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  • 1
    Online Resource
    Online Resource
    Evaluating a novel 24-hour rest/activity rhythm marker of preclinical β-amyloid deposition
    Oxford University Press (OUP) ; 2024
    In:  SLEEP Vol. 47, No. 5 ( 2024-05-10)
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 47, No. 5 ( 2024-05-10)
    Abstract: To compare sleep and 24-hour rest/activity rhythms (RARs) between cognitively normal older adults who are β-amyloid-positive (Aβ+) or Aβ− and replicate a novel time-of-day-specific difference between these groups identified in a previous exploratory study. Methods We studied 82 cognitively normal participants from the Baltimore Longitudinal Study of Aging (aged 75.7 ± 8.5 years, 55% female, 76% white) with wrist actigraphy data and Aβ+ versus Aβ− status measured by [11C] Pittsburgh compound B positron emission tomography. RARs were calculated using epoch-level activity count data from actigraphy. We used novel, data-driven function-on-scalar regression analyses and standard RAR metrics to cross-sectionally compare RARs between 25 Aβ+ and 57 Aβ− participants. Results Compared to Aβ− participants, Aβ+ participants had higher mean activity from 1:00 p.m. to 3:30 p.m. when using less conservative pointwise confidence intervals (CIs) and from 1:30 p.m. to 2:30 p.m. using more conservative, simultaneous CIs. Furthermore, Aβ+ participants had higher day-to-day variability in activity from 9:00 a.m. to 11:30 a.m. and lower variability from 1:30 p.m. to 4:00 p.m. and 7:30 p.m. to 10:30 p.m. according to pointwise CIs, and lower variability from 8:30 p.m. to 10:00 p.m. using simultaneous CIs. There were no Aβ-related differences in standard sleep or RAR metrics. Conclusions Findings suggest Aβ+ older adults have higher, more stable day-to-day afternoon/evening activity than Aβ− older adults, potentially reflecting circadian dysfunction. Studies are needed to replicate our findings and determine whether these or other time-of-day-specific RAR features have utility as markers of preclinical Aβ deposition and if they predict clinical dementia and agitation in the afternoon/evening (i.e. “sundowning”).
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsae037
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2056761-3
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  • 2
    Online Resource
    Online Resource
    Early Childhood Behavioral and Academic Antecedents of Lifetime Opioid Misuse among Urban Youth
    Informa UK Limited ; 2022
    In:  Journal of Clinical Child & Adolescent Psychology Vol. 51, No. 6 ( 2022-11-02), p. 864-876
    Details
    In: Journal of Clinical Child & Adolescent Psychology, Informa UK Limited, Vol. 51, No. 6 ( 2022-11-02), p. 864-876
    Type of Medium: Online Resource
    ISSN: 1537-4416 , 1537-4424
    URL: Article
    DOI: 10.1080/15374416.2021.1875324
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2073313-6
    SSG: 5,2
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  • 3
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    Association of common infections with cognitive performance in the Baltimore Epidemiologic Catchment Area study follow‐up
    Wiley ; 2023
    In:  Alzheimer's & Dementia
    Details
    In: Alzheimer's & Dementia, Wiley
    Abstract: Growing evidence suggests that some common infections are causally associated with cognitive impairment; however, less is known about the burden of multiple infections. Methods We investigated the cross‐sectional association of positive antibody tests for herpes simplex virus, cytomegalovirus (CMV), Epstein‐Barr virus (EBV), varicella zoster virus (VZV), and Toxoplasma gondii (TOX) with Mini‐Mental State Examination (MMSE) and delayed verbal recall performance in 575 adults aged 41–97 from the Baltimore Epidemiologic Catchment Area Study. Results In multivariable‐adjusted zero‐inflated Poisson (ZIP) regression models, positive antibody tests for CMV ( p  = .011) and herpes simplex virus ( p  = .018) were individually associated with poorer MMSE performance ( p  = .011). A greater number of positive antibody tests among the five tested was associated with worse MMSE performance ( p  = .001). Discussion CMV, herpes simplex virus, and the global burden of multiple common infections were independently associated with poorer cognitive performance. Additional research that investigates whether the global burden of infection predicts cognitive decline and Alzheimer's disease biomarker changes is needed to confirm these findings.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1002/alz.13070
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2201940-6
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  • 4
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    Online Resource
    Social Influences on Drinking Trajectories From Adolescence to Young Adulthood in an Urban Minority Sample
    Alcohol Research Documentation, Inc. ; 2019
    In:  Journal of Studies on Alcohol and Drugs Vol. 80, No. 2 ( 2019-03), p. 186-195
    Details
    In: Journal of Studies on Alcohol and Drugs, Alcohol Research Documentation, Inc., Vol. 80, No. 2 ( 2019-03), p. 186-195
    Type of Medium: Online Resource
    ISSN: 1937-1888 , 1938-4114
    URL: Article
    DOI: 10.15288/jsad.2019.80.186
    Language: English
    Publisher: Alcohol Research Documentation, Inc.
    Publication Date: 2019
    SSG: 15,3
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  • 5
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    The role of negative emotional reactivity and neighborhood factors in predicting marijuana use during early adolescence
    Wiley ; 2020
    In:  Journal of Adolescence Vol. 85, No. 1 ( 2020-12), p. 32-40
    Details
    In: Journal of Adolescence, Wiley, Vol. 85, No. 1 ( 2020-12), p. 32-40
    Abstract: Negative emotional reactivity and the neighborhood environment have been individually associated with marijuana use outcomes; however, less is known about whether neighborhood factors differentiate the association between negative emotional reactivity and marijuana use. The present study examined whether neighborhood risk (i.e., neighborhood problems) and protective factors (i.e., neighborhood social cohesion) moderated the relation between negative emotional reactivity and marijuana use during early adolescence. Methods. Participants were 775 adolescents (M = 10.95 ± 0.88 years; 69% male; 76% Caucasian), who reported on their past month frequency of marijuana use at Time 1 (when adolescents were 10‐12 years old) and Time 2 (when adolescents were 12‐14 years old). Mothers reported on neighborhood problems and neighborhood social cohesion at Time 1. Youth reported on their negative emotional reactivity at Time 2. Results Negative binomial regression analyses indicated that neighborhood problems moderated the relationship between negative emotional reactivity and marijuana use. In particular, in the context of low neighborhood problems, individuals with lower negative emotional reactivity were at attenuated risk for marijuana use compared to individuals higher in negative emotional reactivity. In the context of high neighborhood problems, individuals were at heightened risk for marijuana consumption regardless of their negative emotional reactivity levels. Conclusions Findings suggest that individual‐level factors alone do not sufficiently account for early marijuana use and that neighborhood problems play a role in risk for or abstention from using marijuana during early adolescence. Implications for prevention and intervention for marijuana use during adolescence are discussed.
    Type of Medium: Online Resource
    ISSN: 0140-1971 , 1095-9254
    URL: Article
    DOI: 10.1016/j.adolescence.2020.09.002
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1469149-8
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  • 6
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    Online Resource
    Associations Between Objectively Measured Sleep and Cognition: Main Effects and Interactions With Race in Adults Aged ≥50 Years
    Oxford University Press (OUP) ; 2023
    In:  The Journals of Gerontology: Series A Vol. 78, No. 3 ( 2023-03-01), p. 454-462
    Details
    In: The Journals of Gerontology: Series A, Oxford University Press (OUP), Vol. 78, No. 3 ( 2023-03-01), p. 454-462
    Abstract: This study examined associations of actigraphy-estimated sleep parameters with concurrent and future cognitive performance in adults aged ≥ 50 years and explored interactions with race. Methods Participants were 435 cognitively normal adults in the Baltimore Longitudinal Study of Aging who completed wrist actigraphy at baseline (mean = 6.6 nights) and underwent longitudinal testing of memory, attention, executive function, language, and visuospatial ability. On average, participants with follow-up data were followed for 3.1 years. Primary predictors were baseline mean total sleep time, sleep onset latency, sleep efficiency (SE), and wake after sleep onset (WASO). Fully adjusted linear mixed-effects models included demographics, baseline health-related characteristics, smoking status, sleep medication use, APOE e4 carrier status, and interactions of each covariate with time. Results In adjusted models, higher SE (per 10%; B = 0.11, p = .012) and lower WASO (per 30 minutes; B = −0.12, p = .007) were associated with better memory cross-sectionally. In contrast, higher SE was associated with greater visuospatial ability decline longitudinally (B = −0.02, p = .004). Greater WASO was associated with poorer visuospatial ability cross-sectionally (B = −0.09, p = .019) but slower declines in visuospatial abilities longitudinally (B = 0.02, p = .002). Several sleep-cognition cross-sectional and longitudinal associations were stronger in, or limited to, Black participants (compared to White participants). Conclusions This study suggests cross-sectional sleep-cognition associations differ across distinct objective sleep parameters and cognitive domains. This study also provides preliminary evidence for racial differences across some sleep-cognition relationships. Unexpected directions of associations between baseline sleep and cognitive performance over time may be attributable to the significant proportion of participants without follow-up data and require further investigation.
    Type of Medium: Online Resource
    ISSN: 1079-5006 , 1758-535X
    URL: Article
    DOI: 10.1093/gerona/glac180
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2043927-1
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Comparison of sleep parameters from wrist-worn ActiGraph and Actiwatch devices
    Oxford University Press (OUP) ; 2023
    In:  SLEEP ( 2023-05-31)
    Details
    In: SLEEP, Oxford University Press (OUP), ( 2023-05-31)
    Abstract: Sleep and physical activity, two important health behaviors, are often studied independently using different accelerometer types and body locations. Understanding whether accelerometers designed for monitoring each behavior can provide similar sleep parameter estimates may help determine whether one device can be used to measure both behaviors. Three hundred and thirty one adults (70.7 ± 13.7 years) from the Baltimore Longitudinal Study of Aging wore the ActiGraph GT9X Link and the Actiwatch 2 simultaneously on the non-dominant wrist for 7.0 ± 1.6 nights. Total sleep time (TST), wake after sleep onset (WASO), sleep efficiency, number of wake bouts, mean wake bout length, and sleep fragmentation index (SFI) were extracted from ActiGraph using the Cole–Kripke algorithm and from Actiwatch using the software default algorithm. These parameters were compared using paired t-tests, Bland–Altman plots, and Deming regression models. Stratified analyses were performed by age, sex, and body mass index (BMI). Compared to the Actiwatch, the ActiGraph estimated comparable TST and sleep efficiency, but fewer wake bouts, longer WASO, longer wake bout length, and higher SFI (all p  & lt; .001). Both devices estimated similar 1-min and 1% differences between participants for TST and SFI (β = 0.99, 95% CI: 0.95, 1.03, and 0.91, 1.13, respectively), but not for other parameters. These differences varied by age, sex, and/or BMI. The ActiGraph and the Actiwatch provide comparable absolute and relative estimates of TST, but not other parameters. The discrepancies could result from device differences in movement collection and/or sleep scoring algorithms. Further comparison and calibration is required before these devices can be used interchangeably.
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsad155
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2056761-3
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  • 8
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    Online Resource
    Individual and Neighborhood Factors Associated With Sexual Behavior Classes in an Urban Longitudinal Sample
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Sexually Transmitted Diseases Vol. 46, No. 2 ( 2019-2), p. 98-104
    Details
    In: Sexually Transmitted Diseases, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 2 ( 2019-2), p. 98-104
    Abstract: This study aimed to increase understanding of the clustering of sexual behaviors in an urban sample of emerging adults, and the individual and neighborhood factors associated with sexual behavior patterns to provide insight into reducing the disproportionate burden of poor sexual outcomes among urban African Americans. Methods We draw on 2 cohorts of urban, predominantly African American youth first assessed at age 6 years and follow-up to emerging adulthood (mean age, 20 years; n = 1618). Latent class analyses by gender identified co-occurrence of sexual behavior. Results We found 3 classes for both males and females: high-risk (13% of males, 15% of females), low-risk (54% of males, 56% of females) and no-risk (33% of males, 29% of females). Membership in the high-risk class was associated with school dropout, a substance use disorder diagnosis, having a criminal arrest, pregnancy, and sexually transmitted diseases for both males and females. High-risk females also had higher rates of depression. Low-risk males and females also had elevated risk of pregnancy and parenthood. Neighborhood factors distinguished the high- and no-risk classes for males and females, including the neighborhood environment scale, which assessed poverty, safety, drug activity, and crime/violence in the neighborhood. Neighborhood religiosity was inversely associated with membership in the high-risk class compared with the no-risk class for females only. Neighborhood racism distinguished those in the high-risk class compared with the no-risk class for males. Conclusions Future work should take into account the clustering of sexual risk behaviors. Specific neighborhood factors could be addressed to reduce sexual health disparities.
    Type of Medium: Online Resource
    ISSN: 1537-4521 , 0148-5717
    URL: Article
    DOI: 10.1097/OLQ.0000000000000920
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2055170-8
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  • 9
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    Online Resource
    Alcohol Trajectories and Subsequent Risk for Opioid Misuse in a Cohort of Urban Adolescents
    SAGE Publications ; 2021
    In:  Substance Abuse Vol. 42, No. 4 ( 2021-10), p. 873-879
    Details
    In: Substance Abuse, SAGE Publications, Vol. 42, No. 4 ( 2021-10), p. 873-879
    Abstract: The opioid epidemic is a public health emergency in the US. Alcohol is the most widely used addictive substance among all age groups; however, the contribution of different alcohol use trajectories throughout adolescence and young adulthood to the development of opioid misuse in young adulthood among urban minority youth has not been investigated. Methods Data are from a study of 580 youth (85% African American, 67% low SES) residing in Baltimore City followed from ages 6–26. Alcohol trajectories were identified between ages 14 and 26 using group-based trajectory modeling. Opioid misuse was defined as using opioid painkillers without a prescription or using heroin between ages 19 and 26. Opioid misuse outcomes were also investigated separately. Logistic regression examined associations of alcohol trajectories with opioid misuse in young adulthood adjusting for socio-demographics, early use of tobacco and cannabis, neighborhood, and peer factors. Results Six alcohol use trajectories were identified: Young adult increasing (21.4%), adult increasing (19.1%), abstaining (19.1%), experimenting (15.3%), adolescent increasing (14.8%), and adolescent limited (10.2%). In models fully adjusted for covariates, relative to the abstaining trajectory, the adolescent increasing trajectory was associated with an elevated risk of opioid misuse (aOR = 3.3, 95%CI = 1.4, 7.8) and prescription opioid misuse (aOR = 3.9, 95%CI = 1.4, 10.8) in young adulthood. Conclusions Escalating alcohol use in adolescence and young adulthood is associated with an elevated risk of opioid misuse in young adulthood in a cohort of predominantly African American and socio-economically disadvantaged young people. Tailored interventions should target high levels of alcohol use during these developmental periods to reduce risk for opioid misuse among disadvantaged youth.
    Type of Medium: Online Resource
    ISSN: 0889-7077 , 1547-0164
    URL: Article
    DOI: 10.1080/08897077.2021.1890675
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2018838-9
    SSG: 5,2
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  • 10
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    Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use
    Oxford University Press (OUP) ; 2022
    In:  Cerebral Cortex Vol. 32, No. 4 ( 2022-02-08), p. 796-807
    Details
    In: Cerebral Cortex, Oxford University Press (OUP), Vol. 32, No. 4 ( 2022-02-08), p. 796-807
    Abstract: Genome-wide association studies (GWAS) have identified genetic variants associated with brain morphology and substance use behaviors (SUB). However, the genetic overlap between brain structure and SUB has not been well characterized. We leveraged GWAS summary data of 71 brain imaging measures and alcohol, tobacco, and cannabis use to investigate their genetic overlap using linkage disequilibrium score regression. We used genomic structural equation modeling to model a “common SUB genetic factor” and investigated its genetic overlap with brain structure. Furthermore, we estimated SUB polygenic risk scores (PRS) and examined whether they predicted brain imaging traits using the Adolescent Behavior and Cognitive Development (ABCD) study. We identified 8 significant negative genetic correlations, including between (1) alcoholic drinks per week and average cortical thickness, and (2) intracranial volume with age of smoking initiation. We observed 5 positive genetic correlations, including those between (1) insula surface area and lifetime cannabis use, and (2) the common SUB genetic factor and pericalcarine surface area. SUB PRS were associated with brain structure variation in ABCD. Our findings highlight a shared genetic etiology between cortical brain morphology and SUB and suggest that genetic variants associated with SUB may be causally related to brain structure differences.
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    URL: Article
    DOI: 10.1093/cercor/bhab243
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1483485-6
    SSG: 12
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