract: Ovarian toxicity is a dreaded complication of cyclophosphamide (CYC). With the use of lower cumulative doses of intravenous CYC (modified NIH regimens) and availability of better markers of ovarian toxicity, the incidence of ovarian dysfunction needs reassessment. Lupus disease activity, by itself, is also believed to affect ovarian function negatively. Methods This single-centre prospective cohort study recruited 50 female patients of severe lupus aged 18–40 years. Twenty-five patients each received induction with either monthly intravenous CYC (0.5–0.75 g/m 2 ) for 6–9 months or daily oral mycophenolate mofetil (MMF). Details of menstrual irregularities; serum levels of FSH, LH, estradiol, AMH, and inhibin B; and sonographic assessment of ovarian volume and antral follicular count were done at baseline and 6 months after treatment. Amenorrhoeic patients were re-evaluated at 1 year. Results Mean (SD) age of subjects in the CYC and MMF groups was 31.4 (6.3) and 28.4 (4.4) years, respectively. Mean (SD) SLEDAI at the initiation of therapy was 7.2 (2.5) in the CYC group and 5.8 (3.4) in the MMF group. The mean cumulative dose of CYC used was 4.6 (1.8) g. Three patients in the CYC group (versus none in MMF) had amenorrhoea at 6 months—two of these regained menses within 6 months, while only one (4%) developed sustained amenorrhoea (lasting more than 12 months) at 41 years of age, likely menopause. Serum FSH levels increased ( p  = 0.03), while AMH ( p  = 0.002) and inhibin B ( p   〈  0.001) levels decreased significantly with 6 months of CYC therapy. Ovarian volume also reduced significantly ( p  = 0.005) with 6 months of CYC therapy, while antral follicular count reduced numerically ( p  = 0.32). Levels of AMH, inhibin-B, estradiol, ovarian volume, and antral follicular count after 6 months therapy were significantly lesser in the CYC group compared to the MMF group, despite being similar before the start of therapy. Conclusions Ovarian dysfunction with monthly intravenous CYC (modified NIH regimen) was predominantly subclinical, with a negative effect on ovarian reserve. No premature ovarian failure was noted at 1 year. No ovarian dysfunction occurred in the MMF group, despite having patients with severe background lupus. Use of intravenous CYC for induction may thus not be restricted in young lupus females with incomplete families for fear of gonadotoxicity, especially in life- or organ-threatening situations, where the benefits outweigh this subclinical risk.
    Type of Medium: Online Resource
    ISSN: 1478-6362
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041668-4
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  • 10
    Online Resource
    Online Resource
    GP Innovations Pvt. Ltd. ; 2020
    In:  International Journal of Research in Pharmaceutical Sciences Vol. 11, No. 3 ( 2020-07-09), p. 3459-3464
    In: International Journal of Research in Pharmaceutical Sciences, GP Innovations Pvt. Ltd., Vol. 11, No. 3 ( 2020-07-09), p. 3459-3464
    Abstract: Precision medicine (PM) refers to the modifying of medical or dental treatment according to the individual features of each patient. Imaging has become a central part of PM since the last decade. PM takes into account and aims to exploit the specific profile of the patient’s unique biology and problem. Imaging plays an important role by providing morphologic and functional information, focusing and guiding treatment and assessing response to therapy. Image-guided treatment (IGT), or here specifically image-guided endodontics, is not a strategy that tries to optimize 3-D cleaning, shaping and disinfection, and filling root canal systems. Importantly, IGT is not about simply making a smaller access or smaller shape. It is concept for preserving dentin and restoring the balance. It is about planning access, planning shape using a directed approach, and evaluating the response to treatment. So, in this meta-analysis review, we discuss about the role of image guided therapies like static CT guidance & Dynamic guidance, guided rail based on CBCT (3D printer-based template) used in conventional endodontic therapies and in endodontic surgery. The used of CBCT in the various branches of dentistry such has oral implantology, periodontology has been increased due to its three–dimensional visualization. For the technology to be fully transferred to everyday clinical endodontic practice, there are number of considerations. The novel concepts of guided endodontichas been reported as an effective method to obtain safe and reliable method during variable endodontic procedures.
    Type of Medium: Online Resource
    ISSN: 0975-7538
    URL: Issue
    Language: Unknown
    Publisher: GP Innovations Pvt. Ltd.
    Publication Date: 2020
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