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  • 1
    Online Resource
    Online Resource
    Proeating disorder websites and subjective well‐being: A four‐country study on young people
    Wiley ; 2017
    In:  International Journal of Eating Disorders Vol. 50, No. 1 ( 2017-01), p. 50-57
    Details
    In: International Journal of Eating Disorders, Wiley, Vol. 50, No. 1 ( 2017-01), p. 50-57
    Abstract: Proeating disorder (pro‐ED) communities online encourage harmful weight‐loss and weight‐control practices. This study examined the association between exposure to pro‐ED content online and subjective well‐being (SWB) among adolescents and young adults in four countries. Method Cross‐national data were collected in the US, Germany, the UK and Finland from Internet users aged 15–30 years ( N  = 3,557; 50.15% male). The questionnaire assessed SWB, exposure to harm‐advocating websites, online activity, prior victimization, and social belonging. Ordinary least squares (OLS) regression models assessed the relationship between SWB and pro‐ED exposure and adjusted for a number of confounding factors. Results Of the participants, 17% had been exposed to pro‐ED content (US 20%, Germany 7%, UK 21%, Finland 22%). Exposure to pro‐ED content online was negatively associated with SWB in the US, Germany, and Finland, also after adjusting for the confounding factors. Offline social belonging moderated the association between pro‐ED and SWB. Discussion Participants who visited pro‐ED websites reported lower SWB than others did. The potentially harmful impact of visiting these sites was buffered by the strong offline social belonging. Given the observed similarities across the countries, it is important for families, health professionals, and educators to stay abreast of online communities that have possible contra recovery influences and to be able to discuss such Internet contents in a way that increases treatment motivation. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2017; 50:50–57)
    Type of Medium: Online Resource
    ISSN: 0276-3478 , 1098-108X
    URL: Issue
    URL: Article
    DOI: 10.1002/eat.v50.1
    DOI: 10.1002/eat.22589
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1492880-2
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  • 2
    Online Resource
    Online Resource
    Fungal enzyme production and biodegradation of polychlorinated dibenzo-p-dioxins and dibenzofurans in contaminated sawmill soil
    Elsevier BV ; 2014
    In:  Chemosphere Vol. 110 ( 2014-09), p. 85-90
    Details
    In: Chemosphere, Elsevier BV, Vol. 110 ( 2014-09), p. 85-90
    Type of Medium: Online Resource
    ISSN: 0045-6535
    URL: Article
    DOI: 10.1016/j.chemosphere.2014.03.079
    RVK:
    AR 10100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1496851-4
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  • 3
    Online Resource
    Online Resource
    Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart
    American Physiological Society ; 2021
    In:  American Journal of Physiology-Endocrinology and Metabolism Vol. 321, No. 6 ( 2021-12-01), p. E753-E765
    Details
    In: American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 321, No. 6 ( 2021-12-01), p. E753-E765
    Abstract: Cardiac muscle uses multiple sources of energy including glucose and fatty acid (FA). The heart cannot synthesize FA and relies on obtaining it from other sources, with lipoprotein lipase (LPL) breakdown of lipoproteins suggested to be a key source of FA for cardiac use. Recent work has indicated that cardiac vascular endothelial growth factor B (VEGFB) overexpression expands the coronary vasculature and facilitates metabolic reprogramming that favors glucose utilization. We wanted to explore whether this influence of VEGFB on cardiac metabolism involves regulation of LPL activity with consequent effects on lipotoxicity and insulin signaling. The transcriptomes of rats with and without cardiomyocyte-specific overexpression of human VEGFB were compared by using RNA sequencing. Isolated perfused hearts or cardiomyocytes incubated with heparin were used to enable measurement of LPL activity. Untargeted metabolomic analysis was performed for quantification of cardiac lipid metabolites. Cardiac insulin sensitivity was evaluated using fast-acting insulin. Isolated heart and cardiomyocytes were used to determine transgene-encoded VEGFB isoform secretion patterns and mitochondrial oxidative capacity using high-resolution respirometry and extracellular flux analysis. In vitro, transgenic cardiomyocytes incubated overnight and thus exposed to abundantly secreted VEGFB isoforms, in the absence of any in vivo confounding regulators of cardiac metabolism, demonstrated higher basal oxygen consumption. In the whole heart, VEGFB overexpression induced an angiogenic response that was accompanied by limited cardiac LPL activity through multiple mechanisms. This was associated with a lowered accumulation of lipid intermediates, diacylglycerols and lysophosphatidylcholine, that are known to influence insulin action. In response to exogenous insulin, transgenic hearts demonstrated increased insulin sensitivity. In conclusion, the interrogation of VEGFB function on cardiac metabolism uncovered an intriguing and previously unappreciated effect to lower LPL activity and prevent lipid metabolite accumulation to improve insulin action. VEGFB could be a potential cardioprotective therapy to treat metabolic disorders, for example, diabetes. NEW & NOTEWORTHY In hearts overexpressing vascular endothelial growth factor B (VEGFB), besides its known angiogenic response, multiple regulatory mechanisms lowered coronary LPL. This was accompanied by limited cardiac lipid metabolite accumulation with an augmentation of cardiac insulin action. Our data for the first time links VEGFB to coronary LPL in regulation of cardiac metabolism. VEGFB may be cardioprotective in metabolic disorders like diabetes.
    Type of Medium: Online Resource
    ISSN: 0193-1849 , 1522-1555
    URL: Article
    DOI: 10.1152/ajpendo.00219.2021
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2021
    detail.hit.zdb_id: 1477331-4
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Contribution of parental health to the subsequent social assistance entry of the family with children: a nationwide register-linked birth cohort study in Finland
    BMJ ; 2023
    In:  Journal of Epidemiology and Community Health Vol. 77, No. 4 ( 2023-04), p. 224-229
    Details
    In: Journal of Epidemiology and Community Health, BMJ, Vol. 77, No. 4 ( 2023-04), p. 224-229
    Abstract: Our aim in this paper was to estimate the contribution of different parental specialised health care diagnoses to the subsequent risk of entry into the social assistance system for families with children in the period 1998–2013. Methods We used longitudinal population-level register data consisting of all children born in 1997 in Finland and their registered parents (54 960 one and two-parent families with 801 336 observations in the period 1998–2013). Diagnoses assigned in public specialised healthcare and social assistance records were derived from nationwide administrative registers. Measures of parental socioeconomic status and previous diagnoses and the birth weight of the child were adjusted for in regression models which estimated the association between parental diagnoses and entry into the social assistance system in the following year. Results Families with a parent somatic diagnosis had a risk ratio of 1.4 for social assistance entry in the subsequent year of the diagnosis though substantial variation by diagnosis category was detected. Parent psychiatric diagnoses were linked to a higher, 3.01-fold risk of social assistance entry. Covariate adjustment reduced these risk ratios to 1.2 and 2.1, respectively. Some 2.9% of all social assistance entries may be attributed to parental psychiatric diagnoses while somatic health records account for another 7.2%, making their total contribution over 1/10th of all cases. Conclusion Parental specialised healthcare records were associated with a higher risk of social assistance need. Thus more interventions to support financial management are required for parents with psychiatric diagnoses.
    Type of Medium: Online Resource
    ISSN: 0143-005X , 1470-2738
    URL: Article
    DOI: 10.1136/jech-2023-220283
    Language: English
    Publisher: BMJ
    Publication Date: 2023
    detail.hit.zdb_id: 2015405-7
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  • 5
    Online Resource
    Online Resource
    The Role of Political Activity in the Formation of Online Identity Bubbles
    Wiley ; 2019
    In:  Policy & Internet Vol. 11, No. 4 ( 2019-12), p. 396-417
    Details
    In: Policy & Internet, Wiley, Vol. 11, No. 4 ( 2019-12), p. 396-417
    Abstract: El aumento en el uso de las redes sociales ha transformado la participación política al crear camarillas sociales y cámaras de eco, que involucran la interacción entre personas de ideas afines. Este artículo examina la relación entre la actividad política en línea y la participación personal en las burbujas de identidad en línea. Este estudio es el primero en examinar este fenómeno utilizando datos representativos a nivel nacional; sus datos se derivaron de encuestas dirigidas a finlandeses de 18–74 años (n = 3,724). Las medidas incluyeron la actividad política en línea, la Escala de refuerzo de burbujas de identidad y los factores demográficos y de comportamiento. Los resultados muestran que la actividad política en línea se asoció positivamente con las burbujas de identidad en línea. Este efecto fue fuerte incluso después de controlar los factores demográficos y de comportamiento. Además de la actividad política en línea, la actividad general en línea, el tamaño de la red en línea y las variables básicas de antecedentes sociodemográficos explicaron la variación de la participación en las burbujas de identidad en línea. Sin embargo, ni la preferencia política, ni el interés político tuvieron un efecto sistemático sobre la participación en estas burbujas. Los hallazgos confirman el supuesto teórico de que las burbujas en línea se pueden capturar utilizando medidas de encuesta subjetivas. La actividad política parece ser un factor clave asociado con la fortaleza de la experiencia de la burbuja en línea. Este hallazgo tiene importancia en la sociedad de la información contemporánea, en la que varias discusiones mundanas y disputas culturales se tiñen políticamente.
    Type of Medium: Online Resource
    ISSN: 1944-2866 , 1944-2866
    URL: Issue
    URL: Article
    DOI: 10.1002/poi3.v11.4
    DOI: 10.1002/poi3.211
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2527143-X
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  • 6
    Online Resource
    Online Resource
    Pro-Anorexia and Anti-Pro-Anorexia Videos on YouTube: Sentiment Analysis of User Responses
    JMIR Publications Inc. ; 2015
    In:  Journal of Medical Internet Research Vol. 17, No. 11 ( 2015-11-12), p. e256-
    Details
    In: Journal of Medical Internet Research, JMIR Publications Inc., Vol. 17, No. 11 ( 2015-11-12), p. e256-
    Type of Medium: Online Resource
    ISSN: 1438-8871
    URL: Article
    DOI: 10.2196/jmir.5007
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2015
    detail.hit.zdb_id: 2028830-X
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  • 7
    Online Resource
    Online Resource
    Cybercrime Victimization and Subjective Well-Being: An Examination of the Buffering Effect Hypothesis Among Adolescents and Young Adults
    Mary Ann Liebert Inc ; 2018
    In:  Cyberpsychology, Behavior, and Social Networking Vol. 21, No. 2 ( 2018-02), p. 129-137
    Details
    In: Cyberpsychology, Behavior, and Social Networking, Mary Ann Liebert Inc, Vol. 21, No. 2 ( 2018-02), p. 129-137
    Type of Medium: Online Resource
    ISSN: 2152-2715 , 2152-2723
    URL: Article
    DOI: 10.1089/cyber.2016.0728
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2018
    detail.hit.zdb_id: 2545735-4
    SSG: 5,2
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  • 8
    Online Resource
    Online Resource
    Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle
    Wiley ; 2018
    In:  Journal of Cachexia, Sarcopenia and Muscle Vol. 9, No. 2 ( 2018-04), p. 417-432
    Details
    In: Journal of Cachexia, Sarcopenia and Muscle, Wiley, Vol. 9, No. 2 ( 2018-04), p. 417-432
    Abstract: Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of life. Doxorubicin (DOX) is an effective cytostatic agent, which unfortunately has toxic effects on many healthy tissues. Blocking of activin receptor type IIB (ACVR2B) ligands is an often used strategy to prevent skeletal muscle loss, but its effects on the heart are relatively unknown. Methods The effects of DOX treatment with or without pre‐treatment with soluble ACVR2B‐Fc (sACVR2B‐Fc) were investigated. The mice were randomly assigned into one of the three groups: (1) vehicle (PBS)‐treated controls, (2) DOX‐treated mice (DOX), and (3) DOX‐treated mice administered with sACVR2B‐Fc during the experiment (DOX + sACVR2B‐Fc). DOX was administered with a cumulative dose of 24 mg/kg during 2 weeks to investigate cachexia outcome in the heart and skeletal muscle. To understand similarities and differences between skeletal and cardiac muscles in their responses to chemotherapy, the tissues were collected 20 h after a single DOX (15 mg/kg) injection and analysed with genome‐wide transcriptomics and mRNA and protein analyses. The combination group was pre‐treated with sACVR2B‐Fc 48 h before DOX administration. Major findings were also studied in mice receiving only sACVR2B‐Fc. Results The DOX treatment induced similar (~10%) wasting in skeletal muscle and the heart. However, transcriptional changes in response to DOX were much greater in skeletal muscle. Pathway analysis and unbiased transcription factor analysis showed that p53‐p21‐REDD1 is the main common pathway activated by DOX in both skeletal and cardiac muscles. These changes were attenuated by blocking ACVR2B ligands especially in skeletal muscle. Tceal7 (3‐fold to 5‐fold increase), transferrin receptor (1.5‐fold increase), and Ccl21 (0.6‐fold to 0.9‐fold decrease) were identified as novel genes responsive to blocking ACVR2B ligands. Overall, at the transcriptome level, ACVR2B ligand blocking had only minor influence in the heart while it had marked effects in skeletal muscle. The same was also true for the effects on tissue wasting. This may be explained in part by about 18‐fold higher gene expression of myostatin in skeletal muscle compared with the heart. Conclusions Cardiac and skeletal muscles display similar atrophy after DOX treatment, but the mechanisms for this may differ between the tissues. The present results suggest that p53‐p21‐REDD1 signalling is the main common DOX‐activated pathway in these tissues and that blocking activin receptor ligands attenuates this response, especially in skeletal muscle supporting the overall stronger effects of this treatment in skeletal muscles.
    Type of Medium: Online Resource
    ISSN: 2190-5991 , 2190-6009
    URL: Issue
    URL: Article
    DOI: 10.1002/jcsm.v9.2
    DOI: 10.1002/jcsm.12265
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2586864-0
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  • 9
    Online Resource
    Online Resource
    Did the risk of exposure to online hate increase after the November 2015 Paris attacks? A group relations approach
    Elsevier BV ; 2018
    In:  Computers in Human Behavior Vol. 78 ( 2018-01), p. 90-97
    Details
    In: Computers in Human Behavior, Elsevier BV, Vol. 78 ( 2018-01), p. 90-97
    Type of Medium: Online Resource
    ISSN: 0747-5632
    URL: Article
    DOI: 10.1016/j.chb.2017.09.022
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2001911-7
    SSG: 5,2
    SSG: 7,11
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  • 10
    Online Resource
    Online Resource
    Do routine activities help predict young adults’ online harassment: A multi-nation study
    SAGE Publications ; 2017
    In:  Criminology & Criminal Justice Vol. 17, No. 4 ( 2017-09), p. 418-432
    Details
    In: Criminology & Criminal Justice, SAGE Publications, Vol. 17, No. 4 ( 2017-09), p. 418-432
    Abstract: This study examined the feasibility of routine activity theory in predicting online harassment victimization of people aged 15 to 30 years in the USA, Finland, Germany, and the UK. Logistic regression models controlled for socio-demographic factors, exposure to offender, target suitability, and absence of guardianship. According to the results, between 15 percent and 20 percent of respondents reported having been victims of online harassment. Of routine activity theory variables tested, only exposure to offenders was statistically significant in each of the four countries. Females were more likely to be victims than males in Finland, but not in other countries. Those with an immigrant background had a higher likelihood of being victims in Germany, but not in the other countries, whereas the protective role of guardianship was supported in the USA and Germany. Our findings indicate that while routine activity theory is a useful tool for predicting online victimization, its feasibility varied across countries.
    Type of Medium: Online Resource
    ISSN: 1748-8958 , 1748-8966
    URL: Article
    DOI: 10.1177/1748895816679866
    RVK:
    PH 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2063005-0
    SSG: 2
    SSG: 2,1
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