In:
Current Proteomics, Bentham Science Publishers Ltd., Vol. 16, No. 1 ( 2018-11-23), p. 22-30
Abstract:
Protein homeostasis, or proteostasis, is required for proper cell function and thus must be
under tight maintenance in all circumstances. In crowded cell conditions, protein folding is sometimes unfavorable, and this condition is worsened during stress situations. Cells cope with such stress
through the use of a Protein Quality Control system, which uses molecular chaperones and heat shock proteins as its major players. This system aids with folding, avoiding misfolding and/or reversing aggregation.
A pivotal regulator of the response to heat stress is Heat Shock Factor, which is recruited to the promoters of the chaperone genes, inducting their expression. This mini review aims to cover our
general knowledge on the structure and function of this factor.
Type of Medium:
Online Resource
ISSN:
1570-1646
DOI:
10.2174/1570164615666180713095309
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2018
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