In:
Metal-Based Drugs, Hindawi Limited, Vol. 3, No. 2 ( 1996-01-01), p. 63-66
Abstract:
The [P h 3 PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [P h 3 PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous
cell carcinoma) and SKOV-3 (ovarian carcinoma), both [P h 3 PAu(6-MP)] and [P h 3 PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [P h 3 PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.
Type of Medium:
Online Resource
ISSN:
0793-0291
Language:
English
Publisher:
Hindawi Limited
Publication Date:
1996
detail.hit.zdb_id:
2392146-8
SSG:
15,3
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