In:
Drug Development Research, Wiley, Vol. 81, No. 3 ( 2020-05), p. 366-373
Abstract:
Seven piperic acid amides along with their lower homologs (12) were synthesized using HATU‐DIPEA coupling reagent. All the synthesized derivatives were evaluated for their antibacterial activities against Staphylococcus aureus , Pseudomonas aeruginosa , and vancomycin‐resistant P. aeruginosa . They were found to be more active on P. aeruginosa than on S. aureus . However, they did not exhibit potent activity on Vancomycin resistant P. aeruginosa . Among the tested compounds, methylenedioxycinnamic acid amide of anthranilic acid (MDCA‐AA, 2a) was found to be most active against S. aureus with MIC of 3.125 μg/ml. The PAS and INH amides of piperic acid were screened against Mycobacterium tuberculosis H37R a strain. They were found to be most active among all the tested compounds but were found to be less active than the standard drug, isoniazid.
Type of Medium:
Online Resource
ISSN:
0272-4391
,
1098-2299
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1500191-X
SSG:
15,3
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