In:
FEBS Letters, Wiley, Vol. 349, No. 1 ( 1994-07-25), p. 39-44
Abstract:
Brunescent (dark brown) cataract is particularly prevalent in the tropics. Enzymatic digestion of the insoluble protein fraction of brunescent cataractous eye lenses from India, followed by high performance liquid chromatographic separation of the pigments and spectroscopic investigations, have led to the identification of one of the pigments as 4‐hydroxyquinoline‐3‐[α‐aminoacetic acid] (compound A). The 4‐hydroxyquinoline moiety is shown to be a photodynamic agent that generates O •− 2 and leads to protein crosslinking. This suggests that the compound A may play a long‐term deleterious role in situ in the lens.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(94)00635-0
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
1460391-3
SSG:
12
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