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  • 1
    Online Resource
    Online Resource
    Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
    eLife Sciences Publications, Ltd ; 2023
    In:  eLife Vol. 12 ( 2023-02-21)
    Details
    In: eLife, eLife Sciences Publications, Ltd, Vol. 12 ( 2023-02-21)
    Abstract: The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated Ca 2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B cells are poorly understood. Here, we demonstrate changes in the expression of Orai isoforms in response to B cell activation. We show that both Orai3 and Orai1 mediate native CRAC channels in B cells. The combined loss of Orai1 and Orai3, but not Orai3 alone, impairs SOCE, proliferation and survival, nuclear factor of activated T cells (NFAT) activation, mitochondrial respiration, glycolysis, and the metabolic reprogramming of primary B cells in response to antigenic stimulation. Nevertheless, the combined deletion of Orai1 and Orai3 in B cells did not compromise humoral immunity to influenza A virus infection in mice, suggesting that other in vivo co-stimulatory signals can overcome the requirement of BCR-mediated CRAC channel function in B cells. Our results shed important new light on the physiological roles of Orai1 and Orai3 proteins in SOCE and the effector functions of B lymphocytes.
    Type of Medium: Online Resource
    ISSN: 2050-084X
    URL: Article
    DOI: 10.7554/eLife.84708
    Language: English
    Publisher: eLife Sciences Publications, Ltd
    Publication Date: 2023
    detail.hit.zdb_id: 2687154-3
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  • 2
    Online Resource
    Online Resource
    Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling–Deficient Mice
    Rockefeller University Press ; 2003
    In:  The Journal of Experimental Medicine Vol. 198, No. 8 ( 2003-10-20), p. 1157-1169
    Details
    In: The Journal of Experimental Medicine, Rockefeller University Press, Vol. 198, No. 8 ( 2003-10-20), p. 1157-1169
    Abstract: The factors regulating germinal center (GC) B cell fate are poorly understood. Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF; also called BLyS) in promoting primary B cell survival and development. A role for this cytokine in antigen-driven B cell responses has been suggested but current data in this regard are limited. A BAFF receptor expressed by B cells (BAFF-R/BR3) is defective in A/WySnJ mice which exhibit a phenotype similar to BAFF-deficient (BAFF−/−) animals. Here, we show that although GC responses can be efficiently induced in both A/WySnJ and BAFF−/− mice, these responses are not sustained. In BAFF−/− mice, this response is rapidly attenuated and accompanied by perturbed follicular dendritic cell development and immune complex trapping. In contrast, analysis of the A/WySnJ GC response revealed a B cell autonomous proliferative defect associated with reduced or undetectable Ki67 nuclear proliferation antigen expression by GC B cells at all stages of the response. These data demonstrate a multifaceted role for the BAFF pathway in regulating GC progression.
    Type of Medium: Online Resource
    ISSN: 1540-9538 , 0022-1007
    URL: Article
    DOI: 10.1084/jem.20030495
    RVK:
    XA 10000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 2003
    detail.hit.zdb_id: 1477240-1
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  • 3
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    Online Resource
    A Novel Susceptibility Locus On Chromosome 2 in the (New Zealand Black × New Zealand White)F1 Hybrid Mouse Model of Systemic Lupus Erythematosus
    The American Association of Immunologists ; 2002
    In:  The Journal of Immunology Vol. 168, No. 6 ( 2002-03-15), p. 3042-3049
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 168, No. 6 ( 2002-03-15), p. 3042-3049
    Abstract: Systemic lupus erythematosus (SLE) is inherited as a complex polygenic trait. (New Zealand Black (NZB) × New Zealand White (NZW)) F1 hybrid mice develop symptoms that remarkably resemble human SLE, but (NZB × PL/J)F1 hybrids do not develop lupus. Our study was conducted using (NZW × PL/J)F1 × NZB (BWP) mice to determine the effects of the PL/J and the NZW genome on disease. Forty-five percent of BWP female mice had significant proteinuria and 25% died before 12 mo of age compared with (NZB × NZW)F1 mice in which & gt;90% developed severe renal disease and died before 12 mo. The analysis of BWP mice revealed a novel locus (χ2 = 25.0; p & lt; 1 × 10−6; log of likelihood = 6.6 for mortality) designated Wbw1 on chromosome 2, which apparently plays an important role in the development of the disease. We also observed that both H-2 class II (the u haplotype) and TNF-α (TNFz allele) appear to contribute to the disease. A suggestive linkage to proteinuria and death was found for an NZW allele (designated Wbw2) telomeric to the H-2 locus. The NZW allele that overlaps with the previously described locus Sle1c at the telomeric part of chromosome 1 was associated with antinuclear autoantibody production in the present study. Furthermore, the previously identified Sle and Lbw susceptibility loci were associated with an increased incidence of disease. Thus, multiple NZW alleles including the Wbw1 allele discovered in this study contribute to disease induction, in conjunction with the NZB genome, and the PL/J genome appears to be protective.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.168.6.3042
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2002
    detail.hit.zdb_id: 1475085-5
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  • 4
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    Online Resource
    Crucial role of Mer tyrosine kinase in the maintenance of SIGN ‐R1 + marginal zone macrophages
    Wiley ; 2018
    In:  Immunology & Cell Biology Vol. 96, No. 3 ( 2018-03), p. 298-315
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 96, No. 3 ( 2018-03), p. 298-315
    Abstract: Mer Tyrosine Kinase receptor (Mer) is involved in anti‐inflammatory efferocytosis. Here we report elevated spontaneous germinal center (Spt‐ GC ) responses in Mer‐deficient mice (Mer −/− ) that are associated with the loss of SIGN ‐R1 + marginal zone macrophages ( MZM s). The dissipation of MZM s in Mer −/− mice occurs independently of reduced cellularity or delocalization of marginal zone B cells, sinusoidal cells or of CD 169 + metallophillic macrophages. We find that MZM dissipation in Mer −/− mice contributes to apoptotic cell ( AC ) accumulation in Spt‐ GC s and dysregulation of the GC checkpoint, allowing an expansion of DNA ‐reactive B cells in GC s. We further observe that bone marrow derived macrophages from Mer −/− mice produce more TNF α, and are susceptible to cell death upon exposure to AC s compared to WT macrophages. Anti‐ TNF α Ab treatment of Mer −/− mice is, however, unable to reverse MZM loss, but results in reduced Spt‐ GC responses, indicating that TNF α promotes Spt‐ GC responses in Mer −/− mice. Contrary to an anti‐ TNF α Ab treatment, treatment of Mer −/− mice with a synthetic agonist for the transcription factor LXR α rescues a significant number of MZM s in vivo . Our data suggest that Mer‐ LXR α signaling plays an important role in the differentiation and maintenance of MZM s, which in turn regulate Spt‐ GC responses and tolerance.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Issue
    URL: Article
    DOI: 10.1111/imcb.2018.96.issue-3
    DOI: 10.1111/imcb.12003
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2011707-3
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Pain and Functional Outcome with Single dose 25% Dextrose Intra-Articular Injection in Patients with Primary Osteoarthritis of the Knee
    Bangladesh Academy of Sciences ; 2021
    In:  Journal of Dhaka Medical College Vol. 29, No. 2 ( 2021-01-05), p. 138-144
    Details
    In: Journal of Dhaka Medical College, Bangladesh Academy of Sciences, Vol. 29, No. 2 ( 2021-01-05), p. 138-144
    Abstract: Introduction: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. The introduction of 25% Dextrose injection has been viewed as an advance in the management of OA knee. Methods: A prospective, randomized clinical trial was conducted with 84 cases in the Physical Medicine and Rehabilitation (PMR) department of BSMMU. Group A, 42 patients received single dose 25% Dextrose injection intra articular 8ml, exercise and ADL; Group B, 42 patients received exercise and ADL. Outcomes were measured by OA specific translated and validated Bengali instrument- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire and visual analogue scale (VAS 0-10). They were followed up for 6 months. Result: At the initial stage and in week 4, there was no statistical difference between two groups regarding VAS score (as p value was 〉 0.05). But in week 12 and 24, there was highly significant statistical difference regarding VAS score between two groups as the p value was 〈 0.001. Again at the initial stage and week 4, there was no statistical difference between two groups regarding stiffness and physical function score. But in week 12 and 24, there was significant statistical difference regarding stiffness and physical function score between two groups as the p value was less than 0.05. Conclusion: Intra-articular injection of 25% dextrose administered to patients with OA knee has significant effects in pain reduction and functional improvement. J Dhaka Medical College, Vol. 29, No.2, October, 2020, Page 138-144
    Type of Medium: Online Resource
    ISSN: 2219-7494 , 1028-0928
    URL: Article
    DOI: 10.3329/jdmc.v29i2.51188
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2021
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  • 6
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    Online Resource
    Computed Tomographic Evaluation of Renal Mass with Histopathological Correlation
    Bangladesh Academy of Sciences ; 2023
    In:  Bangladesh Medical Journal Vol. 51, No. 1 ( 2023-09-03), p. 41-46
    Details
    In: Bangladesh Medical Journal, Bangladesh Academy of Sciences, Vol. 51, No. 1 ( 2023-09-03), p. 41-46
    Abstract: Renal cell carcinoma (RCC) is the seventh most common cancer and the most common primary renal malignant neoplasm in adults. Computed Tomography (CT) is of a great value in differentiating malignant from benign masses of RCC. This cross-sectional study was conducted among 61 clinically suspected cases of renal mass at Sir Salimullah Medical College and Mitford Hospital (SSMC and Mitford Hospital) in the Department of Radiology and Imaging in collaboration with the Department of Urology and Pathology, from July ’2011 to June’ 2013. However, in 05 cases, histopathological reports were not available and 07 patients refused surgery after enrolling. Finally, histopathology reports were collected from 49 patients and they were considered as study subjects. Aim of the study was to evaluate the accuracy of CT scan findings in compere with the histopathological report for the diagnosis of renal mass and to differentiate its benign and malignant forms. The age range of the patients was 2 to 73 years, where more than two-third (69.38%) were male and rest of them were female. Maximum number of malignant cases observed in the age range of 50-59 years. In comparison, inflammatory and benign conditions dominate in early age group, mostly before 40 years. Among 49 cases, 41 (83.68%) cases were diagnosed as malignant renal mass by CT scan, 01 (2.04) case was missed, which was confirmed by histopathology. Rest 07 (14.28%) patients were diagnosed as benign both in CT scan and histopathology. The sensitivity of CT for malignant renal mass was found 97.62% and specificity was 100%. The positive and negative predictive values of CT were 87.5% and 97.59% respectively. Computed tomography is a valid diagnostic modality for differentiating benign and malignant renal mass. Bangladesh Med J. 2021 Sept; 51(1): 41-46
    Type of Medium: Online Resource
    ISSN: 2219-1607 , 0301-035X
    URL: Article
    DOI: 10.3329/bmj.v51i1.68492
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 2549257-3
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  • 7
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    Online Resource
    Critical Evaluation of Avicennian Cardiac Drugs in the Contemporary Research
    International Journal of Human and Health Sciences IJHHS ; 2020
    In:  International Journal of Human and Health Sciences (IJHHS) Vol. 4, No. 4 ( 2020-05-06), p. 257-
    Details
    In: International Journal of Human and Health Sciences (IJHHS), International Journal of Human and Health Sciences IJHHS, Vol. 4, No. 4 ( 2020-05-06), p. 257-
    Abstract: Lots of clinical and experimental research work had been done to screen the cardiac drugs mentioned by Ibn Sina (980-1037) for their efficacy and safety. Similarly, annotated bibliography of his other works such as major philosophical work (Kitab Shifâ), major medical work (Qanun fil Tibb), minor collective works on logics, poetry, physics, psychology, chemistry-magic, mathematics, music, astronomy, metaphysics, Quranic exegesis, mysticism, ethics, politics, prophecy, etc. and critical editions in almost all languages had been prepared and arranged, which includes publications and references in all major languages. But, to the best of our knowledge, no critical descriptive study has ever been done so far to evaluate the scientific report on all 63 cardiac drugs mentioned in his another famous work, Kitab-al Advia Al Qalbia. There is a need to comment on these drugs on the basis of clinical and experimental study regarding the utility of Ibn Sina’s cardiac drugs. Some of these drugs could be found safe without any reported adverse reactions. Such drugs with safe profile need to be further explored, to select promising and accessible drugs. If toxic effects are reported, then the flagging of such drugs and its present position in clinical utilization should be delineated. The present paper deals and discusses the cardiac drugs described by Ibn Sina in the contemporary research after extensive literature review and meta-analysis. The present work, therefore, provides a useful resource to enable a thorough assessment of the profile of Ibn Sina’s Cardiac drugs that have cardioprotective activity.International Journal of Human and Health Sciences Vol. 04 No. 04 October’20 Page : 257-266
    Type of Medium: Online Resource
    ISSN: 2523-692X
    URL: Article
    DOI: 10.31344/ijhhs.v4i4.210
    Language: Unknown
    Publisher: International Journal of Human and Health Sciences IJHHS
    Publication Date: 2020
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