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  • 1
    Online Resource
    Online Resource
    Uterotrophic response of immature golden hamsters (Mesocricetus auratus) to model estrogen agonists and antagonists
    Elsevier BV ; 2012
    In:  Reproductive Toxicology Vol. 34, No. 2 ( 2012-9), p. 166-167
    Details
    In: Reproductive Toxicology, Elsevier BV, Vol. 34, No. 2 ( 2012-9), p. 166-167
    Type of Medium: Online Resource
    ISSN: 0890-6238
    URL: Article
    DOI: 10.1016/j.reprotox.2012.05.068
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 2010593-9
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  • 2
    Online Resource
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    Evaluation of the hamster Hershberger assay using reference androgens and antiandrogens
    Elsevier BV ; 2012
    In:  Reproductive Toxicology Vol. 34, No. 2 ( 2012-9), p. 168-
    Details
    In: Reproductive Toxicology, Elsevier BV, Vol. 34, No. 2 ( 2012-9), p. 168-
    Type of Medium: Online Resource
    ISSN: 0890-6238
    URL: Article
    DOI: 10.1016/j.reprotox.2012.05.072
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 2010593-9
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  • 3
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    Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins
    MDPI AG ; 2023
    In:  Toxins Vol. 15, No. 9 ( 2023-08-23), p. 515-
    Details
    In: Toxins, MDPI AG, Vol. 15, No. 9 ( 2023-08-23), p. 515-
    Abstract: Fungi such as Aspergillus spp. and Fusarium spp., which are commonly found in the environment, pose a serious global health problem. This study aims to present the results of epidemiological studies, including clinical cases, on the relationship between human exposure to some mycotoxins, especially zearalenone and aflatoxin, and the occurrence of reproductive disorders. In addition, examples of methods to reduce human exposure to mycotoxins are presented. In March 2023, various databases (PubMed, Google Scholar, EMBASE and Web of Science) were systematically searched using Google Chrome to identify studies evaluating the association between exposure to mycotoxins and the occurrence of complications related to impaired fertility or cancer incidence. The analysed data indicate that exposure to the evaluated mycotoxins is widespread and correlates strongly with precocious puberty, reduced fertility and increased cancer incidence in women and men worldwide. There is evidence to suggest that exposure to the Aspergillus mycotoxin aflatoxin (AF) during pregnancy can impair intrauterine foetal growth, promote neonatal jaundice and cause perinatal death and preterm birth. In contrast, exposure to the Fusarium mycotoxin zearalenone (ZEA) leads to precocious sexual development, infertility, the development of malformations and the development of breast cancer. Unfortunately, the development of methods (biological, chemical or physical) to completely eliminate exposure to mycotoxins has limited practical application. The threat to human health from mycotoxins is real and further research is needed to improve our knowledge and specific public health interventions.
    Type of Medium: Online Resource
    ISSN: 2072-6651
    URL: Article
    DOI: 10.3390/toxins15090515
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518395-3
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  • 4
    Online Resource
    Online Resource
    Synthesis and cytotoxicity of new thiazolo[4,5-b]pyridine-2(3H)-one derivatives based on α,β-unsaturated ketones and α-ketoacids
    Springer Science and Business Media LLC ; 2018
    In:  Chemical Papers Vol. 72, No. 3 ( 2018-3), p. 669-681
    Details
    In: Chemical Papers, Springer Science and Business Media LLC, Vol. 72, No. 3 ( 2018-3), p. 669-681
    Type of Medium: Online Resource
    ISSN: 2585-7290 , 1336-9075
    URL: Article
    DOI: 10.1007/s11696-017-0318-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2252770-9
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  • 5
    Online Resource
    Online Resource
    Usefulness of immature golden hamster (Mesocricetus auratus) as a model for uterotrophic assay
    Walter de Gruyter GmbH ; 2015
    In:  Bulletin of the Veterinary Institute in Pulawy Vol. 59, No. 4 ( 2015-12-01), p. 533-540
    Details
    In: Bulletin of the Veterinary Institute in Pulawy, Walter de Gruyter GmbH, Vol. 59, No. 4 ( 2015-12-01), p. 533-540
    Abstract: The present study assessed the sensitivity of immature hamster uterotrophic assay to reference oestrogen agonists/antagonists in order to develop a sensitive model for evaluation of endocrine-active compounds in diets. After performing a baseline for control animals, the sensitivity of immature females (postnatal day 18) to reference compounds was evaluated in a three-day uterotrophic assay. The absolute and adjusted dry uterine weights, fold induction over control for absolute wet uterine weight, and wet uterine weight/body weight ratio (%) were used as endpoints. The significantly active doses for reference oestrogens were as follows: 0.6 μg/kg for 17α-ethinyloestradiol (s.c.); 1 μg/kg/day (s.c.) and 40 μg/kg (p.o.) for diethylstilboestrol; 40 mg/kg (s.c.) and 160 mg/kg (p.o.) for bisphenol A. Co-treatment with tamoxifen at a dose of 1 mg/kg significantly antagonised the uterotrophic effect induced by 1 μg/kg 17α-ethinyloestradiol, and showed the attenuated proliferative effect in histopathological examination. We found immature hamster uterotrophic assay as a sensitive model that could be a good alternative to the rat assay.
    Type of Medium: Online Resource
    ISSN: 2300-3235
    URL: Article
    DOI: 10.1515/bvip-2015-0080
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2015
    detail.hit.zdb_id: 2855010-9
    detail.hit.zdb_id: 2238950-7
    SSG: 22
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  • 6
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    Comparison of albendazole cytotoxicity in terms of metabolite formation in four model systems
    Walter de Gruyter GmbH ; 2017
    In:  Journal of Veterinary Research Vol. 61, No. 3 ( 2017-9-26), p. 313-319
    Details
    In: Journal of Veterinary Research, Walter de Gruyter GmbH, Vol. 61, No. 3 ( 2017-9-26), p. 313-319
    Abstract: Introduction: Albendazole is used to treat endoparasitic diseases in animals and humans. After oral administration, it is quickly oxidised into its pharmacologically active metabolite albendazole sulfoxide and then to sulfone. However, it is not clear which compound is responsible for toxic effects towards mammalian cells. Material and Methods: The model systems comprised cultures of isolated rat hepatocytes, two hepatoma cell lines (FaO, HepG2), and non-hepatic Balb/c 3T3 line. Cells were exposed for 24, 48, and 72 h to eight concentrations of albendazole ranging from 0.05 to 100 μg/mL. At all three time points cytotoxic effects were assessed by MTT assay and metabolites in the culture media were determined by LC-MS/MS analysis. Results: The effective concentrations EC 50-72h showed that Balb/c 3T3 cells were the most sensitive to albendazole (0.2 ±0.1 μg/mL) followed by FaO (1.0 ±0.4 μg/mL), and HepG2 (6.4 ±0.1 μg/mL). In the case of isolated hepatocytes this value could not be attained up to the highest concentration used. Chemical analysis revealed that the concentrations of albendazole in hepatocytes and HepG2 and FaO culture media gradually decreased with incubation time, while the concentrations of its metabolites increased. The metabolism in isolated hepatocytes was dozens of times greater than in HepG2 and FaO cells. Two metabolites (albendazole sulfoxide, albendazole sulfone) were detected in isolated hepatocytes and HepG2 culture medium, one (albendazole sulfoxide) in FaO culture medium and none in Balb/c 3T3. Conclusion: The obtained data indicate that metabolism of albendazole leads to its detoxification. The lower cytotoxic potential of metabolites was confirmed in the independent experiments in this study.
    Type of Medium: Online Resource
    ISSN: 2450-8608
    URL: Article
    DOI: 10.1515/jvetres-2017-0042
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2855010-9
    SSG: 22
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  • 7
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    Differential toxicities of albendazole and its two main metabolites to Balb/c 3T3, HepG2, and FaO lines and rat hepatocytes
    Walter de Gruyter GmbH ; 2016
    In:  Journal of Veterinary Research Vol. 60, No. 4 ( 2016-12-1), p. 495-500
    Details
    In: Journal of Veterinary Research, Walter de Gruyter GmbH, Vol. 60, No. 4 ( 2016-12-1), p. 495-500
    Abstract: Introduction: The cytotoxicity of anthelmintic agent, albendazole (ABZ) and its two major metabolites, sulfoxide (ABZSO) and sulfone (ABZ-SO 2 ), on non-hepatic Balb/c 3T3 line, two hepatoma cell lines (FaO, HepG2), and isolated rat hepatocytes was investigated. Material and Methods: Cell cultures were exposed for 24, 48, and 72 h to eight concentrations of the compounds ranging from 0.05 to 100 μg/mL (ABZ) and from 0.78 to 100 μg/mL (ABZ-SO and ABZ-SO 2 ). Three different assays were applied in which various biochemical endpoints were assessed: lysosomal activity - neutral red uptake (NRU) assay, proliferation - total protein contents (TPC) assay and lactate dehydrogenase (LDH) leakage assay. Results: The most toxic was albendazole whose EC 50 values calculated from the concentration effect curves ranged from 0.2 to 0.5 μg/mL (Balb/c 3T3 ) and from 0.4 to 73.3 μg/mL (HepG2). Rat hepatoma line and isolated rat hepatocytes were less sensitive to the impact of ABZ. Toxic action expressed as EC 50 was recorded after 72 h exposure only in LDH release assay at 0.8 μg/mL and 9.7 μg/mL respectively. The toxicity of metabolites was much lower. The most sensitive to ABZ-SO were fibroblasts and EC 50-72h values were similar in all three assays used, i.e. NRU (14.1 μg/mL), TPC (15.8 μg/mL), and LDH (20.9 μg/mL). In the case of ABZ-SO 2 the mean effective concentrations were the highest, and could be reached only in one LDH assay. These values (μg/mL) were as follows: 65.3 (FaO), 65.4 (HepG2), 75.8 (hepatocytes), and 77.4 (Balb/c 3T3). Conclusion: The differences in in vitro toxicity of albendazole depend on metabolic ability of the cellular models. Primary cultured rat hepatocytes represent a valuable tool to study the impact of biotransformation on the cytotoxicity of drugs.
    Type of Medium: Online Resource
    ISSN: 2450-8608
    URL: Article
    DOI: 10.1515/jvetres-2016-0073
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2855010-9
    SSG: 22
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  • 8
    Online Resource
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    Identification of metabolites of anticancer candidate salinomycin using liquid chromatography coupled with quadrupole time‐of‐flight and hybrid triple quadrupole linear ion trap mass spectrometry
    Wiley ; 2018
    In:  Rapid Communications in Mass Spectrometry Vol. 32, No. 8 ( 2018-04-30), p. 629-634
    Details
    In: Rapid Communications in Mass Spectrometry, Wiley, Vol. 32, No. 8 ( 2018-04-30), p. 629-634
    Abstract: Salinomycin is an ionophore antibiotic with potential anticancer activity. The history of its use in veterinary medicine shows large differences in species susceptibility to its toxicity. At the same time, the results of research to date suggest a correlation between the extent and pathways of ionophore biotransformation and its toxicity. The biotransformation pattern of salinomycin has not been studied so far. Methods Extracts from culture media of human hepatoma cells (HepG2) exposed to salinomycin were analysed with two mass spectrometry techniques. For the first one, micro‐liquid chromatography coupled with a quadrupole time‐of‐flight (Q‐TOF) mass spectrometer was used. In the second approach, high‐performance liquid chromatography was coupled with a hybrid triple quadrupole linear ion trap. Both experiments were operated in positive electrospray ionization mode. To identify unknown salinomycin metabolites, information‐dependent acquisition was applied. Results Metabolites identified with tandem mass spectrometry included hydroxylated, demethylated and hydroxylated–demethylated derivatives, in total 14 compounds. Using high resolution, only eight isomers of hydroxysalinomycin were detected. The efficiency of biotransformation was low, and so was the abundance of the signals; only for two metabolites did the signal exceed 1% of the salinomycin signal. The analysis of fragmentation patterns narrowed the structure combinations but the actual modification site could not be specified. Conclusions Tandem mass spectrometry was more sensitive in the identification of salinomycin metabolites in comparison to the Q‐TOF approach. Because of low efficiency of biotransformation of the applied model, the obtained fragmentation data are not sufficient to fully characterize the detected compounds. A study with more metabolically active primary hepatocytes is needed.
    Type of Medium: Online Resource
    ISSN: 0951-4198 , 1097-0231
    URL: Issue
    URL: Article
    DOI: 10.1002/rcm.v32.8
    DOI: 10.1002/rcm.8082
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2002158-6
    detail.hit.zdb_id: 58731-X
    SSG: 11
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  • 9
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    Evaluation of estrogenic activity in animal diets using in vitro assay
    Elsevier BV ; 2014
    In:  Toxicology in Vitro Vol. 28, No. 1 ( 2014-02), p. 70-75
    Details
    In: Toxicology in Vitro, Elsevier BV, Vol. 28, No. 1 ( 2014-02), p. 70-75
    Type of Medium: Online Resource
    ISSN: 0887-2333
    URL: Article
    DOI: 10.1016/j.tiv.2013.10.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1501079-X
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  • 10
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    Cytotoxicity of anticancer candidate salinomycin and identification of its metabolites in rat cell cultures
    Elsevier BV ; 2018
    In:  Toxicology in Vitro Vol. 52 ( 2018-10), p. 314-320
    Details
    In: Toxicology in Vitro, Elsevier BV, Vol. 52 ( 2018-10), p. 314-320
    Type of Medium: Online Resource
    ISSN: 0887-2333
    URL: Article
    DOI: 10.1016/j.tiv.2018.07.006
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 1501079-X
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