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  • 1
    Online Resource
    Online Resource
    Growth, Tolerance, and Compliance of Infants Fed an Extensively Hydrolyzed Infant Formula with Added 2′-FL Fucosyllactose (2′-FL) Human Milk Oligosaccharide
    MDPI AG ; 2021
    In:  Nutrients Vol. 13, No. 1 ( 2021-01-09), p. 186-
    Details
    In: Nutrients, MDPI AG, Vol. 13, No. 1 ( 2021-01-09), p. 186-
    Abstract: Background: The purpose of this study was to evaluate the growth, tolerance and compliance effects of an extensively hydrolyzed formula with added 2′-FL in an intended use population of infants. Methods: A non-randomized, single-group, multicenter study was conducted. Infants (0–60 days of age) with suspected food protein allergy, persistent feeding intolerance, or presenting conditions where an extensively hydrolyzed formula (eHF) was deemed appropriate were enrolled in a 2-month feeding trial. The primary outcome was maintenance of weight for age z-score during the study. Weight, length, head circumference, formula intake, tolerance measures, clinical symptoms and questionnaires were collected. Forty-eight infants were enrolled and 36 completed the study. Results: Weight for age z-scores of infants showed a statistically significant improvement from study day 1 to study day 60 (0.32 ± 0.11, p = 0.0078). Conclusions: Overall, the results of the study demonstrate that the study formula was well tolerated, safe and supported growth in the intended population.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu13010186
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2518386-2
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  • 2
    Online Resource
    Online Resource
    Nutritional Management of Cow's Milk Allergy in Infants: A Comparison of DRACMA, ESPGHAN, and AAP Guidelines
    Bentham Science Publishers Ltd. ; 2021
    In:  The Open Nutrition Journal Vol. 15, No. 1 ( 2021-04-16), p. 1-9
    Details
    In: The Open Nutrition Journal, Bentham Science Publishers Ltd., Vol. 15, No. 1 ( 2021-04-16), p. 1-9
    Abstract: Cow’s Milk Allergy (CMA) is one of the most common food allergies presented during infancy and childhood. The diagnosis and management of CMA is a complex task. First and foremost, CMA is manifested by a variety of symptoms classified by their type of mediation (either IgE and/or non-IgE responses), organ systems involved, and the onset of the reaction. Second, although several guidelines for the management of CMA have been published worldwide, they differ in their recommendations. To our knowledge, no global consensus exists for the management of the different symptoms associated with CMA. This review provides a table to compare three widely accepted published guidelines to enable the reader to easily navigate and compare the nutritional recommendations to be followed depending on the symptomatology. This review is intended to represent a practical tool to assess the nutritional recommendations for the management of CMA.
    Type of Medium: Online Resource
    ISSN: 1874-2882
    URL: Article
    DOI: 10.2174/1874288202115010001
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
    detail.hit.zdb_id: 2492402-7
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  • 3
    Online Resource
    Online Resource
    Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii
    Cambridge University Press (CUP) ; 2008
    In:  British Journal of Nutrition Vol. 101, No. 4 ( 2008-07-01), p. 541-550
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 101, No. 4 ( 2008-07-01), p. 541-550
    Abstract: Prebiotics are food ingredients that improve health by modulating the colonic microbiota. The bifidogenic effect of the prebiotic inulin is well established; however, it remains unclear which species of Bifidobacterium are stimulated in vivo and whether bacterial groups other than lactic acid bacteria are affected by inulin consumption. Changes in the faecal microbiota composition were examined by real-time PCR in twelve human volunteers after ingestion of inulin (10 g/d) for a 16-d period in comparison with a control period without any supplement intake. The prevalence of most bacterial groups examined did not change after inulin intake, although the low G+C % Gram-positive species Faecalibacterium prausnitzii exhibited a significant increase (10·3 % for control period v. 14·5 % during inulin intake, P  = 0·019). The composition of the genus Bifidobacterium was studied in four of the volunteers by clone library analysis. Between three and five Bifidobacterium spp. were found in each volunteer. Bifidobacterium adolescentis and Bifidobacterium longum were present in all volunteers, and Bifidobacterium pseudocatenulatum , Bifidobacterium animalis , Bifidobacterium bifidum and Bifidobacterium dentium were also detected. Real-time PCR was employed to quantify the four most prevalent Bifidobacterium spp., B. adolescentis , B. longum , B. pseudocatenulatum and B. bifidum , in ten volunteers carrying detectable levels of bifidobacteria. B. adolescentis showed the strongest response to inulin consumption, increasing from 0·89 to 3·9 % of the total microbiota ( P  = 0·001). B. bifidum was increased from 0·22 to 0·63 % ( P   〈  0·001) for the five volunteers for whom this species was present.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114508019880
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2008
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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  • 4
    Online Resource
    Online Resource
    Diversity of approaches to classic galactosemia around the world: a comparison of diagnosis, intervention, and outcomes
    Wiley ; 2012
    In:  Journal of Inherited Metabolic Disease Vol. 35, No. 6 ( 2012-11), p. 1037-1049
    Details
    In: Journal of Inherited Metabolic Disease, Wiley, Vol. 35, No. 6 ( 2012-11), p. 1037-1049
    Abstract: Without intervention, classic galactosemia is a potentially fatal disorder in infancy. With the benefit of early diagnosis and dietary restriction of galactose, the acute sequelae of classic galactosemia can be prevented or reversed. However, despite early and lifelong dietary treatment, many galactosemic patients go on to experience serious long‐term complications including cognitive disability, speech problems, neurological and/or movement disorders and, in girls and women, ovarian dysfunction. Further, there remains uncertainty surrounding what constitutes a ‘best practice’ for treating this disorder. To explore the extent and implications of this uncertainty, we conducted a small but global survey of healthcare providers who follow patients with classic galactosemia, seeking to compare established protocols for diagnosis, intervention, and follow‐up, as well as the outcomes and outcome frequencies seen in the patient populations cared for by these providers. We received 13 survey responses representing five continents and 11 countries. Respondents underscored disparities in approaches to diagnosis, management and follow‐up care. Notably, we saw no clear relationship between differing approaches to care and long‐term outcomes in the populations studied. Negative outcomes occurred in the majority of cases regardless of when treatment was initiated, how tightly galactose intake was restricted, or how closely patients were monitored. We document here what is, to our knowledge, the first global comparison of healthcare approaches to classic galactosemia. These data reinforce the idea that there is currently no one best practice for treating patients with classic galactosemia, and underscore the need for more extensive and statistically powerful comparative studies to reveal potential positive or negative impacts of differing approaches.
    Type of Medium: Online Resource
    ISSN: 0141-8955 , 1573-2665
    URL: Article
    DOI: 10.1007/s10545-012-9477-y
    RVK:
    YC 6270
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2006875-X
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  • 5
    Online Resource
    Online Resource
    Erratum to: Diversity of approaches to classic galactosemia around the world: a comparison of diagnosis, intervention, and outcomes
    Wiley ; 2012
    In:  Journal of Inherited Metabolic Disease Vol. 35, No. 6 ( 2012-11), p. 1157-1157
    Details
    In: Journal of Inherited Metabolic Disease, Wiley, Vol. 35, No. 6 ( 2012-11), p. 1157-1157
    Type of Medium: Online Resource
    ISSN: 0141-8955 , 1573-2665
    URL: Article
    DOI: 10.1007/s10545-012-9516-8
    RVK:
    YC 6270
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2006875-X
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  • 6
    Online Resource
    Online Resource
    Tolerance of Infants Fed a Hydrolyzed Rice Infant Formula with 2′-Fucosyllactose (2′-FL) Human Milk Oligosaccharide (HMO)
    MDPI AG ; 2024
    In:  Nutrients Vol. 16, No. 12 ( 2024-06-13), p. 1863-
    Details
    In: Nutrients, MDPI AG, Vol. 16, No. 12 ( 2024-06-13), p. 1863-
    Abstract: Background: The purpose of this research was to assess the growth, tolerance, and compliance outcomes associated with the consumption of a hydrolyzed rice infant formula (HRF) enriched with 2′-Fucosyllactose (2′-FL) a Human Milk Oligosaccharide (HMO), and nucleotides in an intended population of infants. Methods: This was a non-randomized single-group, multicenter study. The study formula was a hypoallergenic HRF with 2′-FL, Docosahexaenoic acid (DHA), Arachidonic acid (ARA), and nucleotides. Infants 0–90 days of age who were formula fed and experiencing persistent feeding intolerance symptoms, symptoms of suspected food protein (milk and/or soy) allergy, or other conditions where an extensively hydrolyzed infant formula was deemed an appropriate feeding option were recruited by pediatricians from their local populations. The primary outcome was maintenance of weight-for-age z-score. Weight, length, head circumference, formula intake, tolerance measures, clinical symptoms and questionnaires were collected. Thirty-three infants were enrolled, and 27 completed the study, on study product. Results: Weight-for-age z-scores of infants showed a statistically significant improvement from Visit 1 to Visit 4 (p = 0.0331). There was an adequate daily volume intake of 762 ± 28 mL/day, average daily number of stools of 2.1 ± 0.3, and mean rank stool consistency of 2.38 ± 0.18. After 28 days of switching to a HRF, 86.8 ± 5.9% of the symptoms resolved or got better by Visit 4 as reported by parents. Conclusions: HRF with 2′-FL HMO was safe, well tolerated, and supported weight gain in infants with suspected cow’s milk allergy or persistent feeding intolerance.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu16121863
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
    detail.hit.zdb_id: 2518386-2
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